Evaluation of Antimicrobial Activity of Conyza bonariensis Leaf Extracts against Clinically Isolated Fungi Causing Superficial Infection

Girma, Yidnekachew; Jiru, Tamene Milkessa

doi:10.1155/2021/6367449

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…42 Study of antimicrobial activities of leaves crude extracts from various plants, such as Cichorium endivia leaves from Egypt using methanol. 46 C. bonariensis leaves from Arusha Tanzania using ethyl acetate. 15 Crude extracts from five medicinal plants found in Saudi Arabia using ethanol extract.…”

Section: Discussionmentioning

confidence: 99%

Chemical profiling and antimicrobial potential of crude extract and essential oil from Conyza bonariensis leaves

Mpenda,

Nsindagi,

Mpinda

2024

Baghdad J. Biochem. Appl. Biol. Sci.

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Background and objectives: Microbial infections have made significant contributions to the global health burden, particularly in developing countries with lagging economies. Challenges arising from the evolution of antimicrobial resistant (AMR) bacteria have led to the search for novel antimicrobial agents, especially those derived from medicinal plants. Therefore, this study aimed to assess the antibacterial activity of ethyl acetate crude extracts and essential oils from C. bonariensis collected from the Mbeya region of Tanzania. Methods: Initial experimental activities involved preparation of crude extracts and essential oil, which were then, tested for antimicrobial activity against selected test organisms (Staphlococcus aureus (ATCC29213), Bacillus subtilis (ATCC6051), Escherichia coli (ATCC8736), Salmonella typhi (ATCC6539), and Candida albicans (DSM1665)) by using the disc diffusion method. On the other hand, the chemical composition profiling of ethyl acetate and essential oils was performed by gas chromatography mass spectrometry (GC-MS). Results: The crude extracts and essential oil of C. bonariensis leaves from Tanzania demonstrated to have antibacterial and antifungal activity. The minimum inhibition concentration (MIC) of leaves ethyl acetate crude extract was 25 mg/mL > MIC > 12.5 mg/mL for tested organisms, with the exception of C. albicans, where the MIC was 50 mg/mL > MIC > 25 mg/mL. Similary, for all tested organisms, the MIC of leaves essential oils was :1 > MIC > l:2, except S. typhi, where the MIC was 2:1 > MIC > 1:1. On the other hand, 2,4-di-tert-butyl phenol in leaves crude extracts had the highest percentage composition of peak area (41%); whereas, in essential of, 2,4-Di-tert-butyl phenol had the highest percentage composition (38.8%). Conclusions: The present findings have demonstrated antimicrobial potential of ethyl acetate crude extract and essential oil of C. bonariensis leaves from Tanzania, and validate the wide use of the plant by local communities, particularly the local community of Mbeya region in Tanzania.

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Section: Discussionmentioning

confidence: 99%

Chemical profiling and antimicrobial potential of crude extract and essential oil from Conyza bonariensis leaves

Mpenda,

Nsindagi,

Mpinda

2024

Baghdad J. Biochem. Appl. Biol. Sci.

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“…The MIC is the lowest concentration where no viability was observed after 24 h on the basis of metabolic activity. MIC value of each crude plant extract was estimated using broth microdilution method [ 15 , 16 ]. 100 μ L of sabouraud dextrose broth was added to wells of a microtiter plate for each pathogenic fungal strain.…”

Section: Methodsmentioning

confidence: 99%

Antifungal Activity of Plantago lanceolata and Sida ovata Leaf Extracts against Dermatomycotic Fungi

Jiru

Getahun

2023

Evidence-Based Complementary and Alternative Medicine

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Plantago lanceolata and Sida ovata have been used as medicinal plants for centuries to cure numerous diseases. This study aimed to evaluate antifungal activity of P. lanceolata and S. ovata leaf extracts against dermatomycotic fungi. Crude extracts from leaves of both plants were prepared using methanol and ethyl acetate. Phytochemical screening of both plants leaves was performed. Antifungal activity of crude extracts was evaluated against three dermatomycotic fungi (Candida albicans, Malassezia furfur, and Malassezia globosa). In addition, minimum inhibitory concentration (MIC) of the extracts was determined by microbroth dilution method. Maximum inhibition zone of 32.00 ± 11.64 mm was exhibited when combined ethyl acetate extract of both plants was applied against M. globosa. Best effect of MIC was demonstrated by ethyl acetate extract against most tested dermatomycotic fungi. Average MIC of ethyl acetate and methanol extracts ranged as follows: (0.19 ± 0.00 to 0.65 ± 0.00 mg/mL and 0.19 ± 0.00 to 0.52 ± 0.22 mg/mL) and (0.65 ± 0.22 to 1.56 ± 0.00 mg/mL and 0.19 ± 0.00 to 0.52 ± 0.00 mg/mL), respectively. Their synergistic effect was better than the effect of individual plant leaf extract. Minimum fungicidal concentration (MFC) values varied across the fungal pathogens when extracts from both plants and their combinations were used. The findings from the current study support the traditional use of P. lanceolata and S. ovata against dermatomycotic fungal infections, which could potentially be exploited for the treatment of superficial infection in humans.

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“…The assay was repeated twice for each shampoo for four different concentrations-5%, 10%, 20% and 40%. Ketoconazole (Ketocip) shampoo was used as positive control and Control shampoo was used as negative control (Kulkarni et al 2020;Dhanablan et al 2022;Girma et al 2021;Vijayakumar et al 2006;Massiha et al 2015).…”

Section: Antifungal Activity Of Herbal Shampoosmentioning

confidence: 99%

Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis

Chattar,

Pimple,

Kuchekar

et al. 2024

MBJ

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Cosmetics have been used by humans since centuries for variety of purposes, including enhancing appearance, protection and cleansing. Herbal ingredients have been used in cosmetics for their natural and beneficial properties. When combined, herbal ingredients and cosmetics can provide a number of benefits, including improved skin health, protection from the sun and a more youthful appearance. Shampoo is a key part of hair cosmetics which is used to clean scalp and hair. There are many scalp infections such as Seborrheic Dermatitis, Scalp Psoriasis and Candidiasis which are caused by the fungus Candida albicans and are treated by using antifungal shampoos. But it was observed that marketed antifungal shampoos cause various side effects such as alopecia, eye irritation, dry hair, abnormal hair texture, dry scalp and headache etc. The current study focuses on comparison of antifungal potential of six herbal shampoos developed using isolated phytoconstituents such as Rutin, Eugenol, Camphor and Menthol; as well as their combination. The results showed that antifungal potential of all the six developed herbal shampoos against Candida albicans causing Seborrheic dermatitis is comparable to the marketed synthetic antifungal shampoo. Hence, it is concluded that the six developed shampoos can be successfully used to treat Seborrheic dermatitis caused by Candida albicans.

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Evaluation of Antimicrobial Activity of Conyza bonariensis Leaf Extracts against Clinically Isolated Fungi Causing Superficial Infection

Cited by 3 publications

References 39 publications

Chemical profiling and antimicrobial potential of crude extract and essential oil from Conyza bonariensis leaves

Chemical profiling and antimicrobial potential of crude extract and essential oil from Conyza bonariensis leaves

Antifungal Activity of Plantago lanceolata and Sida ovata Leaf Extracts against Dermatomycotic Fungi

Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis

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