Evaluation of antilymphocyteserum: comparison of skinallograft survival and rosette inhibition

Kissling, M.; Speck, B

doi:10.1007/bf01913281

Cited by 1 publication

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“…ALS was produced in a horse by repeated injections with rabbit thoracic duct lymphocytes. The efficacy of this serum was clearly established by prolongation of skin allograft survival and by in vitro inhibition of rosette formation [7]. Condition ing with ALS was started as soon as the peripheral white blood cell count had dropped below 1,500/mm3.…”

Section: Methodsmentioning

confidence: 99%

Studies on Bone Marrow Transplantation in Experimental <sup>32</sup>P-Induced Aplastic Anemia after Conditioning with Antilymphocyte Serum

Speck¹,

Kissling²

1973

Acta Haematol

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Aplastic anemia was produced with ³²P in rabbits with and without splenectomy. Transient hemopoietic engraftment without graft versus host (GvH) was seen after conditioning with antilymphocyte serum (ALS) and infusion of allogeneic marrow from a strain that is known to cause fatal secondary disease if total body irradiation is used for conditioning. More takes could be achieved in the splenectomized group but in both groups the takes were only transient. The absence of GvH was shown to be probably due to a split chimerism of the immunologic system. The graft rejections are felt to be due to the persistence of host T cells. Possibly the duration of engraftment can be prolonged in the future by continued immunosuppressive therapy after transplantation with ALS or cyclophosphamide. The fact that the spleen is not necessary for hemopoietic recovery after i.v. marrow infusion may have important clinical implications because many patients with aplastic anemia are splenectomized in the course of their disease

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Section: Methodsmentioning

confidence: 99%