Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus <i>Paecilomyces</i> sp

Braun, Glaucia Hollaender; Ramos, Henrique Pereira; Cândido, Ana Carolina Bolela Bovo; Pedroso, Rita Cássia Nascimento; Siqueira, Kátia Aparecida de; Soares, Marcos Antônio; Dias, Gustavo Muniz; Magalhães, Lizandra G.; Ambrósio, Sérgio Ricardo; Januário, Ana Helena; Pietro, Rosemeire Cristina Linhari Rodrigues

doi:10.1080/14786419.2019.1619725

Cited by 23 publications

(7 citation statements)

References 13 publications

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“…5e), isolated from a fungus, Paecilomyces sp. 7A22 showed potent activity against promastigotes forms (IC 50 = 5.25 µg/ml) and intracellular amastigotes (IC 50 = 18.18 µg/ml) of L. amazonensis, though, less potent than reference antibiotic, amphotericin B (0.119 and 0.095 µg/ml) [48].…”

Section: Marine-derived Quinones Macrolide Lactones and Sterolmentioning

confidence: 95%

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

et al. 2021

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Background Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa, Asia, and the Americas. Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period, which have encouraged resistance. These have prompted many researchers to focus on finding new drugs that are safe, effective, and affordable from marine environments. The aim of this review was to show the diversity, structural scaffolds, in-vitro or in-vivo efficacy, and recent progress made in the discovery/isolation of marine natural products (MNPs) with potent bioactivity against malaria, leishmaniasis, and trypanosomiasis. Main text We searched PubMed and Google scholar using Boolean Operators (AND, OR, and NOT) and the combination of related terms for articles on marine natural products (MNPs) discovery published only in English language from January 2016 to June 2020. Twenty nine articles reported the isolation, identification and antiparasitic activity of the isolated compounds from marine environment. A total of 125 compounds were reported to have been isolated, out of which 45 were newly isolated compounds. These compounds were all isolated from bacteria, a fungus, sponges, algae, a bryozoan, cnidarians and soft corals. In recent years, great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds. Comparably, some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs. However, very few of these MNPs have a pharmaceutical destiny due to lack of the following: sustainable production of the bioactive compounds, standard efficient screening methods, knowledge of the mechanism of action, partnerships between researchers and pharmaceutical industries. Conclusions It is crystal clear that marine organisms are a rich source of antiparasitic compounds, such as alkaloids, terpenoids, peptides, polyketides, terpene, coumarins, steroids, fatty acid derivatives, and lactones. The current and future technological innovation in natural products drug discovery will bolster the drug armamentarium for malaria and neglected tropical diseases.

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Section: Marine-derived Quinones Macrolide Lactones and Sterolmentioning

confidence: 95%

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

et al. 2021

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“…But its antileishmanial activities were only moderate against L. amazonensis promastigotes (IC 50 = 5.25 μg/ mL, 27.3 μM) or weak against L. amazonensis amastigotes (IC 50 = 18.18 μg/mL, 94.6 μM). [55] Table 2 and Figure 2 summarize the outcome of the studies with algae and fungal sources for the identification of antileishmanial constituents.…”

Section: Natural Anti-leishmanial Extracts Oils and Isolates From Plants Algae And Fungimentioning

confidence: 99%

An Update on Natural Antileishmanial Treatment Options from Plants, Fungi and Algae

Koko

Nasr

Khan

et al. 2021

Chemistry & Biodiversity

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Efficient drugs for the treatment of leishmaniasis, which is classified as a neglected tropical disease, are sought for. This review covers potential drug candidates from natural plant, fungus and algae sources, which were described over the last six years. The identification of these natural antileishmanials often based on the knowledge of traditional medicines. Crucial insights into the activities of these natural remedies against Leishmania parasites and against infections caused by these parasites in laboratory animals or patients are provided and compared with selected former active examples published more than six years ago. In addition, immuno-modulatory natural antileishmanials and recent developments on combination therapies including natural products and approved antileishmanials are discussed. The described natural products revealed promising data warranting further efforts on the discovery and development of new antileishmanials based on patterns from nature.

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“… Polyketide Coibacin A –D 0.68–4.99 μg mL −1 [ 87 ] Marine Algae Bifurcaria bifurcate (Brown alga) Terpene Bifurcatriol L. donovani amastigotes (18.8 μg/ml) [ 88 ] Dictyota spirali Terpene Spiralyde A L. amazonensis promastigotes (15.47 ± 0.26 and 36.81 ± 5.20 μmol/L) [ 89 ] Cystoseira baccata Terpene tetraprenyltoluquinol and tetraprenyl L. infantum promastigotes and amastigotes (44.9 ± 4.3 and 94.4 ± 10.1 μmol/L) [ 90 ] Stypopodium zonale Terpene Atomaric acid and its methyl ester derivative L. amazonensis intracellular amastigotes (20.2 and 22.9 μmol/L) [ 91 ] Laurencia viridis (red algae) Terpene Oxasqualenoid metabolites Promastigotes of L. Amazonensis and L. donovani (5.40–46.45 μmol/L) [ 92 ] Marine Fungi Eurotium repens Polyketide Tetrahydroauroglaucin 22 μg mL −1 [ 93 ] Flavoglaucin 23 μg mL −1 Auroglaucin 7.5 μg mL −1 Paecilomyces sp. 7A22 Lactone Harzialactone A L. amazonensis promastigotes forms (5.25 μg/ml) and intracellular amastigotes (18.18 μg/ml) [ 77 , 94 ] Marine seaweed …”

Section: Marine Actinomycetes As Sources For Antileishmanial Drugsmentioning

confidence: 99%

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

Davies-Bolorunduro

Osuolale

Saibu

et al. 2021

Heliyon

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp

Cited by 23 publications

References 13 publications

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

An Update on Natural Antileishmanial Treatment Options from Plants, Fungi and Algae

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

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