Evaluation of Antihypertensive and Antihyperlipidemic Effects of Bamboo Shoot Angiotensin Converting Enzyme Inhibitory Peptide in Vivo

Abstract

Cardiovascular protective functions of bamboo shoot angiotensin converting enzyme (ACE) inhibitory peptide (BSP) from bamboo shoot were evaluated, including antihypertensive effect on spontaneously hypertensive rats (SHRs) and antihyperlipidemic effect on high-fat-diet-induced rats. Thirty-day antihypertensive effects of BSP on SHRs were assayed. Asp-Tyr [10 mg/day kg body weight (BW)] and BSP (50 mg/day kg BW) significantly reduced ACE activity in lung at the same level (p < 0.05), while BSP (50 mg/day kg BW) reduced systolic blood pressure (SBP) more effectively for its phenolic compounds, such as ferulic acid and p-coumaric acid, which when combined with ACE inhibitor exert a synergistic effect. BSP could significantly reduce SBP, improve oxidant stress status (GSH-Px, SOD, TAC and MDA), and increase NO level in serum and NOS activity in kidney. BSP decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) content and MDA level of hyperlipidemic rats, which might contribute to the ACE inhibitory capacity of Asp-Tyr and the fatty acid synthase inhibitory activity of phenolic compounds.

Two new compounds from the dry leaves of Pleioblastus amarus (Keng) keng f.

“…At present, studies of the chemical constituents of bamboo revealed the occurrence of molecules such as flavonoids, lignans, and polyphenols [3 -6]. In our recent phytochemical investigations, two new compounds, xylitol 1-O-(6 0 -O-p-hydroxylbenzoyl)-glucopyranoside (1) and bambulignan B (2) (Figure 1), together with three known ones (3)(4)(5), were obtained from this plant. Compound 1 bears a rare xylitol group, and compound 2 is a new member of bamboo lignans ( Figure 1).…”

Isolation and identification of bound compounds from corn bran and their antioxidant and angiotensin I-converting enzyme inhibitory activities

“…To overcome these limitations, an increasing number of interest has been paid to find new ACE inhibitors that are capable of providing similar therapeutic effects, but with greater safety margins. Edible plants targeting ACE inhibition, such as peptides, flavonoids, and triterpenes, have been reported in the literature [39][40][41].…”

Effects of Bambusae Caulis in Taeniam Extract on the UVB-induced Cell Death, Oxidative Stress and Matrix Metalloproteinase 1 Expression in Keratinocytes

“…1B. Because p-CA has been reported as a major phenolic compound contained in many bamboo species such as Phyllostachys pubescens (Pradelle) Mazel ex J. Houz [30] and Sasa quelpaertensis Nakai [31], we analyzed the content of p-CA in BCTE using HPLC and it was determined to be 1.7%. ) in the absence and presence of BCTE (10, 30, or 100 µg/mL) or p-CA (10 µg/mL), followed by incubation for 24 h. The whole cell lysates were subjected to western blot analysis for procaspase 3 and its cleaved form (A), and Bax and Bcl-2(B).…”

“…4). Like the cases of other bamboo species [30,31], p-CA was assumed to contribute to bioactivities of BCTE. The protective effects of p-CA against the UV-induced inflammatory responses or injury has been previously observed in cells and in vivo models [32][33][34].…”