Evaluation of antigenotoxic effects of juices of plants Chelidonium majus L., Plantago major L. и Tussilago farfara L.

Fatykhova, D. G.; Karamova, Nazira S.; Abdrahimova, Yoldyz R; Ilinskaya, О. N.

doi:10.17816/ecogen8256-65

Cited by 5 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lee et al [149] reported the (TF)-induced cytotoxic and apoptotic activities of the flower part of T. farfara in human colon cancer cell line (HT-29) by using a methanolic extract. Fatykhova et al [150] showed the genotoxic activity of T. farfara herb juice against known genotoxic compounds like nalidixic acid in SOS chromotest and furacilin in Rec assay. Their findings showed that dilution of the herb juice gave maximum antimutagenic properties in SOS chromotest as compared to furacilin in Rec assay.…”

Section: Tussilago Farfaramentioning

confidence: 99%

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Khan

Ali

Khan³

et al. 2019

Biomolecules

239

118

View full text Add to dashboard Cite

The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.

show abstract

Section: Tussilago Farfaramentioning

confidence: 99%

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Khan

Ali

Khan³

et al. 2019

Biomolecules

239

118

View full text Add to dashboard Cite

show abstract

“…farfara in mortal colon cancer cell line( HT-29) by using a methanolic excerpt. Fatykhova et al 114 showed the genotoxic exertion of T. farfara condiment juice against known genotoxic composites like nalidixic acid in SOS chromotest and furacilin in Rec assay. Their findings showed that dilution of the condiment juice gave maximum antimutagenic porperty in SOS chromotest as compared to furacilin in Rec assay.…”

Section: Scutellaria Baicalensismentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt of applicable keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty shops were named grounded on defined selection criteria for their potent anticancer composites. The detailed analysis of the exploration studies revealed that plants play a necessary part in fighting different cancers similar as bone, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in-vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-converting enzymes by the secondary metabolites in the plant excerpts. Studies that reported in-vivo conditioning of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring further plants, their active composites, and the medium of anticancer conduct for use as standard herbal drug. INTRODUCTION:The burden of cancer rose to 18.1 million new cases and 9.6 million deaths in 2018. With 36 different types, cancer mainly affects men in the form of colorectal, liver, lung, prostate, and stomach cancer and women in the form of breast, cervix, colorectal, lung, and thyroid cancer 1 . Treating cancer has come a whole new area of exploration. There are conventional as well as truly modern ways applied against cancers. A variety of ways i.e., chemotherapy, radiation remedy, or surgery are used for treating cancer. Still, all of them have some disadvantages 2 . The use of conventional chemicals bears side goods and venom 3 .

show abstract

“…В настоящее время изучаются соки из сырья алоэ древовидного, каланхоэ перистого, крапивы двудомной, подорожника большого, мать-и-мачехи обыкновенной, чистотела большого, побегов каллизии душистой и др. [15][16][17][18]. Перспективность разработки лекарственных средств на основе сока из травы манжетки обыкновенной продиктована выявленной у него психомоторной активностью [19].…”

Section: Introductionunclassified

Aspects of Standardization in the Juice of the Herbs <i>Alchemilla vulgaris</i>

Cheremnykh

Zorina

V.D.

2022

Razrabotka i registraciâ lekarstvennyh sredstv

View full text Add to dashboard Cite

Introduction. The features of the chemical composition and the identified pharmacological activities of substances from fresh raw materials of the Alchemilla vulgaris allow us to predict the prospects for the use of juice from the herb Alchemilla vulgaris in medical practice. The creation of drugs based on juices from fresh herb Alchemilla involves the development of methods for their standardization.Aim. To determine the methods of qualitative analysis for the identification and quantitative assessment of the main group of biologically active substances in Alchemilla vulgaris juice.Materials and methods. The herb Alchemilla vulgaris for juice production was harvested during the flowering period in various habitats. The qualitative composition of the phenolic compounds of the juice was studied by paper chromatography and thin layer chromatography (TLC). The quantitative determination procedure was developed and validated on an SF-2000 spectrophotometer.Results and discussion. Paper chromatography (CP) in the juice revealed derivatives of cinnamic and phenolcarboxylic acids, a group of flavonoids with a predominance of flavones and flavonols, rutin was identified among the dominant ones. The TLC in the butanol : acetic acid : water system (4 : 1 : 2), we achieved optimal separation of substances and identified rutin, which was proposed as the main substance in juice standardization. Correspondence of the configuration of the differential spectrum of the complex of cuff juice flavonoids with aluminum chloride to the spectrum of a similar complex of rutin SS and the results of TLC give grounds to use rutin as a standard. The best option when choosing an aliquot for quantitative determination of reliable results showed the use of 0.2 ml of juice. The content of flavonoids in the studied juice samples ranged from 2.15 ± 0.24 % to 7.34 ± 0.16 %.Conclusion. TLC in the butanol-acetic acid-water system (4 : 1 : 2) can be used to authenticate the juice from the herb Alchemilla vulgaris. The parameters of the method of quantitative determination are developed taking into account the variation in the ratio of the water component and the dry residue in the juice. The method is valid and can be used to standardize juice from the herb Alchemilla vulgaris. The taxation of Alchemilla vulgaris juice samples showed the variability of the content of flavonoids in the juice depending on the growing conditions.

show abstract

Evaluation of antigenotoxic effects of juices of plants Chelidonium majus L., Plantago major L. и Tussilago farfara L.

Cited by 5 publications

References 30 publications

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Untitled

Aspects of Standardization in the Juice of the Herbs <i>Alchemilla vulgaris</i>

Contact Info

Product

Resources

About