Evaluation of Antiepileptic Activity of Methanolic Extract of Opuntia Ficus Indica Flower in Mice

Kumar, Kalbant

doi:10.20959/wjpr20178-7853

Cited by 2 publications

(2 citation statements)

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“…It also offered up to 62.5% protection against seizure at 200 mg/kg which was significant (p < 0.05) as compared to diazepam [ 159 ] 16 Nicotiana tabacum Ar AQ & HME PTZ Random breed albino male mice (18–24 g) 100 Both extracts decreased the onset and severity of seizures (but it is statistically insignificant as compared to the negative control group). Both extracts decreased the mortality of PTZ-treated mice [ 160 ] 17 Olea europaea – – PTZ Mice weighing (25–30 g) 20 The active constituent of Olea europaea leaf, oleuropein (20 mg/kg), caused a significant increase in seizure latency and a significant decrease in the whole body seizure [ 161 ] 18 Opuntia ficus-indica Fl HME PTZ, MES & STR Swiss albino mice (20–25 g) 250 & 500 Protect the mice against PTZ, MES, and STR-induced seizures [ 135 ] 19 Pentas schimperiana RB HME PTZ & MES Swiss albino mice (20–30 g) 100–400 The BU and ME fractions significantly inhibited the PTZ and MES-induced seizure at 400 mg/kg [ 162 ] 20 Pterolobium stellatum L AQ & HME PTZ & MES Swiss albino mice (25–32 g) 100–400 The HME extract exhibited a dose-dependent increase on the latency onset of seizure against PTZ. In addition, both HME and AQ fractions demonstrat...…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

“…Overall, the result suggested that Croton macrostachyus may have a promising effect in secondary GTCS and primary generalized seizures in humans. Opuntia ficus-indica commonly known as cactus pear is used in the treatment of epilepsy in Ethiopia and India [ 135 ]. The in vivo anticonvulsant activity of the flower ME extract was assessed using Swiss Albino mice.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

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Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for the symptomatic relief of epilepsy. The incidence of refractory epilepsy and the dose-dependent neurotoxicity of AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, and other side effects are the major bottlenecks in epilepsy treatment. In low- and middle-income countries (LMICs), epilepsy patients failed to adhere to the AEDs regimens and consider other options such as complementary and alternative medicines (CAMs) to relieve pain due to status epilepticus (SE). Plant-based CAMs are widely employed for the treatment of epilepsy across the globe including Ethiopia. The current review documented around 96 plant species (PS) that are often used for the treatment of epilepsy in Ethiopia. It also described the in vivo anticonvulsant activities and toxicity profiles of the antiepileptic medicinal plants (MPs). Moreover, the phytochemical constituents of MPs with profound anticonvulsant effects were also assessed. The result reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

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Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which is one of the major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for the management of epilepsy. More than 30 drugs have been approved by the US FDA against epilepsy. However, one-quarter of epileptic individuals still show resistance to the current medications. About 90% of individuals in low and middle-income countries do not have access to the current medication. In these countries, plant extracts have been used to treat various diseases, including epilepsy. These medicinal plants have high therapeutic value and contain valuable phytochemicals with diverse biomedical applications. Epilepsy is a multifactorial disease, and therefore, multitarget approaches such as plant extracts or extracted phytochemicals are needed, which can target multiple pathways. Numerous plant extracts and phytochemicals have been shown to treat epilepsy in various animal models by targeting various receptors, enzymes, and metabolic pathways. These extracts and phytochemicals could be used for the treatment of epilepsy in humans in the future; however, further research is needed to study the exact mechanism of action, toxicity, and dosage to reduce their side effects. In this narrative review, we comprehensively summarized the extracts of various plant species and purified phytochemicals isolated from plants, their targets and mechanism of action, and dosage used in various animal models against epilepsy.

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Evaluation of Antiepileptic Activity of Methanolic Extract of Opuntia Ficus Indica Flower in Mice

Abstract: Opuntia ficus indica flowers (L) commonly known as cactus pear

Cited by 2 publications

References 5 publications

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

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