Evaluation of Antiepileptic Activity of Methanolic Leaves Extract of &lt;i&gt;Tragia involucrata&lt;/i&gt; Linn. in Mice

Varma, Ganapathi G.; Mathai, Benson K.; Kuntal, Das; Gowda, Girish; Rammohan, S.; Einstein, John Wilking

doi:10.18052/www.scipress.com/ilns.17.167

Cited by 5 publications

(4 citation statements)

References 22 publications

(18 reference statements)

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“…Important bioactives such as alkaloids, flavonoids, phenolic compounds and tannins and glycosides were found to be present in the root extracts. The protective role of these bioactive types [36][37][38] in PTZ-induced convulsions is described earlier; for instance, there are reports on flavonoids binding to GABA A receptor causing anticonvulsant effects [39]. Additionally, flavonoids also possess antioxidant property and can protect brain from oxidative damage [39].…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostical evaluation and anti-convulsant property of Annona reticulata Linn. (Annonaceae) root

2021

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Background The present investigation was aimed at establishing the pharmacognostical parameters and preliminary phytochemical screening of Annona reticulata Linn. (Annonaceae) root. Pharmacognostical studies and phytochemical evaluation of A. reticulata root were carried out by following standard procedures to provide information that help to identify the species. The species of Annonaceae family are documented to possess anticonvulsant property, while A. reticulata and its root are reported to be used as a folklore medicine to treat epilepsy. In this study, anti-convulsant activity of the root extract was further investigated in mouse model with seizures induced by pentylenetetrazole (PTZ; 60 mg/kg, i.p.). Diazepam (5 mg/kg) was used as a standard anti-convulsant drug. Prior to induction of seizures, ethanol extract (100, 200, and 400 mg/kg, p.o.,) and 0.1% sodium CMC were administered. Later, the onset, duration of convulsions along with recovery was recorded. Results A. reticulata can be recognized by its crown shape, leaves with lengthy petioles, fleshy petals and heart-shaped fruits. Roots are cylindrical with rootlets and have aromatic odour. Presence of oil globules and rhomboidal calcium oxalate crystals in cortex, sclerenchyma cells in cortex and secondary phloem, starch grains in cortex, secondary phloem and secondary xylem, and uni- to tri-seriate medullary rays are the key diagnostic characters of root. Preliminary phytochemical screening of extracts revealed the presence of phenolic compounds, tannins, alkaloids, carbohydrates, flavonoids, glycosides, saponins, proteins, fixed oil and fats. The total alkaloid content in the root was 0.524% w/w, while total flavonoid and total phenolic content in ethanol extract were 16.65 mg QE/g and 59.54 mg GAE/g, respectively. Based on the values obtained from anti-convulsant activity, it is evident that the ethanol extract offered significant protection against PTZ-induced convulsion in mice. Conclusion The current pharmacognostical study aids not only in identification of crude drug material but also in establishing the standardization parameters. Further, the findings of this study indicated that the ethanolic extract of Annona reticulata Linn root displayed significant anti-convulsant property and this property could be attributed to imperative bioactives like flavonoids, phenolic compounds, alkaloids, in addition to other secondary metabolites.

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Section: Discussionmentioning

confidence: 99%

Pharmacognostical evaluation and anti-convulsant property of Annona reticulata Linn. (Annonaceae) root

2021

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“…Yadav et al [ 61 ] shows antihistamine activity of 5-hydroxy-1-methylpiperidin-2-one (5-HMP) isolated from the TI leaf extract, which further found to be mediated through the formation of protein-ligand complex by binding to human serum albumin [ 61 ]. Also, a few in vivo studies have been performed to check antifertility activity [ 51 ], antiepileptic activity [ 101 , 102 ], antihistamine activity [ 60 ], hepatoprotective activity [ 103 ], and nephroprotective activity [ 104 ] using different extracts of different parts of TI plant. All these activities showed positive results for the used extract and for the given dose.…”

Section: Biological Activities and Phytochemicals Found In mentioning

confidence: 99%

“…Acute toxicity performed using the aqueous extract of whole plant of TI for fourteen days showed negative results at a dose of 5000 mg/kg on healthy male Wistar rats [ 105 ]. The methanolic extract of whole plant and leaf did not show 14 days oral acute toxicity at a dose of 2000 mg/kg/day on healthy Wistar rats and Swiss albino mice [ 12 , 101 ]. The ethyl acetate extract of the aerial part of TI was given to healthy Swiss albino mice through intraperitoneal administration [ 51 ] using different doses.…”

Section: Toxicities Associated With Tragia Involucrata mentioning

confidence: 99%

Ethnopharmacological Use and Biological Activities of Tragia involucrata L.

Pallie

Perera

Kumarasinghe

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Plants have been utilized as medicines to treat various ailments since ancient times. Formulations made by plant materials have been used in traditional, complementary, and alternative medicine and remain widespread in both developing and developed countries. In developing countries, traditional medicines are widely practiced due to its accessibility and affordability, while in developed countries, complementary and alternative medicine are widely popular due to the adverse effects of chemical drugs. Tragia involucrata Linn. (family: Euphorbiaceae) is a highly used medicinal plant used in both Sri Lankan and Indian traditional medical systems. Since this plant is a weed, it is being extensively destroyed due to the lack of knowledge regarding the medicinal value of this plant. Hence, the objective of this study was to collect data on the medicinal value of this plant by correlating its scientifically validated biological activities with its ethnopharmacological uses. An attempt was made to gather as much information available regarding the ethnopharmacological uses and scientifically validated biological activities of Tragia involucrata through authentic traditional texts, scientific journals, and other authentic texts regarding medicinal plants. Thus, the review provides an insight to the capability of Tragia involucrata to be used as a monoherbal formulation for diseases pertaining to multiple systems of the body. With all the scientifically validated biological activities and the ethnopharmacological uses, Tragia involucrata may qualify as a potent candidate to be developed into a phytomedicine to be utilized as both a preventive and as a therapeutic agent.

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“…It also showed significant decrease in brain MDA level in lipid peroxidation profile, and increase in the brain glutathione levels in mice against Pentylenetetrazole induced convulsion. The Tragia involucrate possesses dose dependent antiepileptic activity 16,18 .…”

Section: Antiepileptic Activitymentioning

confidence: 99%

Phytochemical, PharmacologicalProfiles of Tragia involucrata

2018

IJCTR

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Tragia involucrata is a slender, twining her with stinging hairs. The various activities were assessed by anti-inflammatory activity with carrageenan induced rat paw oedema, diuretic activity by Lipschitz model and anthelmintic activity by earthworm model, analgesic activity by radiant heat induced nociception. The Preliminary phytochemical investigation revealed the presence of tannins and flavanoids in petroleum ether extract of Tragia involucrata, alkaloids in chloroform extract of Tragia involucrata and saponins in aqueous extract of Tragia involucrata. All the three extracts exhibited anti-inflammatory, analgesic, diuretic and anthelmintic activities. This review provides a basis for future investigation of Tragia involucrata species and especially for those species that have not been explored for phytochemical and pharmacological activities.

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Evaluation of Antiepileptic Activity of Methanolic Leaves Extract of <i>Tragia involucrata</i> Linn. in Mice

Cited by 5 publications

References 22 publications

Pharmacognostical evaluation and anti-convulsant property of Annona reticulata Linn. (Annonaceae) root

Pharmacognostical evaluation and anti-convulsant property of Annona reticulata Linn. (Annonaceae) root

Ethnopharmacological Use and Biological Activities of Tragia involucrata L.

Phytochemical, PharmacologicalProfiles of Tragia involucrata

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