Evaluation of Antidiarrheal Activity of Bryophyllum Pinnatum Lam. (Oken) Leaves Extracts and Isolation of Active Constituent.

Abstract

Bryophyllum pinnatum Lam. (Oken) (Crassulaceae) are commonly known as miracle plant. Traditionally, this plant is used to heal wounds and to treat diarrhoea. For this reason, the main aim of the present study is to evaluate the antidiarrheal activity using castor oil-induced diarrhea model. Loperamide drug (3 mg dose, p.o.) was used as standard drug. The EAE and EE at 200mg dose and 400 mg dose, p.o. respectively produced dose-dependent protection of mice with significant P value (P < 0.001). Both extracts of plant produced dose-dependent and significant P-value (P < 0.001) towards antimotility effect compared with negative control (castor oil) group in model. EE (400 mg dose p.o.) possess better antidiarrheal potential in mice groups due to presence of flavone. 5-methyl-4,5,7- trihydroxy flavone was isolated from the ethanol extract. Finally, it can be concluded that, Bryophyllum pinnatum Lam. (Oken) leaves can be used ethnomedicinally to treat, counterbalance, bulwark, and control diarrhea.

Phytochemical Studies Of Bryophyllum Pinnatum Lam. (Oken) Leaves Extracts And Evaluation Of Its Wound Healing Activity

“…Methanol, being a polar dissolvable, can proficiently remove a different exhibit of phytochemicals, in this manner expanding the restorative capability of the concentrate. Also, the presence of polar mixtures, for example, glycosides and saponins in the methanol concentrate might add to its injury recuperating movement by advancing cell multiplication, angiogenesis, and tissue recovery (Yadav et al, 2022).…”