Evaluation of antidiabetic effect of total calystegines extracted from Hyoscyamus albus

Bourebaba, Lynda; Saci, Souaad; Touguit, Damia; Gali, Lynda; Terkmane, S.; Oukil, Naima; Bedjou, Fatiha

doi:10.1016/j.biopha.2016.05.011

Cited by 23 publications

(18 citation statements)

References 25 publications

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“…The study from Bourebaba et al. () suggests that calystegines are not acutely toxic in mice. In this study, no mortality was observed upon a single oral administration of an extract of Hyoscyamus albus containing seven calystegines up to 2,000 mg total calystegines/kg bw.…”

Section: Discussionmentioning

confidence: 99%

“…Bourebaba et al. () studied the possible antidiabetic effects of calystegines in Albino mice. A mixture of calystegines extracted from seeds of Hyoscyamus albus was tested in an acute oral study in female mice.…”

Section: Assessmentmentioning

confidence: 99%

“…At the highest tested dose, castanospermine induced mild vacuolation in the kidney and thyroid, and minimal hepatocyte vacuolation. Bourebaba et al (2016) studied the possible antidiabetic effects of calystegines in Albino mice. A mixture of calystegines extracted from seeds of Hyoscyamus albus was tested in an acute oral study in female mice.…”

Section: 2mentioning

confidence: 99%

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Overview of available toxicity data for calystegines

Binaglia¹,

Baert²,

Schütte³

et al. 2019

EFS2

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Calystegines are polyhydroxylated nortropane alkaloids that have been found in various solanaceous foods, in particular in potatoes and aubergines. The biological activity and potential toxicity of calystegines are associated with their capacity to inhibit glycosidases and block carbohydrate metabolism inducing lysosomal storage toxicity. The present report summarises the retrieved information on the possible toxicity of calystegines. Only few in vivo short‐term toxicological studies in rodents on individual calystegines or mixtures of calystegines were retrieved. Overall, these studies are insufficient to conclude on the possible chronic toxicity effects of calystegines in humans, in particular considering the short duration of the studies and potential lower sensitivity of rats and mice to glycosidase inhibitors, compared to other species such as goats and guinea pigs. Several studies and case reports were retrieved on the toxic effects induced in livestock or experimental animals following consumption or administration of plants containing calystegines. However, the concurrent presence of other alkaloids, in particular swainsonine, did not allow using these studies to draw conclusions on the toxicity of calystegines. Since no experimental data on genotoxicity of calystegines were retrieved, in silico predicting models were applied to identify possible alert for genotoxicity of five calystegines recently detected in food. In most of the cases, the outcome of the computational predictions indicated no alerts for genotoxicity; however, the low reliability of the results prevents a firm conclusion on the genotoxic potential of the substances. Overall, the available data do not allow drawing conclusions on the possible toxic effects of calystegines in humans or in livestock, and more data in relevant experimental models would be necessary to characterise the toxic profile of this group of substances.

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Section: Discussionmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

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Overview of available toxicity data for calystegines

Binaglia¹,

Baert²,

Schütte³

et al. 2019

EFS2

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“…2 Em camundongos diabéticos, esses compostos reduziram para concentrações normais os níveis de glicose no sangue e parâmetros lipídicos, evidenciando que esses compostos sejam potentes agentes antidiabéticos com efeitos anti-hiperglicêmicos. 32…”

Section: Figura 5 Fragmentação De Calisteginas Derivatizadas Eletrounclassified

Calisteginas, Alcalóides Polihidroxilados Presentes Em Hortaliças: Frutos E Tuberosas

Souto

Silva

2019

Quím. Nova

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Calystegines are nortropane alkaloids with three to five hydroxyl groups. These alkaloids are recognized as glycosidase inhibitors and thus may have therapeutic potential to be exploited. There are also reports of its possible toxic effects when they are present in foods. Commercial cultivars of human consumption in Brazil have been analyzed for calystegines content. Samples of Solanum tuberosum L. (potato), Ipomoea batatas L. (sweet potato), Solanum lycopersicum (tomato), Solanum melongena (eggplant) and Solanum aethiopicum L. (gilo) were obtained from local markets in Rio de Janeiro, RJ, Brazil. Qualitative analyzes were performed by gas chromatography coupled to mass spectrometry (GC/MS) and high performance liquid chromatography coupled to mass spectrometry (LC/MS). Gas chromatography with flame ionization detector (GC/FID) was used in quantitative analysis. Five calystegines (A 3 , B 1 , B 2 , B 4 and C 1) were detected in the whole sample set and the amounts of three of them were determined: A 3 (1.94-15.88 mg kg-1); B 2 (7.59-23.7 mg kg-1) and B 4 (3.61-9.38 mg kg-1). This is the first report on the occurrence of these alkaloids in Solanum aethiopicum L.

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“…84 Hyoscyamys albus: Calystegines (A 3 , A 5 , A 5 glycosides, B 1 , B 2 , B 4 , N 1 ) that was isolated from H. albus seeds are potent anti-diabetic agents with antihyperglycemic and hypolipidemic effects, and a protective function on pancreas in streptozotocin induced diabetes. 85 …”

Section: Solanaceaementioning

confidence: 99%

A Review on Anti-diabetic Plants

Qais

Jahan

Shajib

2018

Dhaka Univ. J. Pharm. Sci

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Diabetes mellitus is a common metabolic disorder whose prevalence is rapidly increasing all over the world. According to WHO, diabetes will be the seventh leading cause of death in 2030. Since long back, plants have been used to heal or combat illness and are the source of many modern medicines. In view of the above aspects, the present review provides information about the antidiabetic plants, available through literature source from various database. From the present study it is evident that most of the plants having anti-diabetic properties belong to the family Moraceae, Cucurbitaceae, Liliaceae, Anacardiaceae, Myrtaceae, Fabaceae, Solanaceae, Asteraceae and many others. The hypoglycemic activities are contained in different parts of these plants like leaf, rhizomes, fruits, bark, seeds or other parts which differ from species to species. It is also evident from this review that the mode of action and dosage of administration differs from plant to plant.

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Evaluation of antidiabetic effect of total calystegines extracted from Hyoscyamus albus

Cited by 23 publications

References 25 publications

Overview of available toxicity data for calystegines

Overview of available toxicity data for calystegines

Calisteginas, Alcalóides Polihidroxilados Presentes Em Hortaliças: Frutos E Tuberosas

A Review on Anti-diabetic Plants

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