Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats

Kameswararao, B; Kesavulu, M. M.; Apparao, Ch

doi:10.1016/s0367-326x(02)00297-6

Cited by 113 publications

(48 citation statements)

References 15 publications

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“…Diabetes mellitus is a chronic disease that affects about 5-10% of the world population [4,19]. Diet and weight control are the basic principles in the treatment of type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pistachio Nut Supplementation on Blood Glucose in Patients with Type 2 Diabetes: A Randomized Crossover Trial

et al. 2014

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■ AbstractBACKGROUND: Diabetes is a chronic, potentially debilitating, and often fatal disease. Dietary strategies to reduce postprandial glycemia are important in the prevention and treatment of diabetes. Nuts are rich in mono-and polyunsaturated fatty acids, which may reduce hyperglycemia and improve metabolism. OBJECTIVES: To evaluate the effectiveness of pistachio nut supplementation on glycemic and inflammatory measures in patients with type 2 diabetes. METHODS: In this double-blind, randomized, placebocontrolled, crossover trial, 48 diabetic patients were equally assigned to groups A and B. Patients in group A received a snack of 25 g pistachio nuts twice a day for 12 weeks and group B received a control meal without nuts. After 12 weeks of intervention, the patients had an 8-week washout. Then the groups were displaced, and group B received the same amount of pistachios for 12 weeks. RESULTS: With respect to the total change in variables over both phases, there was a marked decrease in HbA1c (-0.4%) and fasting blood glucose (FBG) concentrations (-16 mg/dl) in the pistachio group compared with the control group (p ≤ 0.001 for both). There was no overall significant change in BMI, blood pressure, HOMA-IR, and C-reactive protein (CRP) concentrations. Analysis of the two phases separately showed a decrease in FBG by 14 mg/dl and in HbA1c by 0.45% in the treatment group (A) after 12 weeks, while no significant differences were seen in group B (control group). In the second phase, FBG decreased from 151.36 ± 39.22 to 137.28 ± 28.65 mg/dl (-14 mg/dl) and HbA1c decreased from 7.42 ± 0.97 to 7.15 ± 0.68 mg/dl (-0.28%, p = 0.013 and p = 0.033, respectively) in the pistachio group (B). Pistachio consumption reduced systolic blood pressure (p = 0.007), BMI (p = 0.011), and CRP (p = 0.002) in patients from the treatment groups, but not insulin resistance. CONCLUSIONS: Dietary consumption of pistachio nuts as a snack has beneficial effects on glycemic control, blood pressure, obesity, and inflammation markers in diabetic patients.

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“…Diabetes mellitus is a chronic disease that affects about 5-10% of the world population [4,19]. Diet and weight control are the basic principles in the treatment of type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pistachio Nut Supplementation on Blood Glucose in Patients with Type 2 Diabetes: A Randomized Crossover Trial

et al. 2014

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“…alloxan monohydrate (Sigma Chem. Co., St. Louis, MO, USA), freshly prepared in distilled water before use (Vinuthan et al 2007; Kameswararao et al 2003). Alloxan induces diabetes mellitus in rats via selective pancreatic beta cells toxicity (Matsuhisa et al 1997;Ezeigbo 2010), typifying the type 1 diabetes mellitus (T1DM) condition.…”

Section: Possible Anti-diabetic Activities Of D Edulis Under Acute Omentioning

confidence: 99%

Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats.

Okolo¹,

Ejere²,

Chukwuka³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: The fruit extract of Dacryodes edulis (D. edulis), the African pear or plum, a tree indigenous to the humid tropics has been used for managing wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in decoctions administered to diabetic patients. However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model. Materials and Methods: Sub-toxic doses between 400 and 1600mg/kg were orally administered sub-chronically to alloxan-induced diabetic rats for 15 days and compared to glibenclamide (2.5mg/kg). The glycaemia levels, body weights, lipid profile, blood urea, creatinine and liver enzyme levels were measured. Basic histology of the pancreatic tissue was also performed to examine the effects on the pancreas as possible mechanistic lead. Results: Oral acute dosing of D. edulis hexane extract decreased blood glucose levels, while sub-chronic treatment of the extract down-regulated significantly hyperglycaemia, total cholesterol, triglycerides, LDL-C, ALT and ALP levels. However, the HDL-C levels increased significantly. Histopathological examination of the pancreatic tissues after sub-chronic treatment showed that glibenclamide and the highest dose of the extract 1600mg/kg restored the afore-damaged pancreatic β-cell architecture. Conclusion: Our findings portend that D. edulis hexane fruit extract possesses hypoglycaemic and hypolipidaemic activities as well as restoration of the pancreatic architecture without any obvious untoward hepatic damages, suggesting that its use in the management of the diabetes may be valid.

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“…The disease affects approximately more than 5% of the world's population (Kameswararao et al, 2003). Apart from the hyperglycaemia, several factors including dyslipidemia or hyperlipidemia are involved in the micro-and macrovascular complications associated with the disease; a major cause of morbidity and death (Taskinen, 1993).…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Activities of the Methanol Leaf Extracts of <i>Hymenocardia acida</i> (Tul.) in Alloxan-Induced Diabetic Rats

Ezeigbo¹,

Asuzu²

2012

Afr. J. Trad. Compl. Alt. Med.

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The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg -2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls. IntroductionDiabetes mellitus (DM) is a multi-factorial disease characterised by hyperglycaemia and lipoprotein abnormalities (Scoppola et al., 2001). The disease affects approximately more than 5% of the world's population (Kameswararao et al., 2003). Apart from the hyperglycaemia, several factors including dyslipidemia or hyperlipidemia are involved in the micro-and macrovascular complications associated with the disease; a major cause of morbidity and death (Taskinen, 1993). Diabetic disease is increasing rapidly and vast amounts of resources are spent in all countries (Verspohl, 2002). Currently available therapies for diabetes include insulin and various oral anti-diabetic agents such as sulfonylureas, biguanides, alpha-glucosidase inhibitors, troglitazones, etc; used either as monotherapy or in combination to achieve better glycaemic conditions. Each of the above oral agents suffers from various serious adverse effects. Furthermore, the overall search for anti-diabetic agents has not been rewarded with marketable novel agents in the last two decades (Dewanjee et al., 2008); attempts are still made to find such drugs.Plants however have played a significant role in the introduction of new therapeutic agents. Metformin was discovered from Galega officinalis, a medicinal plant. In Nigeria, traditional medicine occupies a unique position in health care delivery, especially among the rural populace. However, the activities of herbalists are surrounded with a lot of secrecy and lack of scientific procedure, hence the need to standardise the practice of traditional medicine.Folkloric uses of the leaves of Hymenocardia acida include the treatment of conditions like diarrhoea (Tona et al., 1999), malaria (Vonthron-Sénécheau et al., 2003), dysentery, diabetes mellitus by the Igede people of Benue State (Igoli et al., 2005), Wounds and Skin diseases (Igoli et al., 2003) and is also shown to have anti-tumour and anti-HIV activities (Muanza et al., 1995). The present investigation was therefore intended to examine the potential anti-diabetic activity of the methanolic leaf extracts of H. acida using alloxan induced-diabetic rat model. Materials and Methods AnimalsOut bred Albino Wistar rats of both sexes weighing 185 -278 g were purchased from the Laboratory Animal Facility of the Department of Veterinary Physiology and Pharmacology, University of ...

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Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats

Cited by 113 publications

References 15 publications

Effects of Pistachio Nut Supplementation on Blood Glucose in Patients with Type 2 Diabetes: A Randomized Crossover Trial

Effects of Pistachio Nut Supplementation on Blood Glucose in Patients with Type 2 Diabetes: A Randomized Crossover Trial

Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats.

Anti-Diabetic Activities of the Methanol Leaf Extracts of <i>Hymenocardia acida</i> (Tul.) in Alloxan-Induced Diabetic Rats

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