Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats

Patil, Raju N; Patil, Ravindra; Ahirwar, Bharati; Ahirwar, Dheeraj

doi:10.1016/s1995-7645(11)60025-4

Cited by 57 publications

(24 citation statements)

References 19 publications

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“…The control group (C), received saline (0.5 ml/100 g); the HE group received HE (125, 250 or 500 mg/kg) (Patil et al, 2011); and the glibenclamide group received glibenclamide (10 mg/kg) (Zhao et al, 2011). All drugs were diluted with saline (0.9%) in established doses and administered orally by gavage in a volume of 0.5 ml/100 g body weight (Trovato et al, 1996;Diehl et al, 2001).…”

Section: Oral Glucose Tolerance Curvementioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tSolidago chilensis Meyen, Asteraceae, is traditionally used to treat inflammation. However, phytochemical and pharmacology investigations are lacking. This study evaluated the hypoglycemic and hypolipidemic effects of hydroalcoholic extract from S. chilensis aerial parts in rats. In oral glucose tolerance tests the rats received saline (0.5 ml/100 g) in control group (C), hydroalcoholic extract (125, 250 or 500 mg/kg p.o.; n = 6) or glibenclamide (10 mg/kg p.o.; n = 6). After 30 min, glucose (4 g/kg) was administered. Rats treated with hydroalcoholic extract 500 demonstrated decreased glucose levels at 180 min (−22.1%), when compared with group C, similar to glibenclamide. Moreover, treatment with hydroalcoholic extract 500 significantly increased the glycogen content in the liver and soleus muscle, and hydroalcoholic extract 250 specifically inhibited the enzyme maltase when compared with group C. Furthermore, all hyperglycemic rats treated with hydroalcoholic extract (125, 250 and 500) exhibited an accentuated decrease in total cholesterol levels (−36.8%, −36.7% and −41.3%, respectively). Our results suggest that hypoglycemic and hypolipidemic effects of hydroalcoholic extract could be associated with increased production and release of insulin as well as with insulinotropic and antioxidant effects.

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Section: Oral Glucose Tolerance Curvementioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Schneider

Sachett

Schönell

et al. 2015

Revista Brasileira de Farmacognosia

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“…Cardiovascular diseases are listed as the cause of death in 65% people suffering from diabetes. [28][29][30][31] From this point of view, it is encouraging that a regular administration of HERM extract for 21 days nearly normalized lipid profile in diabetic animals. The dose of 800 mg/kg not only lowered TC, TG and LDL but also enhanced the cardio-protective lipid HDL.…”

Section: Discussionmentioning

confidence: 73%

Anti-diabetic, Hypolipidemic and Anti-oxidant Activities of Hydroethanolic Root Extract of Rhus Mysurensis Heyne in Streptozotocin Induced Diabetes in Wistar Male Rats

Lamba¹,

Sulakhiya²,

Kumar³

et al. 2014

Phcog J.

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Objectives: The present study was designed to investigate the potential role of hydroethanolic root extracts of Rhus mysurensis (HERM) in the treatment of diabetes along with its antioxidant and hypolipidemic effects were studied in streptozotocin induced diabetes in Wistar rats. Methods: In this study, the anti-diabetic, hypolipidemic and anti-oxidant activities of hydroethanolic root extract of Rhus mysurensis was evaluated by using STZ induced diabetic rats at a dose of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. daily for 21 days. Blood glucose levels and body weight were monitored at specific time intervals, and different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein were also assessed in the experimental animals. Results: Oral administration of hydroethanolic root extracts of Rhus mysurensis (HERM) 400 and 800 mg/kg for 21 days significantly decreased the blood glucose level and considerably increased the body weight of diabetic rats. Daily oral treatment with HERM for 3 weeks resulted in reduced serum cholesterol, and triglycerides and improved HDL-cholesterol levels when compared to the diabetic control group. HERM significantly decreased thiobarbituric acid reactive substances (TBARS) and significantly increased superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 21 days of treatment. Conclusions: Hydroethanolic root extract of Rhus mysurensis showed significant anti-diabetic, hypolipidemic and anti-oxidant activities, which provide the scientific proof for its traditional claims. The results also put forward that the HERM is promising for development of standardized phytomedicine for the treatment of diabetes mellitus.

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“…Some of these phytochemical compounds revealed to be present in this extract include terpenes,saponins,tannins and alkaloids [7] . These constituents may in part be responsible for the observed significant activity of this extract either singly or in synergy with one another [11] .These constituents may in part be responsible for the observed significant activity of this extract either singly or in synergy with one another. Alloxan is reported to selectively destroy insulin secretory毬-cells to impair insulin secretion and function [17] .…”

Section: Discussionmentioning

confidence: 83%

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens

Akpan

Okokon

Offong

2012

Asian Pacific Journal of Tropical Biomedicine

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Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats

Abstract: Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.

Cited by 57 publications

References 19 publications

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Hypoglycemic and hypolipidemic effects of Solidago chilensis in rats

Anti-diabetic, Hypolipidemic and Anti-oxidant Activities of Hydroethanolic Root Extract of Rhus Mysurensis Heyne in Streptozotocin Induced Diabetes in Wistar Male Rats

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens

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