Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats

Ansari, Mohd Nazam; Saeedan, Abdulaziz S.; Bajaj, Sakshi; Singh, Lakhveer

doi:10.1007/s13205-021-02728-5

Cited by 5 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 Chemically induced DM is able to mimic the physiological and biochemical derangements in the actual disease. 52 Oral administration of the extract resulted in appreciable improvement in glucose homeostasis in diabetic mice. As shown in Table 6, the crude extract possessed antihyperglycemic activity when administered to Stz-induced diabetic mice at all test doses.…”

Section: Discussionmentioning

confidence: 96%

Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity

Sisay¹,

Andargie²,

Molla³

2022

JEP

View full text Add to dashboard Cite

Background: Despite modern therapeutic armamentaria, DM remains a 21st-century public health menace. Novel phytomedicines are a rapidly expanding focus of research. The juice of Dorstenia barnimiana roots has long been used for the treatment of diabetes mellitus in traditional Ethiopian medicine, but its efficacy has not been supported by in vitro or in vivo scientific study. To investigate this, the present work was performed. Methods: In this experimental study, simple random sampling was applied. Healthy male mice were used in normoglycemic and oral glucose-tolerance test (OGTT) models. Streptozotocin (IP, 150 mg/kg)-administered diabetic male mice were utilized. Animals were randomly divided into five groups of six each. Group I received 10 mL/kg distilled water, groups II-IV received 100 (DB100), 200 (DB200), and 400 (DB400) mg/kg crude extract, respectively, and group V received glibenclamide 5 mg/kg. A sham group (group VI) was added that received 10 mL/kg distilled water. All treatments were given orally. FBG, serum-lipid profiles, and body-weight changes were then measured. In vitro α-amylase inhibitory activity was also evaluated. Results:The doses were atoxic up to 2,000 mg/kg. There was α-amylase inhibition activity of 67.52% at 500 μg/mL with an IC 50 of 4.595 μg/mL. The OGTT revealed an antihyperglycemic effect of the crude extract. This was not attributed to a hypoglycemic side effect. In the diabetic mouse model, it shrank FBG levels remarkably. There were also significant reductions in serum TC, TGs, VLDL-C, and LDL-C. Nevertheless, HDL-C and body-weight levels returned. Conclusion:The present study confirmed the safety and promising in vivo antidiabetic and antidyslipidemic activity of D. barnimiana, thus corroborating the traditional claim.

show abstract

Section: Discussionmentioning

confidence: 96%

Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity

Sisay¹,

Andargie²,

Molla³

2022

JEP

View full text Add to dashboard Cite

show abstract

“…(8) (9) Barleria cristata Linn (Family: Acanthaceae), often known as Kala Bansa. (10) It is a shrub that is extensively distributed in the subtropical Himalayas, Sikkim, Khasi Hills, central, and southern India. (11) As a traditional herbal medicine, the plant's parts were used to treat conditions like asthma, bronchitis, and skin conditions.…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents Screening, TLC, And GC-MS Analysis Of Barleria Cristata Linn. Leaves Methanolic Extract

V¹

2022

Journal of Pharmaceutical Negative Results

View full text Add to dashboard Cite

Barleria cristata Linn is an ornamental plant that grows on the sides of roads in India, China, and other countries. This plant belongs to the family Acanthaceae. In India, it is used as herbal medicine and is called Kala Bansa. It has an ancient legacy of application in folk medicine, particularly for the treatment of tuberculosis and snake bites. The purpose of the present study was a preliminary phytochemical analysis, Thin-Layer Chromatography (TLC) analysis and Gas chromatography-mass spectroscopy (GCMS) analysis of the methanol extract of Barleria cristata Linn leaves. The preliminary phytochemical screening finding revealed compounds like Alkaloids, Glycosides, Flavonoids, Carbohydrates, Proteins, and amino acids, and Reducing sugars. Thin-layer chromatography (TLC) of the methanolic extract was executed for 5 essential phytoconstituents Alkaloids, Flavonoids, Saponins, Glycosides, and Triterpenoids. The leaf extract of this plant was analyzed using GCMS. This report revealed the 15 compounds. The bioactive chemicals were found by comparing the retention time and peak area with the literature. Barleria cristata possess various medicinal properties, so more research must be done on its traditional claims.

show abstract

Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

Okoduwa,

Mhya,

Abdulwaliyu

et al. 2024

Phytochem Rev

View full text Add to dashboard Cite

Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats

Cited by 5 publications

References 29 publications

Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity

Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity

Phytoconstituents Screening, TLC, And GC-MS Analysis Of Barleria Cristata Linn. Leaves Methanolic Extract

Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

Contact Info

Product

Resources

About