Evaluation of Antidiabetic Activity of <i>Rumex vesicarius</i> in Streptozotocin Induced Diabetic Albino Rats

Reddy, Nadiminti Satish; Vidyasabbani,; Pravanthi, B.; Laxmi, B. Vijaya; Harika, B.

doi:10.5958/2321-5836.2016.00023.9

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in-vitro study from previously studied indicated that alkaloids from Catharanthus roseus (L.) G. Don demonstrated antidiabetic activity through increasing glucose uptake [ 70 ]. The previous investigations revealed that the related species Rumex vesicarius showed significant antidiabetic activity in a dose-dependent fashion [ 78 ]. Rumex rothschildianus , another species under the family Polygonaceae, also showed antidiabetic activity in vitro study [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts of Rumex abyssinicus Jacq: (Polygonaceae) in Swiss Albino Mice

Adugna

Adinew

Getahun

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. Diabetes Mellitus isa chronic metabolic disorder that required long-lasting treatment. In Ethiopian traditional medicine practices, abundant plants have been used for the treatment of diabetes mellitus for a long period. The root of Rumex abyssinicus is employed for the treatment of diabetes mellitus by Ethiopians. This study aimed to investigate the antidiabetic activity of the crude extract of Rumex abyssinicus root in Swiss albino mice. Methods. Cold maceration technique and hydro methanolic (80% methanol) solvent with occasionally shaking were employed during the crude extraction processes. To evaluate the antidiabetic activity of the crude extract, normoglycemic, glucose-loaded, and streptozotocin-induced diabetic models were used. In each model, the overnight fasted mice were randomly divided into five groups for normoglycemic and glucose-loaded models as a negative control, positive control, and three tested groups, whereas, in streptozotocin-induced diabetic models, the mice were grouped into six groups like one diabetic and one normal negative control groups, three diabetic tested groups, and one diabetic positive group. Each group comprised six mice. For all models, the tested groups received the crude extract at 100, 200, and 400 mg/kg doses, both diabetic and nondiabetic negative control groups received 10 ml/kg distilled water, and positive groups received 5 mg/kg glibenclamide. Results. The crude extract of the plant did not show any sign of toxicity up to 2000 mg/kg dose. In normoglycemic and oral glucose tolerance tests, the crude extract significantly ( p < 0.01 ) reduced the blood glucose level at 200 and 400 mg/kg doses. In the streptozotocin-induced diabetes models, a significant effect was observed at all tested doses. Conclusion. The finding of this study revealed that the crude extract of the plant owned antidiabetic activity and supports the traditional use of Rumex abyssinicus root for the treatment of diabetes mellitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts of Rumex abyssinicus Jacq: (Polygonaceae) in Swiss Albino Mice

Adugna

Adinew

Getahun

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Another plant found in some of these herbal medicines, namely Rumex vesicarius, decreased blood sugar levels in streptozotocin-induced diabetic rats at different doses and protected pancreatic cells from streptozotocin induced-damages. The research concluded that the ethanolic extract of Rumex vesicarius might produce antidiabetic effects by increasing insulin secretion by the pancreas (Reddy et al, 2016).…”

Section: Shahmentioning

confidence: 99%

Studies on antidiabetic herbal formulations available in the herbal stores of Karachi, Pakistan

Shah¹

2022

J Pharm Pharmacogn Res

View full text Add to dashboard Cite

Context: Diabetes mellitus is a condition, which is characterized by persistent hyperglycemia, abnormal functioning of insulin and difficulty in the metabolism of carbohydrates, fats and proteins. Antidiabetic medicines of herbal origin are widely consumed in Pakistan. Therefore, there was a need to generate data on antidiabetic herbal formulations manufactured and marketed in Pakistan. Aims: To develop a list of Pakistani manufactured antidiabetic herbal products and the most common herbal ingredients found in them. Methods: Antidiabetic herbal formulations were collected from the renowned herbal stores of Karachi, Pakistan, and their ingredients were checked. The most common herbal ingredients found in them were determined, and the possible constituents responsible for the antidiabetic action of these herbs were discovered. Results: A total of 15 herbal antidiabetic products were collected from the herbal stores. The most common herbs found in them include Syzygium cumini, Gymnemma sylvestre, Aloe vera, Nigella sativa, Acacia nilotica, Commiphora myrrha, Portulaca oleracea, Punica granatum, Rhus coriaria, Coriandrum sativum, Trigonella foenum-graecum, Bambusa bambos, Holarrhena antidysenterica, Swertia changii, Curcuma longa and Rumex vesicarius. The constituents responsible for antidiabetic activity include alkaloids, polysaccharides, glycosides, secoiridoid, phenolic acids, flavonoids, terpenoids, saponins and volatile oil. Conclusions: The herbs incorporated in these formulations have proven antidiabetic effects; therefore, these formulations can produce significant results in the management of diabetes. More research on each of these formulations is needed to confirm the potency of all these herbal products.

show abstract

Rumpictuside A: Unusual 9,10-anthraquinone glucoside from Rumex pictus Forssk

El‐Kashak

Elshamy

Mohamed

et al. 2017

Carbohydrate Research

View full text Add to dashboard Cite

Evaluation of Antidiabetic Activity of Rumex vesicarius in Streptozotocin Induced Diabetic Albino Rats

Cited by 6 publications

References 0 publications

Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts of Rumex abyssinicus Jacq: (Polygonaceae) in Swiss Albino Mice

Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts of Rumex abyssinicus Jacq: (Polygonaceae) in Swiss Albino Mice

Studies on antidiabetic herbal formulations available in the herbal stores of Karachi, Pakistan

Rumpictuside A: Unusual 9,10-anthraquinone glucoside from Rumex pictus Forssk

Contact Info

Product

Resources

About