Evaluation of antidesmone alkaloid as a photosynthesis inhibitor

Sampaio, Olívia Moreira; Lima, Murilo Marinho de Castro; Veiga, Thiago André Moura; King-Dı́az, Beatriz; Silva, Maria Fátima das Graças Fernandes da; Lotina‐Hennsen, Blas

doi:10.1016/j.pestbp.2016.04.006

Cited by 17 publications

(24 citation statements)

References 24 publications

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“…The same J band was observed when the mixture of quinolone alkaloids was submitted to the assays ( Figure 4 B), which confirms that Compounds 6 – 8 also behave like 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), inhibiting the acceptor side of the PSII [ 10 ]. The Chl a experiment also showed the appearance of the I band near 30 ms ( Figure 4 C), which exclusively refers to the efficiency of the quinone pool.…”

Section: Resultssupporting

confidence: 57%

“…The Chl a fluorescence assay is a widely used tool to evaluate the photosynthetic apparatus in plants submitted to different stresses, as well as to provide detailed information about the structure and function of PSII [ 10 , 20 ]. For this experiment, all alkaloids were evaluated at 150 and 300 μM.…”

Section: Resultsmentioning

confidence: 99%

“…Many of these metabolites have attracted biological and pharmacological interest, demonstrating antifungal, phytotoxic, and antidotal activities [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. In this context, the effect of the natural products as photosynthesis inhibitors has been efficiently evaluated [ 10 , 11 , 12 ]. The photosynthetic process is divided into three parts: the initial light-harvesting process and local charge separation, proton-coupled electron transfer, and multielectronic redox catalysis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

et al. 2018

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Eight alkaloids (1–8) were isolated from Ruta graveolens, and their herbicide activities were evaluated through in vitro, semivivo, and in vivo assays. The most relevant results were observed for Compounds 5 and 6–8 at 150 μM, which decreased dry biomass by 20% and 23%, respectively. These are significant results since they presented similar values with the positive control, commercial herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Based on the performed assays, Compound 5 (graveoline) is classified as an electron-transport inhibitor during the light phase of photosynthesis, as well as a plant-growth regulator. On the other hand, Compounds 6–8 inhibited electron and energy transfers, and are also plant-growth inhibitors. These phytotoxic behaviors based on acridone and quinolone alkaloids may serve as a valuable tool in the further development of a new class of herbicides since natural products represent an interesting alternative to replace commercial herbicides, potentially due their low toxicity.

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

et al. 2018

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“…Intact chloroplasts were obtained from spinach leaves ( Spinacia oleracea L.) as previously described [18–21] . The Chl content was measured spectrophotometrically through a chloroplast suspension in a solution of 400 mM sucrose, 5 mM MgCl 2 , 10 mM KCl, 30 mM tricine‐KOH and pH 8.0 [45] …”

Section: Methodsmentioning

confidence: 99%

“…Thus, these results indicated that acetogenins could be useful for designing photosynthesis-inhibitory herbicides, once photosynthesis is essential for plant survival, and the process can be summarized by the conversion of light into CO 2 , which in turn originates sugars and consequently natural products are produced. [17] Many natural products such as alkaloids, [18][19][20][21] coumarins, [22] terpenoids, [23] depsides [24] and polyketides, [25] have been already reported as inhibitors of photosynthesis. Based on this, continuing our search for new models for herbicides, this work represents only the second report of the effect of these kind of natural products on the light reactions of photosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acetogenins from Annona coriacea on the in Vitro Reactions of Photosynthesis

Severino

Simão

Junqueira

et al. 2020

Chemistry & Biodiversity

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Our search for candidates for photosynthesis inhibitors is allowing us to report the effect of two acetogenins identified in Annona coriacea Mart. leaves, ACGÀ A and ACGÀ B, a non-adjacent bis-THF and a mono-THF types, respectively. This is an important class of natural products which presents biological properties such as anticancer, neurotoxic, larvicidal and insecticidal. However, this is only the second report associated to its herbicidal activity. Their mechanisms of action on the light reactions of the photosynthesis were elucidated by polarographic techniques. Compounds inhibited the noncyclic electron transport on basal, phosphorylating, and uncoupled conditions from H 2 O to methyl viologen (MV); therefore, they act as Hill reaction inhibitors. Studies on fluorescence of chlorophyll a (ChL a) indicated that they inhibited the acceptor side of PSII between P680 and PQ-pool, exactly as the commercial herbicide DCMU does.

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Evaluation of Chalcone Derivatives as Photosynthesis and Plant Growth Inhibitors

Pádua

Souza

Sales

et al. 2021

Chemistry & Biodiversity

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We report the evaluation of chalcone derivatives as photosystem II (PSII) and plant growth inhibitors. Chalcone derivatives were evaluated as PSII inhibitors through Chl a fluorescence measurement. (E)-Chalcone (6a) and (E)-3-(4-bromophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (6j) showed the best results, reducing the performance index on absorption basis parameter (PI abs ) by 70 %. Additionally, the decrease of TR 0 /RC and ET 0 / RC parameters indicates that the chalcone derivatives limited the number of active PSII reaction centers and the amount of trapped energy within them. Compounds 6a and 6j both act as post-emergent herbicides at 50 μM, reducing the root biomass of the Ipomoea grandifolia weed by 72 % and 83 %, respectively, corroborating the fluorescence results. The selectivity against weeds as compared to valuable crops by compounds 6a and 6j were evaluated employing Zea mays and Phaseolus vulgaris plants. In these, our newly synthesized compounds showed no effects on biomass accumulation of roots and aerial parts when compared to the control, providing valuable evidence for the role of these compounds as selective inhibitors of the growth of undesired weeds.

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Evaluation of antidesmone alkaloid as a photosynthesis inhibitor

Cited by 17 publications

References 24 publications

Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

Effects of Acetogenins from Annona coriacea on the in Vitro Reactions of Photosynthesis

Evaluation of Chalcone Derivatives as Photosynthesis and Plant Growth Inhibitors

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