Evaluation of Antidepressant-like Effect of Olax Subscorpioidea Oliv. (Olacaceae) Extract in Mice

Abstract

Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is indicated in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer. Based on the folkloric use in the management of mental illness, antidepressant activity of Olax subscorpioidea (6.25?50?mg/kg, i.?p.) was investigated using forced swimming, tail suspension, yohimbine induced lethality and reserpine induced depression tests. The results showed that, Olax subscorpioidea produced significant dose dependent reduction in immobility time in forced swimming [F (5, 24)=17.22, p<0.0001] and tail suspension [F (5, 24)=14.94, p<0.0001] tests without causing changes in locomotor activity in open field test. It was also found that Olax subscorpioidea significantly reduced diarrhea in reserpine model of depression [F (5, 24)=10, p<0.0001]. None of the doses potentiated yohimbine induced lethality in mice. In conclusion Olax subscorpioidea possessed antidepressant action, thus justifying its use in the management of mental illness.

HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana

“…Interestingly, in both acetylcholinesterase and butyrylcholinesterase inhibitory activities of ON-Cr, all the concentrations (31.25, 62.50, 125, 250, 500 and 1000 μg/mL) demonstrated % inhibition values not significantly different in comparison to galantamine (standard drug) at the same concentration ( P > 0.05 at 95% confidence interval). Previously, Olax Subscorpioidea is also reported to possess neuroprotective, anxiolytic and anti-depressant properties [ 18 , 21 ]. Significant results noticed in the antioxidant and anticholinesterase assays of ON-Cr may be attributed to the predominant presence of Gallic acid derivatives among the identified compounds (Table 2 ), which is a common poly phenol and strong antioxidant having promising neuroprotective potentials [ 68 , 69 ].…”

Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

“…Mouse was viewed as stable when it inactively hung with bar without any endeavors to get away. 23 -26…”

“…Mouse was viewed as stable when it inactively hung with bar without any endeavors to get away. [23][24][25][26] Acute Toxicity Study of O bracteatum Rules of Organization for Economic Cooperation and Development were pursued to execute acute lethality studies. 27 Mice (22-42 g) were partitioned into 5 different groups, comprising of 5 mice in each group.…”

Ethnobotanical Survey of Medicinal Plants Used as Aphrodisiacs in Bauchi Local Government Area

“…Previous studies have shown that the plant displayed Antinociceptive [104], anti-ulcer [96], antimicrobial [94] and anti-protease [105] activities. Recently, The Antidepressant effects of the plant were also reported [106]. Olax subscorpioidea leaf possesses hypoglycaemic potential [107] and antifungal activity [108].…”