Evaluation of anticonvulsant activity of ethanolic extract of leaves of Ocimum sanctum (tulsi) in albino rats

Manu, Gangadhar; Padmanabha, Shivaraju Thiruganahalli; Thippeswamy, Chandrakantha; Ravishankar, M.

doi:10.5455/njppp.2017.7.0308122032017

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Group IV received 400mg/kg of ethanolic extract of Psidium guajava. [55]. Oral administration of all medications was done one hour prior to the onset of seizures.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Review of Plants and Natural Products with Antiepileptic Effects

Ohanme,

Iganga,

Ofor

et al. 2024

J. Compl. Altern. Med. Res.

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Both recurrent and spontaneous seizures are indications of epilepsy, a disorder of the brain. Around the world, as many as sixty-five million individuals could be influenced, and 80 percent of cases are found in low-income countries. Medicinal herbs are widely utilized to treat and manage epilepsy and convulsions due to their unique healing properties. Through greater research and clinical use, medicinal plants are gaining attention on a global scale because of their potent therapeutic effects and few adverse effects. The development of innovative plant-based antiepileptic/anticonvulsant medications has drawn a lot of interest from the pharmaceutical industry. This article provides an overview of the study on medicinal plants that have been demonstrated to have antiepileptic and anticonvulsant qualities. It provides pharmacological and molecular mechanism of action data for the crude extracts and related active ingredients evaluated in preclinical research for the treatment of epilepsy and convulsions, and it works as a guide for the development of future pertinent studies in this area. Articles about ethnopharmacological and antiepileptic studies on plants or natural products from the most recent and recent years were obtained from PubMed, Web of Science, and Scopus, among other sources, using keywords related to epilepsy, medicinal plants, natural products, etc. Many plant species are commonly utilized in Asian and African countries to treat epilepsy and convulsions. It has also been discovered that natural chemicals derived from these medicinal plants may possess antiepileptic and anticonvulsant qualities. These compounds can be broadly classified as terpenoids, alkaloids, coumarins, flavonoids, and saponins. The antiepileptic capabilities of plant extracts and their active ingredients can be classified according to their ability to affect the GABAergic and glutamatergic systems, act as antioxidants, exhibit anti-neuroinflammatory characteristics, and provide neuroprotection. Additionally, we highlight the potential use of various medicinal plants as a therapeutic intervention for refractory epilepsy, as they may be able to pharmacologically reduce epilepsy and cognitive impairment. The research highlights how herbal remedies used in traditional medicine are a great source of potential candidates for antiepileptic drugs. This demonstrates and validates the antiepileptic and anticonvulsant qualities of various therapeutic herbs, which could inspire further study. To fully comprehend the ideas of metabolic processes, toxicity, clinical trials, structural optimization, and change, further research is still necessary.

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“…Group IV received 400mg/kg of ethanolic extract of Psidium guajava. [55]. Oral administration of all medications was done one hour prior to the onset of seizures.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Review of Plants and Natural Products with Antiepileptic Effects

Ohanme,

Iganga,

Ofor

et al. 2024

J. Compl. Altern. Med. Res.

View full text Add to dashboard Cite

show abstract

“…Several study models exist among which includes the Pentylenetetrazole (PTZ), maximal electroshock (MES). The MES induced seizure are abolished by medicinal agents that block voltage-gated + Na channels such as iminostilbenes and hydatoins and felbamates while PTZ induced seizures are prevented by 2+ drugs that block The T-type Ca current in thalamus, like sodium valproate and diazepam drug that enhanced GABA 8,9 receptor in the brain .…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

2022

PSNNJP

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Background: Diketones and α,β-unsaturated ketone are useful intermediates for the synthesis of antiepileptic moieties. Epilepsy is a neurological disorder that affects about fifty million people worldwide. The aim of the study was to assess benzylideneacetophenone analogues for their potential antiepileptic effects in mice. Methods: The compounds used in the pharmacological assay which include; 4-G), were assayed using three models; Strychnine, Pentylenetetrazole (PTZ) and Maximal Electroshock (MES). The samples were given at 500, 1000 and 1500 mg/kg while standard drug diazepam and distilled water were given at 5 mg and 10 ml/kg intraperitoneal respectively. Convulsion inducing agents (Strychnine 2 mg/kg and PTZ, 100 mg/kg) were administered intraperitoneal 1hour after the administration of test samples while MES model electroconvulsive shock was applied using electroconvulsive machine. Results:The samples (A-G) showed significant (P<0.03, 0.003, 0.0007 and 0.0001) effect in delaying onset of seizure compared to control in strychnine model, while in PTZ model samples (A-F) evaluated at 500,1000 and 1500 mg/kg are equipotent at all the doses by significantly (P<0.0001) and sample G (P<0.0007) reduced the onset of seizure compared to control. However in MES model samples (A-F and G) evaluated at 500, 1000 and 1500 mg/kg are equipotent at all the doses by significantly (P<0.0001; 0.0007), reduced the duration of seizure compared to control respectively. Conclusion: Benzylideneacetophenone analogues showed various effects in control of seizure in all the models used.This effect is due to delayed onset and reduction of seizure duration. The samples could act by stimulating the glycine, Gamma Aminobutyric acid (GABA) receptor, inhibition of GABA Aminotransferase and prolong inactivation of sodium ion channel.

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Formulation and Evaluation of Polyherbal Cream

Ganji¹,

Chandrika

Mounika

et al. 2022

RJTCS

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Herbal skin creams are mainly intended for beautification of skin. The main aim of the present research work is to prepare a face cream using different herbs and the prepared cream is evaluated for stability and anti bacterial activity. The herbs used in the formulation (F1, F2, and F3) are flowers of Clitoria ternatea, leaves of Azadirachta indica and Ocimum sanctum. The formulated cream is evaluated for the various parameters like organoleptic properties, pH, stability, consistency, skin irritation, and antibacterial properties. F1 formulation has shown good stability and antibacterial properties compared to marketed cream.

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Evaluation of anticonvulsant activity of ethanolic extract of leaves of Ocimum sanctum (tulsi) in albino rats

Cited by 3 publications

References 4 publications

Pharmacological Review of Plants and Natural Products with Antiepileptic Effects

Pharmacological Review of Plants and Natural Products with Antiepileptic Effects

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

Formulation and Evaluation of Polyherbal Cream

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