Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

Abstract

The present investigation was aimed to study an anticonvulsant activity of ethanolic extract of Desmodium triflorum (L.) DC., Fabaceae, in mice. Animal models of epilepsy namely the pentylenetetrazole (PTZ), isoniazid or isonicotinic hydrazide (INH) and maximal electroshock induced convulsion (MES) were used to evaluate the anticonvulsant effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the PTZ induced convulsion, ethanolic extract of D. triflorum (EEDT) 400 mg/kg significant delayed the onset of convulsion, reduced the duration of convulsion and reduced mortality. Similarly a dose of 800 mg/kg of EDDT significantly delayed the onset of convulsion, reduced the duration of convulsion and showed 33.33% protection in mice against INH induced convulsion. Further no mortality was found. Both the doses reduced hind limb tonic extension (HLTE) phase of MES induced convulsion in mice. The pretreated EEDT showed significant inhibition of lipid peroxidation and increases the reduced glutathione level in mice brain tissue. The results revealed that D. triflorum possesses a significant dose dependent anticonvulsant activity.

Protective effect of Grewia asiatica leaves extract in animal models of epilepsy and anxiety

“…This model is acute model of seizures. Various studies using MES and PTZ induced seizures did not report effect of male and female animals on seizures severity [ [19] , [20] , [21] , [22] ]. Similar results were observed in the present study.…”

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“…The enhancement of the GABAergic neurotransmission is reported to antagonize seizures, while the inhibition of the neurotransmission boosts seizures. The protection of mice against PTZ-induced seizures by the standard anticonvulsant drugs, phenobarbitone and diazepam is expected since many authors have demonstrated that they describe their anticonvulsant activities by increasing GABA-mediated inhibition 40 .…”

Evaluation of the Anticonvulsant Activity of the Hydroethanolic Extract of Crinum scillifolium Bulbs (Amaryllidaceae) in Experimental Animals

“…About 75-80% of the world's population and especially of the developing countries uses medicinal plants for the treatment of epilepsy because of better compatibility with the human body and lesser side effects [6]. Actually, medicinal plants to be an important source of traditional medicines to treat epilepsy.…”