Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion

Abstract

BACKGROUND: Antiphospholipid syndrome (APS) is a major reproductive complication in women, which is characterized by recurrent fetal loss, thrombosis, and thrombocytopenia in association with anticardiolipin antibodies (aCL). AIMS: To analyze the prevalence of aCL and antiphosphatidylserine antibodies (aPS) in relation to pregnancy failures in women with the history of recurrent spontaneous abortion. SETTINGS AND DESIGN: A sequential study of 155 patients, who had three or more recurrent spontaneous abortions, was carried out. METHODS AND MATERIALS: Women with unexplained recurrent pregnancy loss in first trimester were selected for this study. Anticardiolipin antibodies IgG and aPS IgG were detected in the serum by the enzyme linked immunosorbent assay method. STATISTICAL ANALYSIS: Percentage calculation was carried out. Two-tailed t-test was performed to know the significance of aCL and aPS total population. RESULT: The levels of aCL IgG and aPS IgG were detected as 40% (62) and 19% (18), respectively in women with history of recurrent abortion. CONCLUSION: Anticardiolipin antibody is found to be the most important factor for recurrent abortion. In addition, women with negative aCL are having positive for another antiphospholipid antibodies like aPS, which may involve in recurrent abortion.

Prevalence of common thrombophilia markers and risk factors in Indian patients with primary venous thrombosis

“… 10 The presence of aCL and LA in various Indian studies has been reported to be 5.3 to 21% and 6.25%, respectively. 3 , 4 , 12 Some authors have described concordance rates for positive LA and aCL results ranging from 60 to 90%, 13 but in this study none of the ten positive samples showed such concordance. Therefore, we are of the opinion that all samples must be tested for both aCL and LA.…”

Frequency of Anticardiolipin Antibodies in Women with Recurrent Fetal Loss

“…Similarly in 2005 Archunan and his colleagues reported 40% positive anticardiolipin antibodies cases in women with history of recurrent fetal losses. (Archunan, 2005). In another study done by Creagh et al (1999), sample size of 35 women with history of recurrent fetal losses showed 17.1% positive anticardiolipin antibodies (Creagh, 1999).…”