Evaluation of anticancer effects of frankincense on breast cancer stem‐like cells

Kamalabadi-Farahani, Mohammad; Bitaraf, Fateme Sadat; Atashi, Amir; Jabbarpour, Zahra

doi:10.1002/cnr2.1693

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…It’s interesting to note that circ-Foxo3 expression was discovered to be considerably higher during cancer cell death [ 9 ]. In our previous works apoptotic resistance of breast CSCs have been confirmed [ 14 ]. Accordingly down regulation of Circ-Foxo3 in breast CSCs may be a reason for apoptotic resistance of these cells.…”

Section: Discussionmentioning

confidence: 91%

Downregulation of circ-Foxo3 in breast cancer stem-like cells

2023

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Objective Cancer cells having stem cell characteristics are linked to metastasis and relapse in breast cancer. Circ-Foxo3, as a circular RNA, has been linked to the breast cancer lethal traits. This study’s objective was to assess circ-Foxo3 expression in breast cancer stem-like cells. After isolation from tumor mass, breast cancer cells were subjected to the reliable in vitro assay of spheroid formation to determine the presence cancer stem cells (CSCs). We used a quantitative real-time polymerase chain reaction to examine circ-Foxo3 expression in spheroids. Results Circ-Foxo3 expression was significantly downregulated in spheroid-forming tumor cells, according to our data. This study demonstrated that breast CSCs have downregulated circ-Foxo3 expression, which may allow these cells to evade apoptosis. A precise analysis of this circRNA’s role could be exploited to develop focused therapeutic approaches to fight breast CSCs.

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Section: Discussionmentioning

confidence: 91%

Downregulation of circ-Foxo3 in breast cancer stem-like cells

2023

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Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

Zou,

Luo,

Wang

et al. 2024

Journal Cellular Physiology

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Triple‐negative breast cancer (TNBC) is a highly aggressive and metastatic malignancy with poor treatment outcomes. The interaction between the tumor microenvironment (TME) and breast cancer stem cells (BCSCs) plays an important role in the development of TNBC. Owing to their ability of self‐renewal and multidirectional differentiation, BCSCs maintain tumor growth, drive metastatic colonization, and facilitate the development of drug resistance. TME is the main factor regulating the phenotype and metastasis of BCSCs. Immune cells, cancer‐related fibroblasts (CAFs), cytokines, mesenchymal cells, endothelial cells, and extracellular matrix within the TME form a complex communication network, exert highly selective pressure on the tumor, and provide a conducive environment for the formation of BCSC niches. Tumor growth and metastasis can be controlled by targeting the TME to eliminate BCSC niches or targeting BCSCs to modify the TME. These approaches may improve the treatment outcomes and possess great application potential in clinical settings. In this review, we summarized the relationship between BCSCs and the progression and drug resistance of TNBC, especially focusing on the interaction between BCSCs and TME. In addition, we discussed therapeutic strategies that target the TME to inhibit or eliminate BCSCs, providing valuable insights into the clinical treatment of TNBC.

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Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Jahangiry,

Lashanizadegan,

Pourhosseini

et al. 2024

Biometals

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Schiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized in order that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of MTT assay was compared using the 1-way ANOVA and Tukey test. Results showed that the complexes were stable in aqueous buffer, pH 8. The extrinsic fluorescence emission of the plasmid and CT-DNA was quenched while interacting with the complex. The complex had an IC50 of 72.47 μM against MCF-7 cells. The ANOVA and Tukey analysis of MTT data demonstrated a statistically significant difference between groups (P<0.0001). The minimum inhibitory concentrations (MIC) of the complex for E. coli and S. aureus were 300 and 200 μg/mL, with 96.3 % and 95.2 % biofilm growth inhibition at 250 μg/mL, respectively. The sample concentrations contributing to 50% radical inhibition in the 1,1-diphenyl-2picrylhydrazyl (DPPH) test for curcumin, ligand, and palladium (II) complex were 33.62, 21.27, and 51.26 μM, respectively. The results suggest that the complex interaction with DNA is one of the potential mechanisms in the elimination of cancer cells and bacteria in the planktonic and biofilm. On the other hand, while stability in aqueous buffer at pH 8 increases, modified curcumin antioxidant effect decreases.

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Evaluation of anticancer effects of frankincense on breast cancer stem‐like cells

Cited by 5 publications

References 33 publications

Downregulation of circ-Foxo3 in breast cancer stem-like cells

Downregulation of circ-Foxo3 in breast cancer stem-like cells

Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

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