Evaluation of Antibiotic Irrigation Versus Saline Irrigation in Reducing the Long-Term Incidence and Severity of Capsular Contraction After Primary Augmentation Mammoplasty

Drinane, James J.; Kortes, Matthew J.; Bergman, Ronald S.; Folkers, Bryan L

doi:10.1097/sap.0000000000000302

Cited by 33 publications

(16 citation statements)

References 32 publications

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“…, mainly S. epidermidis (ranging from 17.8 to 84%). The hypothesis that bacteria play a role in the development of capsular contracture has also been investigated by administrating antibiotics prophylactically or postoperatively, which has yielded contradictive results [16, 20, 28–35]. The aforementioned studies suggest that bacteria might play a role in the development of capsular contracture.…”

Section: Discussionmentioning

confidence: 99%

PCR Characterization of Microbiota on Contracted and Non-Contracted Breast Capsules

et al. 2019

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Background The aetiology of capsular contracture around breast implants remains unclear. The leading theory is that a subclinical infection around the implant plays a role in the development of capsular contractions. Several studies found associations between the presence of bacteria and the occurrence of capsular contraction. However, it is unclear whether detected bacteria originate from the breast capsule, breast glandular tissue or skin contamination. Moreover, this has never been investigated with molecular techniques. The aim of this study was to assess the bacterial microbiota on breast capsules, glandular tissue and skin using a highly sensitive PCR assay. Materials and Methods Fifty breast capsules were collected during implant removal or replacement. Ten specimens of glandular breast tissue and breast skin were collected in females who were undergoing reduction mammoplasty. A sample specimen (4 mm) was sterilely obtained from all tissues. All specimens were analysed by IS-pro, a 16S–23S interspace region-based PCR assay. Results Low numbers of Staphylococcus spp. (four species in four capsules) were found on breast capsules. There was no difference in bacterial presence between normal and contracted capsules. The skin of the breast-harboured Streptococcus spp. and Staphylococcus spp . while the glandular tissue was sterile. Conclusion The low numbers of bacteria found on the capsules are most likely caused by contamination during capsule removal. More and larger studies are needed to investigate the bacterial presence on breast capsules using a PCR assay. This is the first study in which breast capsules have been studied using a highly sensitive PCR assay. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

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Section: Discussionmentioning

confidence: 99%

PCR Characterization of Microbiota on Contracted and Non-Contracted Breast Capsules

et al. 2019

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“…1 Ralstonia pickettii has also been identified in a disproportionately high percentage of breast implants from patients with BIA-ALCL. 5 Additionally, while there is a growing body of evidence implicating bacterial colonization of devices in the development of CC, including a strong correlation between Baker grade and positive breast implant and TE cultures 3 and a reduction in CC rates after breast implant placement with the use of antibiotic pocket irrigation or impregnated mesh strategies, 32–35 these findings are not universally consistent among reports, 36,37 and the latter are limited to a mean of 2 years of follow-up or less. 33–35 An elegant swine model, however, has demonstrated causation between S. epidermidis infection and CC.…”

Section: Discussionmentioning

confidence: 99%

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants

Walker¹,

Pinkner²,

Pinkner³

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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“…[94][95][96] Contrary to evidence favoring antibiotic pocket irrigation to attenuate CC rates, 20,22 recent cohort studies comparing triple antibiotic to saline irrigation demonstrate no difference in CC rates. 94,97,98 Elucidating a relationship between biofilm formation and CC merits further study.…”

Section: Discussionmentioning

confidence: 99%

Histologic, Molecular, and Clinical Evaluation of Explanted Breast Prostheses, Capsules, and Acellular Dermal Matrices for Bacteria

et al. 2015

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Evaluation of Antibiotic Irrigation Versus Saline Irrigation in Reducing the Long-Term Incidence and Severity of Capsular Contraction After Primary Augmentation Mammoplasty

Abstract: There was no difference between triple antibiotic and saline irrigation in the incidence or severity of capsular contracture at 2.8 years follow-up when high-quality surgical technique is used.

Cited by 33 publications

References 32 publications

PCR Characterization of Microbiota on Contracted and Non-Contracted Breast Capsules

PCR Characterization of Microbiota on Contracted and Non-Contracted Breast Capsules

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants

Histologic, Molecular, and Clinical Evaluation of Explanted Breast Prostheses, Capsules, and Acellular Dermal Matrices for Bacteria

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