Evaluation of antibacterial, antifungal and modulatory activity of methanol and ethanol extracts of Padina sanctae-crucis

Abstract

Background: Multi-resistant microorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found. Methods:The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms. Results: Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively. Conclusions:The results showed a moderate modulatory effect against some microorganisms studied.

Antifungal and Antioxidant Activities of Vernonia Chalybaea Mart. ex DC. Essential Oil and their Major Constituent β-caryophyllene

“…This result indicates that these natural products have an effect on strains of the dermatophyte T. rubrum, suggesting that modulatory activity tests should be conducted with other filamentous fungi that are human pathogens. A possible mechanism for the inhibition of microbial growth can be the hydrophobic nature of the constituents of natural products, which can act on the plasma membrane, making it more permeable to antifungal agents and thereby affecting the biochemical apparatus of the respiratory chain and of energy production [52]. β-caryophyllene is a hydrophobic molecule, which presents low molecular weight; these properties facilitate the permeability in the cellular membrane of the fungi, being able to be involved in the mechanism of action of inhibition of Brazilian Archives of Biology and Technology.…”

Antimicrobial Action of Compounds from Marine Seaweed

“…coli, the ethyl acetate was a greater inhibitor of S. aureus and the ethanol extract against S. aureus and P. aeruginosa. Nogueira et al [ 110 ] reported modulation of antibiotic activity between the Padina sanctae-crucis ethanolic and methanolic extracts and E. coli and S. aureus , and a moderate modulatory effect against these microorganisms and P. aeruginosa , Candida tropicalis and C. kruseim. Stabili et al [ 65 ] confirmed the activity against human pathogenic bacteria and yeasts of lipid extracts of one Mediterranean alga with the difussion disk method.…”

Cytotoxicity, antifungal and antioxidant activities of the essential oil from Eupatorium ballotifolium Kunth (Asteraceae)

“…Such compounds can act on the plasma membrane, causing it to become more permeable to antifungal agents, affecting the mitochondrial respiratory chain and cellular energy production. Thus, this mechanism can occur due to combined action of the antifungals with natural products at subinhibitory concentrations (Nogueira et al, 2014;Tintino et al, 2014). This is the first report of modulatory activity of a standard antifungal drug combined with EOEB.…”