Evaluation of antibacterial activity of sesquiterpene Ar- Turmerone from Curcuma soloensis Val. rhizomes

Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo; Munasah, Gesti

doi:10.1088/1757-899x/578/1/012060

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…This compound has also been found in Aglaia odorata Lour (Joycharat et al 2014). The growth inhibition test performed by others has revealed that artumerone has no or low inhibitory effect on E. coli growth (Lee 2006 andMarliyana et al, 2019), which may be due to its relatively lower concentration in their extract. Still other have determined that the essential oil of C. Longa and the extract of Jathyadi Thailam, both containing ar-tumerone and other compounds, possess antibacterial effect on MRSA (Mandrika et al, 2021 andSrisayam et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

Actinomycetes of Howz Soltan Lake and their metabolite diversity in Iran

Salehghamari

Moradi

Sardabi

et al. 2022

Preprint

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Saline environments are largely unexplored sources for actinomycetes with the potential to produce biologically active secondary metabolites. A total of 34 actinomycete strains from water, sediments and mostly rhizosphere (82%) were collected from different sites of Howz Soltan Lake in Iran. Based on phylogenetic analysis, the isolated strains belonged to the genera Streptomyces, Nocardia and Saccharomonospora. Among the isolated actinomycetes, several strains had valuable biotechnological applications such as growth inhibition of human tumor cells. The results of cytotoxic assay revealed strain act9 having the most potent extract (19.716 ± 5.72 µg/ml) against the MDA-MB-231 human breast cancer cell. Also 38% of the strains had an antimicrobial activity against some pathogenic and nonpathogenic microorganisms. The ethyl-acetate extract of act18 showed the most antibacterial effect against Staphylococcus aureus, MRSA, and was further analyzed by GC/MS. Ar-tumerone (26.41%) and Butyl isodecyl phthalate (21.77%) were the main constituents detected in the extract.. This is the first time this compound is being detected in a prokaryote. Act18 showed the most 16s rRNA sequence similarity to Streptomyces youssoufiensis. In addition, a number of the isolates produced different enzymes including lipase, amylase, protease, gelatinase, urease and lecetinase. Also, the plant growth promoting activity of some actinomycete strains were shown. Some of the strains belonging to the genera Streptomyces and Nocardia increased the seed germination, stem length and the number of Echium leaves during the 20 days. Consequently, it was concluded that actinomycetes isolated from these saline lake habitats are potentially valuable for biotechnological applications.

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Section: Discussionmentioning

confidence: 98%

Actinomycetes of Howz Soltan Lake and their metabolite diversity in Iran

Salehghamari

Moradi

Sardabi

et al. 2022

Preprint

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“…These are DGEA2 reported by Padmavathi et al (2014) , DGEA8 by Beavers et al (2019) , Again, for the AC CEF, 2 out of total 7 compounds detected, were reported with antibacterial effects ( Table 4 ). These are DGAC6 by Marliyana et al (2019) and DGAC7 by Padmavathi et al (2014) .…”

Section: Discussionmentioning

confidence: 99%

Metabolite Profiling of Malaysian Gracilaria edulis Reveals Eplerenone as Novel Antibacterial Compound for Drug Repurposing Against MDR Bacteria

et al. 2021

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With a continuous threat of antimicrobial resistance on human health worldwide, efforts for new alternatives are ongoing for the management of bacterial infectious diseases. Natural products of land and sea, being conceived to be having fewer side effects, pose themselves as a welcome relief. In this respect, we have taken a scaffolded approach to unearthing the almost unexplored chemical constituents of Malaysian red seaweed, Gracilaria edulis. Essentially, a preliminary evaluation of the ethyl acetate and acetone solvent extracts, among a series of six such, revealed potential antibacterial activity against six MDR species namely, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella enterica, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, and Bacillus subtilis. Detailed analyses of the inlying chemical constituents, through LC-MS and GC-MS chromatographic separation, revealed a library of metabolic compounds. These were led for further virtual screening against selected key role playing proteins in the virulence of the aforesaid bacteria. To this end, detailed predictive pharmacological analyses added up to reinforce Eplerenone as a natural alternative from the plethora of plausible bioactives. Our work adds the ongoing effort to re-discover and repurpose biochemical compounds to combat the antimicrobial resistance offered by the Gram-positive and the -negative bacterial species.

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“…Cho đến nay, hoạt tính kháng H. pylori của các hợp chất ar-turmerone, curzerene và zerumbone chưa được báo cáo. Ar-turmerone được chứng tỏ không có hoạt tính kháng khuẩn 70 trong khi curzerene và zerumbone biểu hiện hoạt tính kháng khuẩn phổ rộng đối với các loài vi khuẩn Gram âm và Gram dương 71,72 . Zerumbone cũng được chứng minh có tác động ức chế và làm suy giảm biofilm của các loài vi khuẩn S. aureus, E. coli, Pseudomonas aeruginosa và nấm Candida albicans 73 .…”

Section: Hiệu Suất Thu Tinh Dầuunclassified

Anti-Helicobacter pylori activities of essential oils extracted from rhizomes of four species of Zingiberaceae family

2022

Sci. Tech. Dev. J. - Nat. Sci.

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Evaluation of antibacterial activity of sesquiterpene Ar- Turmerone from Curcuma soloensis Val. rhizomes

Cited by 11 publications

References 14 publications

Actinomycetes of Howz Soltan Lake and their metabolite diversity in Iran

Actinomycetes of Howz Soltan Lake and their metabolite diversity in Iran

Metabolite Profiling of Malaysian Gracilaria edulis Reveals Eplerenone as Novel Antibacterial Compound for Drug Repurposing Against MDR Bacteria

Anti-Helicobacter pylori activities of essential oils extracted from rhizomes of four species of Zingiberaceae family

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