Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants

Moussaoui, Fadila; Alaoui, Tajelmolk

doi:10.1016/j.apjtb.2015.09.024

Cited by 91 publications

(57 citation statements)

References 14 publications

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“…The antibacterial potential of the selected plants observed may be due to the presence of tannins, flavonoids, and terpenoids which were reported to have various pharmacological activities, including antibacterial activity. 46 Previous studies on antibacterial potential of the selected plants against the tested bacteria are as follows: E elephantina, 13,[47][48][49][50] D rotundifolia. 51 The MIC for E elephantina methanolic and acetone extracts against S aureus were 0.16 mg/mL and 0.320 mg/mL, respectively.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Assessment of Selected Medicinal Plants Used by the Bapedi Community in South Africa for Treatment of Bacterial Infections

Kudumela

Masoko

2018

J Evid Based Complementary Altern Med

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There is very little scientific information on indigenous plants used for medicinal purposes. Therefore, the aim of the study was to evaluate the antibacterial and antioxidant activities of the leaves of Commelina africana, Elephantorrhiza elephantina, Dombeya rotundifolia, and the whole plant excluding the roots of Schkuhria pinnata indigenous medicinal plants from the Limpopo Province, which may be used for the treatment in humans infected with bacterial pathogens. The screening of different phytoconstituents using standard methods revealed the presence of terpenoids, flavonoids, tannins, and saponins. The total phenolic, tannin, and flavonoid content were estimated using spectrophotometric methods. D rotundifolia had the highest amounts of phenol (259.00 ± 2.65 mg of gallic acid equivalent [GAE]/g), tannin (330.33 ± 15.63 mg of GAE/g), and flavonoid (19.90 ± 0.75 mg of quercetin equivalent [QE]/g) content, while S pinnata had the least. All the plants had antibacterial activity against Escherichia coli and Pseudomonas aeruginosa with the bioautography method. The microbroth dilution assay revealed antibacterial activity with minimum inhibitory concentration values raining from 0.02 to 2.50 mg/mL. D rotundifolia had the highest antioxidant activity in both the free radical scavenging and ferric reducing power methods. S pinnata and C africana extracts had high antibacterial activity, while D rotundifolia had high antioxidant activity, which made them potential plants for isolation of bioactive compounds and possible application in the pharmaceutical industry.

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Section: Resultsmentioning

confidence: 99%

In Vitro Assessment of Selected Medicinal Plants Used by the Bapedi Community in South Africa for Treatment of Bacterial Infections

Kudumela

Masoko

2018

J Evid Based Complementary Altern Med

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“…Examples have started to appear in the literature, and the results have been good in many cases, validating this as an alternative that deserves more research in order to transform the employment of the essential oils and its components with the antibacterials in an option to treat infections produced by multi-resistant micro-organisms 12,13,14,15 . There are also examples of synergistic effects of individual components of the essential oils and antibiotics against bacteria and the yeast Candida albicans, pointing that those compounds can be valid alternatives to revert the resistance of microorganisms against the drug presently used 16,17 .…”

Section: Quick Response Codementioning

confidence: 92%

Untitled

2019

IJPSR

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The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics amoxicillin and gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, being the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA strain, whereas for the sensitive strain one combination showed synergy with amoxicillin and additionally one combination showed the additive effect with gentamicin. To confirm the observed results, the combination that had the lowest concentration of amoxicillin and the monoterpene were assayed by the time-kill curve method. An even lower concentration of the terpene that did not show cytotoxicity against human cells was also assayed. The results obtained confirmed those of the checkerboard method and synergy was also observed for the non-cytotoxic concentration of (S)-cis-Verbenol analyzed. This opens interesting possibilities about the use of purely natural products in combination with antibiotics to treat infections produced by sensitive and resistant bacteria.

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“…45 Recent studies, such as those by Moussaoui and Alaoui and Sanhueza et al, report an increase of antimicrobial activity of natural antimicrobial compounds in combination with conventional antimicrobial peptides. 46,47 Another way to increase antimicrobial efficiency is to add surfactants to the disinfectant formulation. Surfactants generally act as a detergent agent by decreasing the surface tension in several disinfectant, antiseptic and preservative solutions.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Chemical Composition of Black Spruce (Picea mariana) Bark Extracts and Their Potential as Natural Disinfectant

St-Pierre

Blondeau

Bourdeau

et al. 2019

Industrial Biotechnology

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The valorization of residual forest biomass from sawmills is an economic and ecological opportunity in Que´bec. With specialized metabolites and biological activities, several residues from Que´bec's tree species could have commercial potential. This study aims to study the antimicrobial efficacy of extracts from bark residues to determine their potential as a natural disinfectant. We first performed a quantification of phenolic metabolites by colorimetric tests which showed higher flavonoids and proanthocyanidins content (>27.88 mmol catechin equivalents (CE)/100 g of bark extract and >3.90 mmol CE/100g of bark extract respectively) in black spruce extracts compared to balsam fir, quaking aspen and white birch. Extraction with water (WE) followed by fractionation with ethyl acetate yielded a fraction enriched with oligomeric proanthocyanidins (OPF). WE and OPF antimicrobial activity on Escherichia coli using the broth microdilution and the dilution-neutralization methods (AOAC 960.09) demonstrated an increased antimicrobial potency with OPF. A minimal inhibitory concentration and a minimum bactericidal concentration of 0.83 mg/mL and 4.44 mg/mL respectively as well as a microbial reduction of 4.83 log CFU/ mL (3% w/w with 10 min contact) and ‡5.09 log CFU/mL (1.5% w/w with 120 min contact time) were obtained. Compounds characterization using UPLC-QTOF-MS allowed to putatively identify nine antimicrobial compounds in the OPF. Taxifolin, dihydroxykampferol and andrographolide seemed to be associated with the increase of the antimicrobial activity of this fraction. Downloaded by 44.224.250.200 from www.liebertpub.com at 07/07/20. For personal use only. 7. Salmon D. Ressources et industries forestie`res: Portrait statistique: Québec, Ministère des Forêts, de la Faune et des Parcs; 2016. 8. Paes TL, David A, E. HR et al. Black spruce trees from fire-origin stands have higher wood mechanical properties than those from older, irregular stands.

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Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants

Cited by 91 publications

References 14 publications

In Vitro Assessment of Selected Medicinal Plants Used by the Bapedi Community in South Africa for Treatment of Bacterial Infections

In Vitro Assessment of Selected Medicinal Plants Used by the Bapedi Community in South Africa for Treatment of Bacterial Infections

Untitled

Chemical Composition of Black Spruce (Picea mariana) Bark Extracts and Their Potential as Natural Disinfectant

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