Evaluation of antiarthritic and immunomodulatory activity of Barleria lupulina

Mazumder, Papiya Mitra; Mondal, A; Sasmal, D.; Arulmozhi, S.; Rathinavelusamy, Paramaguru

doi:10.1016/s2221-1691(12)60425-0

Cited by 17 publications

(10 citation statements)

References 21 publications

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“…Traditionally, B. lupulina was used to treat several diseases, including treating snake bites, dog bites, swelling, bleeding wounds, rheumatism, herpes simplex, and herpes zoster [ 10 , 11 ]. Studies have documented that B. lupulina has medicinal values, including anti-inflammation [ 12 ], antiviral [ 13 , 14 ], antibacterial [ 11 , 15 , 16 ], antidiabetic [ 17 ], cytotoxic [ 18 , 19 ], antidiuretic, and antiarthritic activity [ 20 , 21 ]. Several studies have also shown that the species possesses highly potential antioxidants and bioactive compounds used in treatments of various diseases and health issues [ 10 , 15 , 19 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Ismail-Suhaimy

Gani

Zaidan

et al. 2021

Plants

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Barleria lupulina Lindl. (Acanthaceae) as an ornamental plant has been widely used in folklore medicine due to its abundancy in polyphenolic compounds. The present study examined conditions for optimal extraction of antioxidants from B. lupulina leaf extracts by using the microwave-assisted extraction (MAE) method. The effects of ethanol concentrations, microwave power, and extraction time on total phenolic content (TPC), total flavonoid content (TFC), 1-diphenyl-2-picrylhydrazyl (DPPH), and 2,20-azino-bis (3-ethylbenzothizoline-6-sulfonic acid) (ABTS) were investigated by single-factor experiments. Response surface methodology (RSM) was applied to observe interactions of three independent variables (ethanol concentrations, microwave power, and extraction time) on the dependent variables (TPC, TFC, DPPH, and ABTS) to establish optimal extraction conditions. Quadratic polynomial equations in all experimental models yielded favorably with fitted models with R2 and R2adj of more than 0.90 and a non-significant lack of fit at p > 0.05. The optimal conditions for the extraction of antioxidant activity were established at 80% (v/v) ethanol, 400 W, and 30 s with TPC (238.71 mg gallic acid equivalent (GAE)/g sample), TFC (58.09 mg QE/g sample), DPPH (87.95%), and ABTS (89.56%). Analysis by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) successfully identified four new phenylethanoid glycoside compounds in the species.

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Section: Introductionmentioning

confidence: 99%

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Ismail-Suhaimy

Gani

Zaidan

et al. 2021

Plants

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“…Traditionally, leaves of this plant are used to treat snake bites, dog bites, swelling, bleeding wounds and rheumatism. The extracts of the plant also possess anti-HSV-2 activities [9], ameliorate secondary complications of diabetes including cataract [10,11], antiarthritic [12], anti-inflammatory [13], antimicrobial [14], anti-clastogenic, anti-tumor, and anti-cancer activities besides having radiation protection [15].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antibacterial and Cytotoxic Properties of Barleria lupulina Lindl. Extracts

Kumari¹,

Dubey²

2016

J Plant Pathol Microbiol

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(India) during the month of June 2014, and identified by the experts of the department (specimen identification No Bot. and micro/199). The plant leaves were washed with running tap water to remove the adhered dust, dirt and unwanted particles from their surfaces. The leaves were shade dried at room temperature for 15 days and separately homogenized in domestic blender to get fine powders. The powders were stored in airtight container at room temperature for further studies. Bacterial cultures Five standard human enteric pathogenic bacteria viz. Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 27853, Pseudomonas aeruginosa ATCC 25922, Klebsiella pneumoniae MTCC 432 and Salmonella typhi MTCC 733 were procured from the Laboratory of the Departmental of Botany & Microbiology, Gurukula Kangri University. All the pathogens were sub cultured on nutrient agar slants and preserved at 4ºC for further study.

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“…Pathological changes in RA are hyperplasia of synovial membrane, infiltration of inflammatory cells and neovascularisation, which result into cartilage erosion and articular destruction [5]. The goal of treatment for rheumatoid arthritis patients are to eliminate symptoms, slow disease progression, and optimize quality of life [6]. Therefore, before starting the treatment of RA certain goals must be kept in mind such as relief of algesia, reduction of inflammation, protection of articular structure, maintenance of function and control of systemic involvement [7].…”

Section: Introductionmentioning

confidence: 99%

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Ashwlayan

Nimesh

2018

Journal of Bone Biology and Osteoporosis

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Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto immune disease, affecting people predominantly between the ages of 20-60 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. This is a long lasting disease that can affect joints in any part of the body, most commonly the hands, wrists, and knees. Popularity of medicinal plants is increasing day by day due to side effects of allopathic medicines. Herbal medicinal plants have been used as major sources of cure of human diseases since time immemorial. Today, one fourth of world population depends on traditional medicine and 80% of the population relies on indigenous herbal medicinal plants. Even today most of the people lives in different developing countries depend on the plant derived medicines for the first line of primary health care because of least or no side effects.

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Evaluation of antiarthritic and immunomodulatory activity of Barleria lupulina

Cited by 17 publications

References 21 publications

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Optimizing Conditions for Microwave-Assisted Extraction of Polyphenolic Content and Antioxidant Activity of Barleria lupulina Lindl.

Phytochemical Analysis and Antibacterial and Cytotoxic Properties of Barleria lupulina Lindl. Extracts

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

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