Evaluation of antiangiogenic and antiproliferative effects of sorafenib by sequential histology and intravoxel incoherent motion diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model

Abstract

1 J. Magn. Reson. Imaging 2017;45:270-280.

Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study

“…A possible reason may be the big limitation of D * , which results from uncertainty and very poor reproducibility (Wu et al, 2015; Nougaret et al, 2016; Yang et al, 2016). We found that D * displayed a large degree of dispersion during post-processing computations, maybe because of a high variation in D * within brain tissues due to the blood–brain barrier; f usually shows a small value in brain tissues.…”

Intravoxel incoherent motion MRI as a means to measure in vivo perfusion: A review of the evidence

“…Further, in rat prostate cancer, Zhang et al found that the distribution of perfusion fraction coincided with the distribution of a histologic perfusion marker, consisting of a dye injected shortly before cutting off the blood flow to the tumor and tumor excision. Interestingly, in a hepatocellular carcinoma xenograft mouse model, a positive correlation between f and MVD ( r = 0.57, p = 0.009) was found in the control group, but after anti‐angiogenic treatment no positive correlation between f and MVD was found ( r = 0.44, p = 0.054); however, note that the p ‐value is just above statistical significance. Similarly, in 12 patients suffering from rectal carcinoma, a significant positive correlation was found between f and the vascular area fraction in the carcinoma ( r = 0.60, p < 0.05) and the surrounding normal fat ( r = 0.60, p < 0.05), but the correlation was not significant in the surrounding normal rectum ( r = 0.47, p = 0.21), and no positive correlation was found in any region in nine patients who received chemoradiotherapy treatment …”

“…In a nasopharyngeal carcinoma mouse model, Cui et al found a significant decrease in f and D * in a group treated with antiangiogenic therapy compared with a control group, as soon as 1 day after treatment. In a hepatocellular carcinoma xenograft mouse model, Yang et al found a significant decrease in f at 7 days after antiangiogenic treatment, and a significant increase at 21 days. A similar significant increase in f at 2 weeks after antiangiogenic therapy was also found by Lewin et al in a group of patients with hepatocellular carcinoma, in which increased f was correlated with early response and longer survival .…”

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

“…The longer the echo time, the greater the signal decays at low b values, which indicates the increase of estimated PF. This phenomenon is due to the faster transverse relaxation of the tissue compartment signal (i.e., the liver), which increases the signal fraction of Quant Imaging Med Surg 2017;7(1): [59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] qims.amegroups.com Table S1. the vascular component.…”