Evaluation of anti-thyroglobulin antibodies in pregnant women in Area IV of Asturias

González, Silvia García; García, F.J.; Rodríguez, Ricaurte; Martín, A.; Díaz, Lucía; Blanco, Jessica Ares; Menéndez, Edelmiro

doi:10.1530/endoabs.56.p1067

Cited by 2 publications

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“…A study involving pregnant patients obtained data that contradicted the importance of TGAb testing. The work showed that there are TPOAb-negative and TGAb-positive patients with normal thyroid function who may need treatment and recommended that TGAb be measured in TPOAb-negative pregnant patients 27 . Another group showed that pregnant patients with TPOAb positivity and patients with only TGAb positivity had different outcomes for their children 28 .…”

Section: Discussionmentioning

confidence: 99%

Metabolomic analysis of follicular fluid from women with Hashimoto thyroiditis

Bastos

Chiamolera

Silva

et al. 2023

Sci Rep

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Hashimoto thyroiditis is an autoimmune disease characterized by hypothyroidism and a high level of anti-thyroid autoantibodies. It has shown to negatively impact female fertility; however, the mechanisms are unclear. Ovarian follicular fluid appears to be the key to understanding how Hashimoto thyroiditis affecst fertility. Thus, we aimed to evaluated the metabolic profile of follicular fluid and antithyroid autoantibody levels in the context of Hashimoto thyroiditis. We collected follicular fluid from 61 patients, namely 38 women with thyroid autoantibody positivity and 23 women as negative controls, undergoing in vitro fertilization treatment. Follicular fluid samples were analyzed using metabolomics, and thyroid autoantibodies were measured. Fifteen metabolites with higher concentrations in the follicular fluid samples from Hashimoto thyroiditis were identified, comprising five possible affected pathways: the glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and sphingolipid metabolism pathways. These pathways are known to regulate ovarian functions. In addition, antithyroglobulin antibody concentrations in both serum and follicular fluid were more than tenfold higher in women with Hashimoto thyroiditis than in controls. Our data showed that the metabolic profile of follicular fluid is altered in women with Hashimoto thyroiditis, suggesting a potential mechanistic explanation for the association of this disease with female infertility.

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Section: Discussionmentioning

confidence: 99%

Metabolomic analysis of follicular fluid from women with Hashimoto thyroiditis

Bastos

Chiamolera

Silva

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Studies have presented results that stimulate discussion about the clinical relevance of the TGAb dosage (Matalon et al ., 2003; González et al ., 2018; Teng et al ., 2022). A study involving pregnant patients obtained data that contradicted the importance of TGAb dosing.…”

Section: Discussionmentioning

confidence: 99%

“…The work showed that there are TPOAb-negative and TGAb-positive patients with normal thyroid function who may need treatment. The article also recommended that TGAb be measured in TPOAb-negative pregnant patients (González et al ., 2018). Another group showed that pregnant patients with TPOAb positivity and patients with only TGAb positivity had different outcomes for their children (Teng et al ., 2022).…”

Section: Discussionmentioning

confidence: 99%

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Follicular fluid metabolomic analysis in women with Hashimoto’s thyroiditis

Bastos

Chiamolera

Silva

et al. 2022

Preprint

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Hashimotos thyroiditis is an autoimmune thyroid disease characterized by hypothyroidism and a high level of anti-thyroid autoantibodies. This disease has been linked to a negative impact on female fertility, but the mechanisms are unclear. Ovarian follicular fluid appears to be the key to understanding how Hashimoto's thyroiditis can affect fertility. Therefore, we aimed to evaluate the follicular fluid metabolic profile and its relationship with anti-thyroid autoantibody levels. For this, we collected follicular fluid from a total of 61 patients undergoing in vitro fertilization treatment, comprising 34 women with thyroid autoantibody positivity and 18 negative controls. Follicular fluid samples were analysed using metabolomics and thyroid autoantibodies were measured. Follicular fluid samples from Hashimotos thyroiditis patients presented 15 metabolites with higher concentrations than those in controls, which indicates five possible affected pathways: the glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and sphingolipid metabolism pathways. These pathways are known to regulate ovarian functions. In addition, anti-thyroglobulin antibody concentrations were more than tenfold higher in women with Hashimotos thyroiditis than in controls, in both serum and follicular fluid. Our data showed that Hashimotos thyroiditis can change the metabolic profile of follicular fluid, suggesting a potential mechanistic explanation for the association of this disease with female infertility.

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Evaluation of anti-thyroglobulin antibodies in pregnant women in Area IV of Asturias

Cited by 2 publications

References 0 publications

Metabolomic analysis of follicular fluid from women with Hashimoto thyroiditis

Metabolomic analysis of follicular fluid from women with Hashimoto thyroiditis

Follicular fluid metabolomic analysis in women with Hashimoto’s thyroiditis

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