Evaluation of Anti-Oxidant Capacity of Root of Scutellaria baicalensis Georgi, in Comparison with Roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer

Chan, Enoch; Wong, Cynthia Ying-Kat; Wan, Chun-Wai; Kwok, Ching-Yee; Wu, Jianhong; Ng, Kar-Man; So, Chi-Hang; Au, Alice Lai-Shan; Poon, Chi‐Ming; Seto, Sai Wang; Kwan, Yiu Wa; Yu, Peter H.; Chan, Shun‐Wan

doi:10.1142/s0192415x10008263

Cited by 50 publications

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References 27 publications

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“…In traditional Chinese medicine (TCM), it is believed that food and medicine stem from the same origin but with different uses and applications (Chan et al, 2010). Therefore, it is common for Chinese people to incorporate different medicinal herbs into their diet to produce various "healthy" food recipes in order to achieve better taste, more attractive appearance and improved texture of the food and most importantly to improve health.…”

Section: Introductionmentioning

confidence: 99%

A review of the pharmacological effects of Arctium lappa (burdock)

et al. 2010

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Abstract. Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in Traditional Chinese Medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to "detoxify" blood in TCM term and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and anti-diabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects, and potent inhibitory effects on the growth of tumors such as the pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases like cancers, diabetes and AIDS have been reported. However, it is also essential to be aware of the side-effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock.

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Section: Introductionmentioning

confidence: 99%

A review of the pharmacological effects of Arctium lappa (burdock)

et al. 2010

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“…Various natural compounds are effective in suppressing AD like pathology through their properties as anti-oxidants (Dos Santos-Neto et al, 2006;Frank and Gupta, 2005). Our team has even shown that Panax ginseng has a high content of anti-oxidants (Chan et al, 2010a;Chan et 8 al., 2008). Panax ginseng's effect on cognitive performances were evaluated in consecutive AD patients (Lee et al, 2008).…”

Section: Improves Cognition In Alzheimer's Disease (Ad)mentioning

confidence: 93%

“…In traditional Chinese medicine (TCM), it is believed that food and medicine come from the same origin but with different uses and applications (Chan et al, 2010a). Therefore, it is common 4 for Chinese people to incorporate different TCM herbs into their diet to produce various "healthy" food recipes so as to achieve better taste, more attractive appearance and improved texture of the food and most importantly to improve health .…”

Section: Introductionmentioning

confidence: 99%

Panax ginsengRhodiola roseaandSchisandra chinensis

Chan

2011

International Journal of Food Sciences and Nutrition

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Panax ginseng (Ginseng), Rhodiola rosea (Hong Jing Tian) and Schisandra chinensis (Wu Wei Zi) are well-known herbs in traditional Chinese medicine (TCM). Recently, there have been a number of studies on these 3 herbs. This review discusses their active components and major pharmacological effects. For Panax ginseng, it has been shown to have an anti-inflammatory activity, affects pulmonary function and erectile dysfunction, improves cognition in patients with Alzheimer's disease and promotes sexual arousal in menopausal women as well as prevent cancer. For Rhodiola rosea, its effectiveness on alleviating depression and reducing fatigue are summarized in this review.Additionally, anti-cancer and other clinical effects of Schisandra chinensis are also discussed. These 3 herbs are considered as adaptogens as they bear multiple functions and their effects were found to be very different in subjects depending on the circumstances (age, gender, environment, diet, season, etc.). Thus, in most cases, the art of the TCM practitioner is to prescribe these herbs after a complete evaluation of patients' overall heath status.

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“…MCF-7 cells were seeded in 96-well microtiter plates at a density of 1x10 4 cells/well in 200 µl medium; the medium was replaced the following morning with 200 µl of fresh complete medium containing PME of different final concentrations. Cells were treated with PME for different times according to the experimental requirement, using DMSO as vehicle at a maximum concentration of 0.1%.…”

Section: Materials Pm Was Obtained From the Harbin Branch Of Pekingmentioning

confidence: 99%

“…Clinically, it has been utilized in the treatment of poliosis, hemopenia, inflammation, bacterial infections, hyperlipidemia, coronary heart disease, neurosis and other diseases commonly associated with aging (2,3). The medicinal effects of PM in the improvement of health conditions are possibly mediated by the antioxidant capacity of this herb (4). The genus PM is the source of a wide range of phenolic compounds, flavonoids, anthraquinones, stilbenes and tannins (5,6).…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of an extract of the root of Polygonum multiflorum Thunb. on MCF-7 human breast cancer cells and the possible mechanisms

Liu

2011

Mol Med Report

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Abstract. The root of Polygonum multiflorum Thunb. (PM) is utilized to treat many diseases associated with aging. Research also indicates that PM inhibits the proliferation of certain types of cancer cells. The aim of the present study was to evaluate the inhibitory effect of PM extract (PME) on the proliferation of MCF-7 cells and to investigate the underlying mechanisms. Inhibition of the proliferation of MCF-7 cells was determined by the MTT assay. Cell cycle distribution and apoptotic rates were evaluated by flow cytometry, and cell cycle and apoptosis-related protein expression was assessed by Western blotting. Apoptotic characteristics of MCF-7 cells were detected by transmission electron microscopy. The present study showed that PME at doses of 100, 150, 200 and 250 µg/ml significantly inhibited proliferation of MCF-7 cells in a time-and dose-dependent manner. Flow cytometry showed that the cell apoptotic rates were 9.1±1.67 and 17.7±2.93% after treatment with 100 and 200 µg/ml PME for 48 h, respectively. The proportions of cells in the G2/M phase were 37.9±1.47 and 42.0±1.71% after treatment with 100 and 200 µg/ml PME for 24 h, respectively. Western blot analysis showed that PME down-regulated the protein expression of Cdc25B and Cdc25C phosphatases accompanied by an increase in phospho-Cdk1, and PME promoted cytochrome c release from mitochondria into the cytosol to activate caspase-9. The present study demonstrated that PME inhibited MCF-7 cell proliferation by inducing cell cycle arrest in the G2/M phase and promoting cell apoptosis. The effects of PME on MCF-7 cells were associated with the modulation of the expression levels of proteins involved in the cell cycle and apoptosis. These data suggest that PME has promise as a treatment against breast cancer by inhibiting the proliferation of cancer cells. IntroductionNatural products, which are important sources of medicinal compounds, have been used as drugs to treat many diseases since ancient times. Particularly in the area of cancer, more than 60% of antitumor medicines on the market are based on natural products (1).The root of Polygonum multiflorum Thunb. (PM), a perennial vine-like herb, which is called He-shou-wu, has been widely used in traditional Chinese medicine (TCM) as a tonic and anti-aging agent for centuries. Clinically, it has been utilized in the treatment of poliosis, hemopenia, inflammation, bacterial infections, hyperlipidemia, coronary heart disease, neurosis and other diseases commonly associated with aging (2,3). The medicinal effects of PM in the improvement of health conditions are possibly mediated by the antioxidant capacity of this herb (4). The genus PM is the source of a wide range of phenolic compounds, flavonoids, anthraquinones, stilbenes and tannins (5,6). These constituents which possess biological activities in PM are called phytochemicals. Several studies have demonstrated that these phytochemicals from PM display high pharmacological efficiency, such as antioxidant capacity, anti-proliferative, anti-inflammatory, ...

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Evaluation of Anti-Oxidant Capacity of Root of Scutellaria baicalensis Georgi, in Comparison with Roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer

Cited by 50 publications

References 27 publications

A review of the pharmacological effects of Arctium lappa (burdock)

A review of the pharmacological effects of Arctium lappa (burdock)

Panax ginsengRhodiola roseaandSchisandra chinensis

Anti-proliferative effect of an extract of the root of Polygonum multiflorum Thunb. on MCF-7 human breast cancer cells and the possible mechanisms

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