Evaluation of anti-inflammatory-related activity of essential oils from the leaves and resin of species of Protium

Siani, Antonio C.; Ramos, Mônica Freiman de Souza; Menezes-de-Lima, Octávio; Ribeiro-dos-Santos, Ricardo; Fernadez-Ferreira, E; Soares, Renata Oliveira; Rosas, Elaine Cruz; Susunaga, G.S; Guimarães, Anderson Cavalcante; Zoghbi, M.G.B.; Henriques, Maria das Graças

doi:10.1016/s0378-8741(98)00148-2

Cited by 138 publications

(92 citation statements)

References 29 publications

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“…Some pharmacological studies using the oil resin verified the therapeutical efficacy, which, by their surprising results, proved their usefulness as anti-inflammatory, antinoceptive, antineoplasic and gastro protective (Oliveira et al, 2004a,b,c;Siani et al, 1999a). The oil composition of the aerial parts and resin of P. heptaphyllum have been previously reported from a specimen collected in two regions of Brazil: Manaus in the North (Siani et al, 1999a,b;Zoghbi & Maia, 1995) and Ceará in the Northeast (Bandeira et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In popular medicine, this species is considered an important therapeutic agent which is used as anti-inflammatory, analgesic, expectorant and healing of wounds. It is also used in the paint industry and covering of boats (Costa, 1975;Corrêa, 1987;Pott & Pott, 1994;Siani et al, 1999a). Other applications include production of oil resins rich in essential oils used as incense or insect repellent (Pernet, 1972;Corrêa, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae)

et al. 2007

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Essential oils from leaves and fruits of Protium heptaphyllum collected in Tamandaré beach -Pernambuco/Brazil were analysed by GC/MS and tested for toxicity and repellent effect against the two spotted spider mite (Tetranychus urticae). The major constituent identified in the fruits was a-terpinene (47.6 %) whereas oil from leaf contained mainly sesquiterpenes such as 9-epi-caryophyllene (21.4 %), trans-isolongifolanone (10.7 %) and 14-hydroxi-9-epi-caryophyllene (16.7 %). The fruit oil was found to be more effective against the mite when compared to the leaf oil. Both showed mortality properties and oviposition deterrence in higher concentration (10 Fl.l -1 air), but only the essential oil from fruits induced repellence on T. urticae. KEY-WORDSProtium heptaphyllum, essential oil, Tetranychus urticae, acaricidal activityComposição química e atividade acaricida do óleo essencial das folhas e frutos de Protium heptaphyllum (Aubl.) Marchand (Burseraceae) 1 RESUMO O óleo essencial das folhas e frutos de Protium heptaphyllum coletada em Tamandaré-Pernambuco foi analisado por CG/EM e testado sua toxicidade e efeito repelente contra ácaro rajado (Tetranychus urticae). O constituinte majoritário identificado nos frutos foi a-terpineno(47,6 %) enquanto que nas folhas foram os sesquiterpenos 9-epi-cariofileno (21,4 %), trans-isolongifolanona (10,7 %) and 14-hidroxi-9-epi-cariofileno (16,7 %)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae)

et al. 2007

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“…p-Cymene (p-isopropyltoluene, 1) is a monoterpene biological precursor of carvacrol and one of the main constituents of the essential oil from species of Protium, with more than 80% of these species found in the Amazon region (Siani et al, 1999). Recent studies have shown that species such as Protium heptaphyllum (Aubl.)…”

Section: Introductionmentioning

confidence: 99%

p-Cymene reduces orofacial nociceptive response in mice

Santana¹,

Quintans‐Júnior²,

Cavalcanti³

et al. 2011

Rev. bras. farmacogn.

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This study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized by the time in s that the mice remained rubbing the orofacial region, for a period of 40 min in the formalin test (first phase, 0-6 min; and second phase, 21-40 min), and for 42 and 15 min in the capsaicin and glutamate tests, respectively. To verify the possible opioid involvement in the antinociceptive effects, naloxone (i.p.) was administered into the mice 15 min prior to the pretreatment with p-cymene (100 mg/kg). Finally, whether or not the p-cymene evoked any change in motor performance in the Rota-rod test was evaluated. The results showed that the treatment with p-cymene, at all doses, reduced (p<0.001) the nociceptive behavior in all nociception tests. The antinociceptive effect of p-cymene was antagonized by naloxone (1.5 mg/kg). Additionally, mice treated with p-cymene did not show any change in motor performance. In conclusion, p-cymene attenuated orofacial nociception, suggesting an involvement of the opioid system in this effect. Thus, p-cymene might represent an important biomolecule for management and/or treatment of orofacial pain.

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“…Há ainda na literatura relatos sobre atividades antiinflamatória, antioxidante e inseticida de óleos essenciais [12,15,16,18,20]. propriedades do natural, principalmente no que se refere ao aroma [27].…”

Section: Dissertação -éRica Ap Souza Silva Usp/iqsc -Gqatpunclassified

"Estudo analítico dos óleos essenciais extraídos de resinas das espécies Protium spp"

Silva¹

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Evaluation of anti-inflammatory-related activity of essential oils from the leaves and resin of species of Protium

Cited by 138 publications

References 29 publications

Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae)

Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae)

p-Cymene reduces orofacial nociceptive response in mice

"Estudo analítico dos óleos essenciais extraídos de resinas das espécies Protium spp"

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