Evaluation of anti-inflammatory properties ofEurycoma longifoliaJack andEurycoma harmandianaPierrein vitrocultures and their constituents

Chaingam, Jiranan; Choonong, Rattanathorn; Juengwatanatrakul, Thaweesak; Kanchanapoom, Tripetch; Putalun, Waraporn; Yusakul, Gorawit

doi:10.1080/09540105.2022.2100324

Cited by 6 publications

(2 citation statements)

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“…57 Quassinoids and canthin-6-one alkaloids from EL and EH roots have been reported to exert anti-inflammatory effects via suppression of IL-6 levels and related inflammatory mediators. 58,59 This study demonstrates the efficacy of EL and EH roots, the herbs in Thai traditional medicine, on human coronaviruses, including SARS-CoV-2. In addition, EL and EH roots have potential benefits for long-COVID mitigation as well as anti-inflammatory and antiviral effects.…”

Section: Development Of Immunodetection Of Hcov-oc43 and Single-dose ...mentioning

confidence: 78%

“…Inflammatory markers, such as interleukin (IL)-6, tumor necrosis factor-α, and C-reactive protein, have been used as monitoring markers to evaluate the progression of severe COVID-19. , Herbal plants with anti-inflammatory effects might be useful for stabilizing the cytokine storm effect . Quassinoids and canthin-6-one alkaloids from EL and EH roots have been reported to exert anti-inflammatory effects via suppression of IL-6 levels and related inflammatory mediators. , This study demonstrates the efficacy of EL and EH roots, the herbs in Thai traditional medicine, on human coronaviruses, including SARS-CoV-2. In addition, EL and EH roots have potential benefits for long-COVID mitigation as well as anti-inflammatory and antiviral effects.…”

Section: Resultsmentioning

confidence: 99%

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Evaluating the in Vitro Efficacy of Quassinoids from Eurycoma longifolia and Eurycoma harmandiana against Common Cold Human Coronavirus OC43 and SARS-CoV-2 Using In-Cell Enzyme-Linked Immunosorbent Assay

et al. 2022

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Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, has become a pandemic and public health crisis. SARS-CoV-2 and the seasonal common cold coronavirus (HCoV-OC43) belong to the beta genus of human coronaviruses (HCoVs). In-cell ELISA assays were performed using HCoV-OC43 and SARS-CoV-2 and evaluated the antiviral activity of herbal plants. Eurycoma longifolia (EL) and Eurycoma harmandiana (EH) roots (antipyretic properties) and their constituent quassinoids, especially chaparrinone and eurycomalactone, showed potent anti-HCoV-OC43 and SARS-CoV-2 activities, and the low IC 50 values of the mentioned constituents were observed in the range of 0.32−0.51 μM. Eurycomanone and 13β,21-dihydroeurycomanone may contribute to the antiviral activity of EL, whereas chaparrinone is the major and active antiviral constituent of EH root. The content of quassinoids, β-carboline, and canthin-6-one alkaloids and the cytotoxicity profile of EL and EH extracts were varied regarding extraction solvents. The boiled water and 50% EtOH extractions of both plants were less toxic than those with 95% EtOH as the extraction solvent. Our research suggests that quassinoids, which come from EL and EH roots and are anti-coronavirus compounds, are potential treatment candidates for COVID-19 and merit further in vivo investigations.

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Section: Development Of Immunodetection Of Hcov-oc43 and Single-dose ...mentioning

confidence: 78%