Evaluation of anti-inflammatory potential of the leaves of Wendlandia heynei (Schult.) Santapau &amp; Merchant in Sprague Dawley rat

Maryam, Sonia; Khan, Muhammad Rashid; Shah, Sayed Afzal; Zahra, Zartash; Batool, Riffat; Zai, Jawaid Ahmed

doi:10.1016/j.jep.2019.111849

Cited by 8 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no direct evidence concerning the activity of rutin on TPA‐induced auricular edema, and it was only reported as one constituent of the active extracts and fractions from different plants [22] . Also, this flavonoid is accompanied by luteolin in several anti‐inflammatory plants of the Scorzonera genus [23] . Luteolin has shown that it, at 0.5 mg/ear in the same assay, exhibited an inhibition percentage of 86.9 %, with an ED50=0.25 mg/ear, [24] while isoquercetin was evaluated in a TPA‐induced edema assay as part of a mixture (at 0.5 mg kg −1 ) with hyperoside (quercetin‐3‐ O ‐galactoside).…”

Section: Resultsmentioning

confidence: 99%

Effect of Argemone mexicana on Local Edema and LPS‐Induced Neuroinflammation

Monterrosas-Brisson

Zagal-Guzmán

Zamilpa³

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

Argemone mexicana L. is a widely used plant in Mexican traditional medicine to treat inflammatory and nervous medical conditions. It has been subjected to several pharmacological and chemical studies in which acute anti‐inflammatory activity is indicated. This work aimed at finding an extract and fraction with anti‐inflammatory activity by means of 2‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced auricular edema. Afterward, the extract and the fraction were tested on neuroinflammation caused by lipopolysaccharides (LPS). Treatments obtained from A. mexicana included the methanolic extract (AmMeOH), a fraction extracted with ethyl acetate (AmAcOEt), and four sub‐fractions (AmF‐1 to AmF‐4), which were evaluated in auricular edema with the TPA assay. Both treatments with the most significant inhibitory effect were employed to test these in the LPS neuroinflammation model. AmAcOEt and AmF‐3 induced a higher inhibition of edema (%), and both diminished ear inflammation when viewed under a microscope. These treatments also raised an increase in spleen, but not in brain of mice with neuroinflammation. They were able to decrease the concentration of proinflammatory cytokines (TNF‐α, IL‐1β, and IL‐6) in both organs. Furthermore, the accumulation of amyloid‐β (Aβ) in hippocampus was not visible. AmF‐3 contains the flavonoids isoquercetin, luteolin, and rutin, the former being the most concentrated.

show abstract

Section: Resultsmentioning

confidence: 99%