Evaluation of Anti-inflammatory, Analgesic, and Antipyretic Activities of Pseuderanthemum palatiferum

Abstract

The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear edema, carrageenan-induced paw edema, arachidonic acid (AA)-induced paw edema, and cotton pellet-induced granuloma experiments. Acetic acid-induced writhing and tail-flick experiments were conducted to evaluate analgesic activity. Finally, antipyretic activity was evaluated in yeast-induced hyperthermia model. WEPP showed the anti-inflammatory activity and the analgesic activity but without antipyretic property. WEPP (2 mg/ear) significantly inhibited edema thickness induced by EPP (75%). Oral administration of WEPP (600 mg/kg) significantly inhibited paw edema induced by carrageenan (57%), and arachidonic acid (47%). WEPP (600 mg/kg) did not significantly reduce the transudative weight, granuloma weight, and alkaline phosphatase activity in cotton pellet-induced granuloma formation model. The anti-inflammatory property of WEPP demonstrated on the acute phase and not on the chronic phase of inflammation. WEPP oral administration (150, 300, and 600 mg/kg) significantly reduced the writhing response induced by acetic acid by 21%, 57%, and 79%, respectively. In tail-flick test, WEPP slightly increased the reaction time of rats (25%). The analgesic activity of WEPP may act via peripheral pathway. The antipyretic effect of WEPP (600 mg/kg) was not observed in yeast-induced hyperthermia model. WEPP displays an anti-inflammatory effect and has a prominent analgesic effect on the peripheral system.

Influence of Green Solvent Extraction on Phytochemicals, Potential Antidiabetic and In Vitro Anti-Inflammatory Activities of Pseuderanthemum palatiferum (Nees.) Radlk. Leaves

“…22 In an animal model, it was shown that oral administration of aqueous extract of the plant leaves (600 mg/kg) considerably suppressed paw edema induced by carrageenan and arachidonic acid. 4 Despite limited data about in vivo anti-inflammatory effects and human trials of the plant are available, the findings from these studies above altogether highlighted that P. palatiferum may be suitable for developing plantderived anti-inflammatory drugs.…”

“…For example, oral administration of fresh leaf aqueous extracts (0.6 g/kg) considerably suppressed paw edema induced by carrageenan (57%) and arachidonic acid (47%) in rats. 4 An oral glucose tolerance test in streptozotocin-nicotinamide-induced diabetic rats showed that leaf aqueous extract (0.25 g/kg and 0.50 g/kg) exerted hypoglycemic effects. 5 Leaf aqueous extracts also displayed anticancer activity by inhibiting cell viability and induce ROS-mediated mitochondrial related apoptosis in A549 cells.…”

Acute and Ninety-day Oral Toxicity of the Water Extract from the Fresh Leaves of Pseuderanthemum palatiferum in Rats

“…As the potential botanical applications to treat chronic diseases of the plant, however, the fresh leaf of P. palatiferum has been used. The water extract from the leaf of P. palatiferum reveals the hypotensive and bradycardic activities (Khonsung et al, 2011), anti-inflammatory and analgesic activities (Inchab et al, 2019), and gastroprotective activity (Inchab et al, 2018). This study aimed to assess acute and ninety-day oral toxicity of the water extract of the fresh leaf of P. palatiferum in rats because some signs and symptoms of toxicity may appear after repeated exposure.…”