Evaluation of anti - inflammatory activity of aqueous extract of leaves of hibiscus sabdariffa in albino rats

Abstract

Background: Inflammation continues to be an area of great interest for research, probably due to the non-availability of a safer and more effective analgesic and anti-inflammatory agent. This has led to increase in demand for natural products with anti-inflammatory activity having fewer side effects. Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are used in the treatment of inflammation, fever and pain. However, NSAIDs cause gastric damage as a major adverse reaction. In this study, the anti-inflammatory activity of aqueous extract H. sabdariffa Linn was studied using carrageenan and formalin for acute and chronic inflammation respectively in albino rats.Methods: In this study, anti-inflammatory activity of H. sabdariffa was studied and compared with standard drug, indomethacin. Aqueous extract of leaves of H. sabdariffa (200mg/kg or 400mg/kg) and indomethacin (25mg/kg) were used to separate groups of rats and paw edema was measured by plethysmometer and compared with control group.Results: H. sabdariffa did not show any significant reduction of paw edema (P >0.05) in both the models of inflammation i.e. carrageenan induced acute model and formalin induced chronic model of inflammation.Conclusions: H. sabdariffa didn’t show any significant anti-inflammatory activity.

Antioxidant and anti-inflammatory effects of Boswellia dalzielii and Hibiscus sabdariffa extracts in alloxan-induced diabetic rats

“…This effect is similar to that of glibenclamide, which has been proven to exhibit anti-inflammatory properties [ 54 , 55 ]. Our findings were also consistent with previous studies on the inflammatory benefits of B. dalzielii [ 15 , 45 ] and H. sabdariffa [ 43 , 53 ] in animal models of diabetes. These anti-inflammatory effects could be attributed to the presence of phytochemical compounds in both extracts, as demonstrated in our previous studies [ 13 , 14 ].…”

“…Inflammation, like oxidative stress, plays an important role in DM as hyperglycemia is always linked with the release of pro-inflammatory cytokines [ 50 , 51 ]. Inflammation is known to be a protective response of the host against infections and tissue damages, which can prevent the spread of pathogens or promote tissue repair [ 52 , 53 ]. NF-κB is a transcriptional factor that regulates inflammation and cytokine production, including TNF-α, IL-6, and IL-1β [ 52 ].…”

Pharmacological Activities of <i>Gongura</i> (Roselle) Leaf: Recent Advances

“…The aqueous extracts (leaves) of H. sabdariffa showed poor anti-inflammatory activity against albino rats in both the model (carrageenan-induced acute model and formalininduced chronic model) of inflammation 11 . The methanol extract of H. sabdariffa showed potent anti-inflammatory potential against carrageenan-induced inflammation compare to the standard 12 .…”

Anti-inflammatory activity and HPTLC phytochemical screening of Hibiscus sabdariffa leaves

“…Hence, there is a pressing need for safer effective alternative therapies. Herbal remedies represent such alternative and the leaves of H. sabdariffa constitute a promising candidate for anti-inflammatory evaluation (Apaza Ticona et al, 2022;Guddeti et al, 2015;Patil et al, 2017;Ramaevi et al, 2016;Zhen et al, 2016). The aim of this study is the evaluation of the antiinflammatory activity of the total ethanolic extract and different fractions of H. sabdariffa leaves collected in Egypt.…”