Evaluation of anti-diarrhoeal potential of ethanolic extract of Mimosa pudica leaves

Khalid, Mohammed Saifuddin; Shah, JineshKumar; Suresh, D. K.; Singh, RajnishKumar; Reddy, IV Narasimha; Kumar, Sunil

doi:10.4103/0973-8258.82096

Cited by 11 publications

(6 citation statements)

References 1 publication

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“…4,22 The plant composition such as steroids, tannins, flavonoids and phenolic compounds have been reported. 11,15 The plant constituent such as kaempferol and stigmasterol are known to improve insulin stimulating glucose uptake. [31][32][33] Although the major components that possess antidiabetic activity in the M. pudica extract were not precisely identified in this study.…”

Section: Effect Of Mpa and Mphe On Blood Cell Structurementioning

confidence: 99%

Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts

Konsue¹,

Picheansoonthon²,

Talubmook³

2017

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Section: Effect Of Mpa and Mphe On Blood Cell Structurementioning

confidence: 99%

Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts

Konsue¹,

Picheansoonthon²,

Talubmook³

2017

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“…35 The recipe, A. indicum and M. Pudica, the chemical components of the plants were revealed that any phytochemical of these composed with some antidiabetic substances including alkaloids, flavonoids, glycosides, saponins and tannins. 6,23,35 Saponins and alkaloids could be inhibit glucose uptake, while flavonoids could be protect various cell types from oxidative stressmediated cell injury. 36 The flavonoids such as kaempferol as well known chemical compound which improve insulin stimulating glucose uptake in mature 3T3L1 adipocytes and protect the body against free radicals, it is biologically plausible relation between flavonoids and low risk of diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…5 The most important biologically active constituents of this plants are alkaloids, steroids, tannins, flavonoids, glycosides and saponins compounds. 6 The wide range of pharmacological activities of this plant have been reported including wound healing, 7,8 analgesic, anti-inflammatory, 9 anticonvulsant, 10 anti-diarrhea, 6,11 anti-oxidant, 5,9,12,13 hepatoprotective, 13,14 hypolipidemic, 15,16 diuretic property, 17 hypoglycemic 5,[18][19][20] and hyperglycemia activities. 21 A. indicum Sweet is belonging to the family Malvaceae.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Konsue¹,

Talubmook²

2018

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Context:Abutilon indicum and Mimosa pudica were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. Aims: The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The recipe were composed of whole plants from A. indicum and M. Pudica (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. Results: All doses of the extracts were showed significantly (p<0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p<0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (p< 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p< 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. Conclusion: The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.

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“…Mimosa pudica L. is a medicinal plant of family Mimosaceae which is cosmopolitan in nature and contains phytochemicals such as alkaloids, steroids, terpenoids, tannins and flavonoids Bum et al, 2004;Dinda et al, 2006). The plant is traditionally promised to cure stomach disorders, haemorrhoids, respiratory troubles, fever, snake bites, anxiety, dysentery and inflammatory problems (Molina, Contreras, Tellez-Alcantara, 1999;Khalid et al, 2011). The seeds of M. pudica (MP) extrude glucuronoxylan hydrogel in water, which mainly consists of D-xylose and D-glucuronic acid (Muhammad et al, 2015;Saraswat, Pokharkar, 2012).…”

Section: Introductionmentioning

confidence: 99%

Appraisal of acute oral toxicity of glucuronoxylan hydrogel from Mimosa pudica seeds

Muhammad

Hussain

Ashraf

et al. 2018

Braz. J. Pharm. Sci.

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Glucuronoxylan hydrogel (GXH) isolated from M. pudica seeds was assessed for acute toxicology in albino mice that were alienated into four groups. Three groups, i.e., II, III and IV received GXH at a dose of 1, 2 and 5 g/kg, respectively while group I was retained untreated and provided routine diet. After administering GXH, mice were examined for vomiting, diarrhea, allergy and tremors for 8 h. All animals were carefully observed for food and water consumption at 1, 2, 3, 7 and 14 day after administering GXH. At the end of studies, blood samples were drawn for investigation of hematological and biochemical parameters. All animals were sacrificed, relative body weight of vital organs was calculated and their histopathology was studied. It was concluded that there was insignificant difference in body weight, behavioral pattern, food and water intake among treated and control groups. Haematology and biochemistry of blood samples from all groups were found analogous. Histopathological evaluation of vital body organs exhibited no lesions in all groups. Ocular, cardiac and dermal safety of GXH was also established on albino rabbits.

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Evaluation of anti-diarrhoeal potential of ethanolic extract of Mimosa pudica leaves

Cited by 11 publications

References 1 publication

Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts

Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Appraisal of acute oral toxicity of glucuronoxylan hydrogel from Mimosa pudica seeds

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