Evaluation of anti-depressant effect of lemon grass (&amp;lt;i&amp;gt;Cymbopogon citratus&amp;lt;/i&amp;gt;) in albino mice

Dudhgaonkar, Sujata; Mahajan, Manali Mangesh; Deshmukh, Swapnil Narayan; Admane, Pallavi; Khan, H. U.

doi:10.5455/2319-2003.ijbcp20140817

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…It contains several biologically active compounds with various pharmacological activities such as antibacterial, anti-diarrheal, anti-filarial, antifungal and anti-inflammatory properties [10][11][12][13][14][15]. Moreover, previous studies have shown that C. citratus is safe for human consumption, as no toxic effects have been observed over the years as caffeine free tea and herbal drink [16,17]. Recently, C. citratus was shown to exhibit antidepressant activity in the force swimming and tail suspension tests in mice [18].…”

Section: Discussionmentioning

confidence: 99%

Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice

et al. 2017

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Depression is a complex neuropsychiatric disorder, which affects the quality of life of the sufferers and treatment approach is associated with serious adverse effects and sometimes therapeutic failures. (CC) has been reported to exert anti-depressant effect but its mechanism of action is yet to be elucidated hence, the need for this study. The anti-depressant-like effect of aqueous leaf was evaluated using forced swim test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice. Interaction studies involving p-chlorophenylalanine (pCPA), an inhibitor of serotonin biosynthesis and yohimbine, α-adrenergic receptor antagonist were carried out to evaluate the role of monoaminergic system in the anti-depressant-like effect of CC. The effect of CC on spontaneous motor activity (SMA) was also assessed using activity cage. (25 and 50 mg/kg, p.o.) demonstrated antidepressant-like activity devoid of significant stimulation of the SMA in mice. However, the antidepressant-like property of CC was significantly (p<0.05) attenuated by pretreatment with yohimbine suggesting involvement of noradrenergic pathway in the action of the extract. Also, pCPA reversed the anti-immobility effect of CC, indicating the role of serotonergic system in the mediation of its antidepressant activity. Moreover, CC (25 and 50 mg/kg) potentiated the lethal effect of yohimbine in aggregated mice, which further suggest the involvement of monoaminergic systems in its action. The results of the study showed that might be interacting with serotonergic and noradrenergic pathways to mediate its anti-depressant-like effect in mice.

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Section: Discussionmentioning

confidence: 99%

Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice

et al. 2017

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“…It is characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, tiredness, and poor concentration (James et al, 2018). The advantages of herbal treatments would include its complementary nature to the conventional treatment, thus making the latter a safer and cheaper option for depressive disorders (Dudhgaonkar et al, 2014).…”

Section: Depressionmentioning

confidence: 99%

The Relationship between Aromatherapy and Mental Wellbeing: A Narrative Review

AL-mansour

2022

Unisia

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Mental disorders are patterns of behavioral or psychological symptoms that affect multiple areas of life; these disorders create distress for the person experiencing these symptoms. The search for the most effective and safe treatments is essential. Aromatherapy as a specialized segment of phyto-therapy have attracted the attention of many researchers as complementary method for treating patients with neurological and psychiatric complaint due to their low cost and ease of use. While, it could be practiced via inhalation or topical application and massage utilizing specific essential oils for several, minor, clinical uses as a natural way of healing a person’s mind, body and soul.

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“…The aqueous extract of C. citratus was dissolved in distilled water immediately before use. The doses of 25, 50 and 100 mg/ kg of C. citratus used in the study were selected based information obtained from literature [17].…”

Section: Preparation Of Plant Materialsmentioning

confidence: 99%

Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice

2017

IJNR

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Research Article IJNR (2017) 1:4 Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice Exposure to acute anoxic stress produces deleterious effects on the brain through the formation of oxidant molecules like reactive oxygen species. Thus, compounds with antioxidant property might demonstrate protective effect against the damaging effects of anoxic stress on brain cells. This study was carried out to evaluate the protective effect of Cymbopogon citratus, a medicinal plant with antioxidant property on convulsions induced by anoxic stress in mice. Male Swiss mice (20-22 g) were given C. citratus (25, 50 and 100 mg/kg, p.o), Panax ginseng (50 mg/kg, p.o) or vehicle (10 mL/kg p.o). Thirty minutes later, the animals were exposed to anoxic stress and the latency (s) to convulsion (anoxic tolerance time) was measured. Thereafter, the blood glucose level was measured using glucometer. The levels of malondialdehyde (MDA) and glutathione (GSH) were also determined in the brain homogenates of mice subjected to anoxic stress. C. citratus (25, 50 and 100 mg/kg, p.o) did not significantly (p > 0.05) delay the latency to anoxic convulsion and also failed to alter the brain concentrations of MDA and GSH in mice exposed to anoxic stress. However, C. citratus (25, 50 and 100 mg/kg, p.o) caused a significant and dose-dependent reduction in the blood glucose levels in anoxic stressed mice. These findings suggest that C. citratus has neither protective effect against convulsive episodes nor alter oxidative stress parameters induced by acute anoxic stress in mice. The decrease in blood glucose produced by C. citratus in anoxic condition may be unconnected with normalization of deregulation of plasma glucose level during stress responses.

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Evaluation of anti-depressant effect of lemon grass (<i>Cymbopogon citratus</i>) in albino mice

Cited by 8 publications

References 6 publications

Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice

Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice

The Relationship between Aromatherapy and Mental Wellbeing: A Narrative Review

Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice

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