Evaluation of anti-cancer properties of pegylated ethosomal paclitaxel on human melanoma cell line SKMEL- 3

Eskolaky, Elham Bagheri; Ardjmand, Mehdi; Akbarzadeh, Azim

doi:10.4314/tjpr.v14i8.14

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…The cytotoxicity of the nanoformulation was approximately 1.4 times that of the free drug. These results are consistent with the results obtained by Hoseineh et al and Eskolaky et al [18,22]. The results showed decreasing of IC 50 values of nanoformulations lead to enhance the cytotoxicity of nanoformulations.…”

Section: Discussionsupporting

confidence: 93%

“…In addition, the zeta potential of the drug-loaded nanoparticles was more positive than the empty nanoparticles. These results are consistent with the results obtained by Hoseineh et al and Eskolaky et al [18,22]. The results of the mean diameter of the nanoparticles using DLS after their fabrication confirmed the size of nanoparticles in the nano scale.…”

Section: Discussionsupporting

confidence: 93%

“…The physicochemical properties of nanoparticles can be influenced by experimental conditions of manufacturing such as concentration, temperature and sonication time [15,21]. The nanoparticles prepared under different conditions showed smaller sizes and a narrower size distribution profile [8,15,22].…”

Section: Discussionmentioning

confidence: 99%

“…MTT assay was used to assign cytotoxicity [1,18,22]. In this test, cells were cultured in colourless flat bottom 96-well-plate at density of 10 4 cells per well in 100 µL medium and incubated overnight.…”

Section: Evaluation Of In Vitro Cytotoxicitymentioning

confidence: 99%

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Cytotoxicity of Nanoliposomal Cisplatin Coated with Synthesized Methoxypolyethylene Glycol Propionaldehyde in Human Ovarian Cancer Cell Line A2780CP

Shirzad¹,

Jamehbozorgi²,

Akbarzadeh³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Of In Vitro Cytotoxicitymentioning

confidence: 99%

See 2 more Smart Citations

Cytotoxicity of Nanoliposomal Cisplatin Coated with Synthesized Methoxypolyethylene Glycol Propionaldehyde in Human Ovarian Cancer Cell Line A2780CP

Shirzad¹,

Jamehbozorgi²,

Akbarzadeh³

et al. 2016

Trop. J. Pharm Res

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“…The inhibiting etoposide is the topoisomerase II enzyme and inhibits the DNA production by affecting the pre-mitotic stage of cell division [7] that is why it is used to treat lung cancer. Like other chemotherapy drugs, taking this medication also has many side effects [8]. On the other hand, common chemotherapy drugs are distributed in the body passively, affecting cancer cells and others together.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and in vitro evaluation of PEGylated nanoliposomal containing etoposide on lung cancer

Kazemabadi

Heydarinasab

Akbarzadeh

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Introduction and objective: Lung cancer is the most common one in terms of outbreak and mortality. Since most modern treatments have many side effects, finding an effective and alternative therapy seems necessary. The present study aimed to determine the effect of PEGylated liposomal etoposide nanoparticles on the lung cancer (A-549 and Calu6 cell lines). Materials and methods: The PEGylated liposomal etoposide nanoparticles were prepared by reversephase evaporation method. The particle size and zeta potential of the nanoparticles were measured by Zetasizer. The nanoparticle cytotoxicity was examined by MTT method. The vesicular drug release pattern was examined by dialysis method. The amount of loaded drug and the encapsulation efficiency (EE) was also measured and calculated. Apoptosis test was performed using flow cytometry with Annexin V kit. Results: The mean particle size, size distribution, and zeta potential of PEGylated liposomal etoposide nanoparticles were 122.5 ± 4.8 nm, 0.252 ± 0.12 and À13.7 ± 0.51 mv, respectively. The etoposide release in prepared formulations was detected to be about 15.64% after 50 hr. The cytotoxic effect of etoposide nanoparticles on lung cancer A-549 and Calu6 cell lines showed more anti-tumour activity compared to the free drug used. Conclusion:The results showed that the PEGylated liposomal nanoparticles were used as a suitable nanocarrier for etoposide injection. It was also found that the drug effect on the nanodrug formulations was higher than that of the free drug.

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Vesicular Nanosystem as a Promising Platform for the Management of Cancer

Kamel,

Darwish,

Youness

et al. 2024

Interdisciplinary Cancer Research

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Evaluation of anti-cancer properties of pegylated ethosomal paclitaxel on human melanoma cell line SKMEL- 3

Cited by 15 publications

References 16 publications

Cytotoxicity of Nanoliposomal Cisplatin Coated with Synthesized Methoxypolyethylene Glycol Propionaldehyde in Human Ovarian Cancer Cell Line A2780CP

Cytotoxicity of Nanoliposomal Cisplatin Coated with Synthesized Methoxypolyethylene Glycol Propionaldehyde in Human Ovarian Cancer Cell Line A2780CP

Preparation, characterization and in vitro evaluation of PEGylated nanoliposomal containing etoposide on lung cancer

Vesicular Nanosystem as a Promising Platform for the Management of Cancer

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