Evaluation of anti–bacterial and anti–oxidant potential of andrographolide and echiodinin isolated from callus culture of Andrographis paniculata Nees

Abstract

This preliminary study showed promising anti-bacterial activity and moderate free radical scavenging activity of AND and ECH, and it may provide the scientific rationale for its popular folklore medicines.

In-VivoEffect of Andrographolide on Alveolar Bone Resorption Induced byPorphyromonas gingivalisand Its Relation with Antioxidant Enzymes

“…AND has been used for many years to treat a variety of diseases including bacterial and viral infections. A previous study by Arifullah et al [27] showed that AND has antibacterial activities. Earlier studies did not show significant toxicity of AND through clinical and histopathology observations [28].…”

Intramolecular Methionine Residue and Its Peptide Segments Stabilize Dehydroandrographolide Succinate-Methoxypolyethylene Glycol Conjugates

“…Recent pharmacological studies have shown that andrographolide and its derivatives have antibacterial, 1 anti-inflammatory, 2 antiviral, 3 anticancer, 4 anti-HIV, 5 liver-protecting, 6 and antioxidant activities. Recent pharmacological studies have shown that andrographolide and its derivatives have antibacterial, 1 anti-inflammatory, 2 antiviral, 3 anticancer, 4 anti-HIV, 5 liver-protecting, 6 and antioxidant activities.…”

“…A total of 5.68 g of pure product was obtained as a white solid in 45.2% yield 1. The reaction was complete after 8 h. The mixture was concentrated, applied to a silica gel column, and eluted with a solution of MeOH in DCM (MeOH:DCM = 1:30).…”

“…11 mmol) and DMAP (0.061 g, 0.5 mmol) were added. 2 was made according to the methods described for 1 in 39.5% yield 1. A total of 5.68 g of pure product was obtained as a white solid in 45.2% yield 1.…”

“…The reaction was complete after 8 h. The mixture was concentrated, applied to a silica gel column, and eluted with a solution of MeOH in DCM (MeOH:DCM = 1:30). A total of 0.66 g of 4 was obtained in 34.4% yield, with a purity of 97.5% according to HPLC analysis 1. H NMR (400 MHz, CDCl3) δ7.18 (s, 1H), 6.91 (m, 1H), 6.13 (d, J = 15.6 Hz, 1H), 4.82 (s, 2H), 4.80 (s, 1H), 4.63 (m, 1H), 4.56 (s, 1H), 4.25 (m, 6H), 3.4-3.9 (m, 198H), 3.38 (s, 6H), 2.66 (m, 8H), 2.45 (d, J = 12.1 Hz, 1H), 2.34 (d, J = 10.0 Hz, 1H), 2.03 (m, 1H), 1.85 (d, J = 12.1 Hz, 1H), 1.68 (m, 2H), 1.55 (m, 2H), 1.27 (m, 2H), 1.02 (s, 3H), 0.88 ppm (s, 3H).…”