Evaluation of Anterior Segment Parameters in Patients with Neurofibromatosis Type 1

Duru, Necati; Göktaş, Emre; Özköse, Ayşe; Duru, Zeynep; Altunel, Orhan; Ataş, Mustafa; Özlü, Emin

doi:10.5301/ejo.5000756

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…In vitro study of the corneal endothelium of NF1 patients post mortem would be a difficult and longstanding project, given the rarity of the studied disease, but also a very ambitious idea concerning the therapeutic management of patients in need for transplant because of endothelial dystrophy or endothelial damage post-surgery or trauma. Finally, as far as CCT is concerned, there was no statistically significant difference between NF1 patients and controls in our study ( P = 0.935), which is in accordance with the findings of the study conducted by Duru et al [ 31 ] in 17 NF1 patients and 17 age- and gender-matched healthy individuals ( P = 0.875).…”

Section: Discussionsupporting

confidence: 92%

Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1

Florou

Aissopou

Chalkiadaki

et al. 2021

Indian J Ophthalmol

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Purpose: The aim of this study was to evaluate the morphological properties of corneal endothelial cells and central corneal thickness (CCT) in patients with neurofibromatosis type 1 (NF1) and to compare them with age-matched healthy controls. Methods: Nineteen NF1 patients and 38 healthy individuals were recruited. All participants underwent complete ophthalmological examination as well as noncontact specular microscopy to measure endothelial cell density (ECD), average cell area (AVG), coefficient of variation of cell area (CV), the percentage of hexagonal cells, and CCT. Eyes with previous ocular trauma, inflammation or surgery, and preexisting corneal and ocular surface diseases were excluded. Results: NF1 patients had higher ECD compared to healthy controls of the same age (2764.2 ± 270.4 versus 2570.4 ± 449.2 cells/mm, respectively), although at a borderline level ( P = 0.051). Patients with NF1 presented significantly lower CV and AVG when compared to controls (32.9 ± 4.6 versus 37.8 ± 9.5%, P = 0.011 and 364.9 ± 34.4 versus 406.0 ± 107.4 µm, P = 0.038, respectively). The NF1 group had significantly higher hexagonality in comparison with controls (55.7 ± 6.5 versus 50.5 ± 9.9%, P = 0.025). CCT was similar between the two groups ( P = 0.955). Conclusion: Our results show that corneal endothelium has more favorable morphological characteristics in NF1 patients compared to healthy individuals of the same age.

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Section: Discussionsupporting

confidence: 92%

Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1

Florou

Aissopou

Chalkiadaki

et al. 2021

Indian J Ophthalmol

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“…However, many other ocular manifestations are reported in the literature although they are not considered diagnostic for NF1. 4 Among these, an increased prevalence of ametropia, especially myopia, [10][11][12] and astigmatism 12,14 and anterior segment parameters 13 changes has been reported as associated with NF1.…”

Section: Discussionmentioning

confidence: 99%

“…14 However, while patients younger than16 years old and patients below 30 years of age with manifest hypermetropia were assigned to cycloplegic autorefraction with cyclopentolate, patients with an age more than 16 years old were assigned to autorefraction without cycloplegia. 14 Duru et al 13 revealed that NF1 was associated with a reduction in ACD, irido-corneal angle, and anterior change volume evaluated by Pentacam Sheimpflug camera, that may represent a risk for a development of acute angle-closure glaucoma. Authors supposed these changes are due to proliferation of melanocytes, Schwann cells and fibroblasts on the iris surface.…”

Section: Discussionmentioning

confidence: 99%

“…4 The most typical example is represented by choroidal abnormalities, which are advocate as a new diagnostic criteria for NF1. [5][6][7][8][9] Myopia [10][11][12] and anterior segment parameters changes such as alterations in anterior chamber depth, iridocorneal angle, anterior chamber volume, and pupil size 13 have been reported as additional feature of NF1.…”

Section: Introductionmentioning

confidence: 99%

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Biometric and refractive errors evaluation in patients with neurofibromatosis type 1

Vagge

Corazza

Vagge

et al. 2020

European Journal of Ophthalmology

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Purpose: To analyze biometric changes and prevalence of refractive in patients with neurofibromatosis type 1 (NF1). Methods: Retrospective, case-controlled study involving patients affected by NF1 and healthy control subjects. Data on biometric measurements such as axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), keratometry (K1 and K2) values, and white-to-white (WTW), obtained by use of optical low-coherence reflectometry on a Lenstar LS 900® (Haag-Streit AG, Switzerland) were collected and analyzed. Cycloplegic refractions were then performed. Results: Overall, 166 eyes of 83 patients diagnosed with NF1 (mean age 21.6 ± 9.8) were enrolled and compared with 178 eyes of age-matched healthy subjects (mean age 22.6 ± 6.6). One hundred sixty-six (22.8%) and 33 of 178 (18.5%) eyes were myopic in NF1 patients and healthy subjects, respectively. The prevalence of hyperopia in the NF1 group was 12 of 166 (7.2%) whereas in the healthy control group was 14 of 178 (8.9%). Twenty-nine of 166 (17.4%) and 34 of 178 (19.1%) eyes presented astigmatism in NF1 and control group, respectively. These differences were not statistically significant ( p-values > 0.05). Refractive errors such as myopia, hyperopia, and astigmatism were similar between the two groups. The difference of AL, CCT, ACD, LT, K values, and WTW were no statistically significant between the two groups ( p-values > 0.05). Conclusion: Refractive errors and ocular biometric parameter seem not to be an addition findings of NF1.

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Using Anterior Segment Optical Coherence Tomography to Assess Angle Anatomy in Patients with Neurofibromatosis Type 1

Duru¹,

Altunel²

2020

Optom Vis Sci

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SIGNIFICANCE Lisch nodules have been identified in more than 90% of patients 16 years or older with neurofibromatosis type 1 (NF1). According to our hypothesis, the presence of Lisch nodules in patients with NF1 might affect the anterior chamber angle (ACA) parameters. PURPOSE The aim of this study was to evaluate the anterior segment angle parameters using anterior segment optical coherence tomography in patients with NF1. METHODS A total of 42 eyes from 21 patients with NF1 (study group) and 42 eyes from 21 age- and sex-matched healthy individuals (control group) were included in this study. Angle opening distance at 500 (AOD500) and 750 μm (AOD750) anterior to the scleral spur, ACA, and iris thickness (IT) values were measured in the temporal (T) and nasal (N) quadrants using anterior segment optical coherence tomography. RESULTS The mean AOD500 and AOD750 values in both quadrants were significantly lower in the study group compared with the control group (T-AOD500: 548 ± 151 vs. 761 ± 288 [P < .001], T-AOD750: 705 ± 175 vs. 921 ± 334 [P < .001], N-AOD500: 599 ± 223 vs. 777 ± 292 [P = .002], and N-AOD750: 756 ± 268 vs. 948 ± 303 [P = .003], respectively). The mean ACA values in both quadrants were significantly narrower in the study group compared with the control group (T-ACA: 29.52 ± 6.36 vs. 40.83 ± 8.90 [P < .001] and N-ACA: 30.05 ± 7.11 vs. 41.29 ± 8.68 [P < .001], respectively). The IT values in both quadrants were significantly thicker compared with the control group (T-IT500: 406 ± 78 vs. 355 ± 59 [P = .001], T-IT750: 453 ± 103 vs. 362 ± 100 [P < .001], N-IT500: 416 ± 93 vs. 353 ± 54 [P < .001], and N-IT750: 437 ± 91 vs. 370 ± 95 [P = .002], respectively). CONCLUSIONS We have revealed lower angle opening distance values in individuals with NF1 than in the healthy ones, as well as significantly narrower ACA values and significantly thicker IT values.

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Evaluation of Anterior Segment Parameters in Patients with Neurofibromatosis Type 1

Abstract: Our results reveal that NF1 is associated with statistically signiﬁcant alterations in anterior chamber depth, iridocorneal angle, anterior chamber volume, and pupil size in patients with NF1 when compared with healthy controls.

Cited by 3 publications

References 15 publications

Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1

Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1

Biometric and refractive errors evaluation in patients with neurofibromatosis type 1

Using Anterior Segment Optical Coherence Tomography to Assess Angle Anatomy in Patients with Neurofibromatosis Type 1

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