Evaluation of angiogenesis and perfusion of bone marrow lesions: Role of semiquantitative and quantitative dynamic MRI

Hawighorst, H.; Libicher, M.; Knopp, Michael V.; Michel, Thomas; Kauffmann, G. W.; Kaick, G. van

doi:10.1002/(sici)1522-2586(199909)10:3<286::aid-jmri9>3.0.co;2-n

Cited by 94 publications

(46 citation statements)

References 34 publications

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“…Amplitude A that was previously shown to correlate with blood vessel density is significantly increased in Group B "focal" vs. Group A "diffuse." 17,22 This finding suggests that the ability to induce a maximum density of blood vessels in the bone marrow might be a separate and distinct feature in this subgroup of MM patients (Group B "focal"). The 8 bone marrow biopsies available in our study were not sufficient for a formal analysis of correlation between immunohistochemically detected microvessel density and dMRI.…”

Section: Discussionmentioning

confidence: 96%

“…1). 17,22 Bone marrow biopsies were performed at the spina iliaca superior posterior on the right pelvis in 8 cases for staging purposes. Therefore this site was included in the imaging procedure for later comparison of histologic and imaging results.…”

Section: Computation Of Pharmacokinetic Parameters From Dynamic Mr Immentioning

confidence: 99%

“…15,16 The application of this method in various diseases of the bone marrow was recently reported. 17,18 The aim of our study was to perform a microcirculation analysis of bone and bone marrow of lumbar spine and right spina iliaca posterior superior in patients with MM using dMRI. Quantitative parameters A and k 21 in MM were compared with normal controls.…”

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confidence: 99%

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Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging

et al. 2001

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The aim of our study was to investigate the quantitative microcirculation parameters amplitude A (hypothetical intravascular volume) and exchange rate constant k 21 (hypothetical vascular permeability) by contrast-enhanced dynamic magnetic resonance imaging (dMRI) as markers of angiogenesis in multiple myeloma (MM). Therefore lumbar spine and spina iliaca superior posterior of 16 normal controls and 41 patients with active MM were assessed using a dMRI protocol with a pump controlled bolus infusion of Gadolinium-DTPA. Pharmacokinetic parameters, amplitude A and exchange rate constant k 21 were calculated according to a 2-compartment model. Color-coded parameter images were generated from pharmacokinetic data analysis and superimposed onto the conventional MR images.

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Section: Discussionmentioning

confidence: 96%

Section: Computation Of Pharmacokinetic Parameters From Dynamic Mr Immentioning

confidence: 99%

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Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging

et al. 2001

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“…Degenerative endplate marrow changes showed significantly diminished contrast inflow and outflow rate, but significantly higher and delayed contrast enhancement compared to normal marrow. Considering reported data on contrast kinetics, reduced and delayed inflow may reflect diminished vascularization or blood flow (18)(19)(20)(21)(22). Increased but delayed maximum enhancement and decreased outflow may result from altered capillary permeability and surface area or increased EES volume (18)(19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Degenerative endplate changes of the lumbosacral spine: Dynamic contrast‐enhanced MRI profiles related to age, sex, and spinal level

Savvopoulou

Maris²,

Κουρέας

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate differences in perfusion profiles between degenerative endplate marrow changes and normal vertebral marrow in relation to spinal level, age, and sex with dynamic contrast-enhanced magnetic resonance imaging (DCE MRI).Materials and Methods: Ninety-two consecutive patients referred for evaluation of low back pain or sciatica, without history of malignant or chronic disease, underwent conventional and DCE MRI of the lumbosacral spine. Fifty-two of them demonstrated degenerative endplate marrow changes. Regions of interest were placed on sites of normal marrow (group A) and degenerative changes (group B) on subtracted images. Fitted time-intensity curves (fTICs) were generated and evaluated for curve pattern. Both groups were stratified into upper (L1-L2) and lower (L3-I1) levels, males and females younger or older than 50 years. Perfusion parameters were calculated and statistically compared for both groups and subgroups. Receiver operator curve (ROC) analysis was also performed.Results: Two fTIC patterns were identified. Perfusion parameters of degenerative changes and normal marrow differed significantly, even when groups were stratified for spinal level, age, and sex (P < 0.05). A time to peak value >108 seconds was characteristic for degenerative changes with sensitivity 69.5% and specificity 84.6%.Conclusion: DCE MRI profiles of degenerative endplate marrow changes of the lumbosacral spine differ significantly from normal marrow regardless of spinal level, age, or sex.

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“…These changes in signal intensity are recorded by serial images acquired before, during, and after the injection. Relative changes in semiquantitative parameters, such as the maximum gradient of the signalintensity-time curve, the maximum increase in signal intensity normalized to baseline signal intensity (enhancement), and the area under the initial part of the curve, can be examined and are indirectly related to changes in the physiologic end points of interest: tissue perfusion, vascular permeability, and vessel surface area [27,30,[35][36][37]. A couple of reproducibility studies of this technique in humans have been performed, in glioma and in liver tumors, which defined the limits of change in these DCE-MRI parameters that might occur spontaneously between two examinations performed 5 days apart [38][39][40].…”

Section: Su11248mentioning

confidence: 99%

Molecular Imaging of Antiangiogenic Agents

2005

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Many novel antiangiogenic agents are currently in various phases of clinical testing. These agents tend to be cytostatic, and therefore few responses are observed with conventional imaging by computerized tomography. Furthermore, toxicity with these agents is seen when the maximum-tolerated dose is combined with chemotherapy. Hence, there is a need to develop imaging strategies that can determine the minimum and optimum biologically active doses.There is increasing awareness of the need to obtain evidence of drug activity through the use of surrogate markers of the biologic mechanism of action during early clinical trials, in addition to determining the pharmacokinetics, toxicity profile, and maximum-tolerated dose. One of the major impediments to the rapid development of antiangiogenic agents in the past has been the lack of validated assays capable of measuring an antiangiogenic effect directly in patients. Recently, dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) has LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Explain the rationale for targeting angiogenesis and for combining antiangiogenic agents with other chemotherapeutic agents.2. Name the various techniques that are available for the assessment of the antiangiogenic activity of drugs and their current limitations.3. Identify the role of DCE-MRI in imaging antiangiogenics.Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com CME CME

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Evaluation of angiogenesis and perfusion of bone marrow lesions: Role of semiquantitative and quantitative dynamic MRI

Cited by 94 publications

References 34 publications

Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging

Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging

Degenerative endplate changes of the lumbosacral spine: Dynamic contrast‐enhanced MRI profiles related to age, sex, and spinal level

Molecular Imaging of Antiangiogenic Agents

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