Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device

Nam, Soonkeon; Choi, Samjin; Cheong, Youjin; Kim, Yeon-Hee; Park, Hun-Kuk

doi:10.1016/j.jbiomech.2014.11.018

Cited by 28 publications

(25 citation statements)

References 16 publications

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“…7 Others have recreated vessel geometries characteristic of stenosed vessels 8 and even entire vascular networks such as the circle of Willis. 9 Importantly, these models are often in close agreement with conclusions drawn from analogous animal models. Physiologically inspired geometries, when combined with the appropriate chemical and mechanical cues, can recreate microenvironments with clinically relevant results, for example, in the production of platelets from stem cell-derived megakaryocytes.…”

supporting

confidence: 58%

Physiochemical artifacts in FeCl3 thrombosis models

Neeves

2015

Blood

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supporting

confidence: 58%

Physiochemical artifacts in FeCl3 thrombosis models

Neeves

2015

Blood

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“…Hence, anatomical variation in the circle of Willis such as hypoplasia or absence of an arterial segment would affect hemodynamic parameters, which may lead to cerebrovascular disease. Indeed, abnormal circle of Willis has been associated with high risk of IA development and rupture, which may be the resultant of abnormal WSS . As approximately 40% of the population has an incomplete circle of Willis, it suggests that even if hemodynamic factors are key players in IA development, other additive factors might be required …”

Section: Localization Of Iasmentioning

confidence: 99%

Role of hemodynamics in initiation/growth of intracranial aneurysms

Diagbouga

Morel

Bijlenga

et al. 2018

Eur J Clin Investigation

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Background: Intracranial aneurysm (IA) is a disease of the vascular wall resulting in abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of 2%-3% in the adult population. IAs are mostly small, quiescent and asymptomatic; yet, upon rupture, severe brain damage or even death is frequently encountered. In addition to clinical factors, hemodynamic forces, mainly wall shear stress (WSS), have been associated with the initiation of IAs and possibly with their risk of rupture. However, the mechanism by which WSS contributes to aneurysm growth and rupture is not completely understood. Design: PubMed and Ovid MEDLINE databases were searched. In addition, key review articles were screened for relevant original publications. Results: Current knowledge about the relation between WSS and IA has been obtained from both computational fluid dynamic studies in patients and experimental models of IA formation and growth. It is increasingly recognized that a high wall shear stress (gradient) participates to IA formation and that both low and high WSS can drive IA growth. Primary cilia (PC) play an important role as mechanosensors as patients with polycystic kidney disease, which is characterized by the absence or dysfunction of PC, have increased risk to develop IAs as well as increased risk of rupture. Conclusion: Wall shear stress is a key player in IA initiation and progression. It is involved in vascular wall remodelling and inflammation, processes underlying aneurysm pathophysiology. K E Y W O R D Sendothelium, intracranial aneurysms, primary cilium, wall shear stress

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“…The aim of this study was also to examine whether anatomical variations of MCA and the circle of Willis have impact on formation of MCA aneurysms. It has been proved on theoretical models that changes in the circle of Willis lead to increased shear stress in MCA [13]. It is also known, that shear stress is one of the most important factors influencing aneurysm formation.…”

Section: Mca Aneurysmsmentioning

confidence: 99%

“…Anatomical variations of the circle of Willis are caused by its arrested development. Underdeveloped arteries are weakened and at higher risk of aneurysms formation [13]. The anatomical variations can also lead to increased shear stress in connected arteries.…”

Section: Introductionmentioning

confidence: 99%