Evaluation of Analgesic Effect of Caudal Epidural Tramadol, Tramadol-Lidocaine, and Lidocaine in Water Buffalo Calves (<i>Bubalus bubalis</i>)

Atiba, Ayman; Ghazy, Alaa; Gomaa, Naglaa; Kamal, Tarek; Shukry, Mustafa

doi:10.1155/2015/575101

Cited by 7 publications

(10 citation statements)

References 13 publications

(30 reference statements)

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“…The duration of action is short which is not suitable in long-duration surgical operations making readministration necessary to complete long surgical procedures [1,3]. Opioids and alpha-2 adrenergic agonists are commonly used in combinations with lidocaine resulting in longer and adequate analgesia [1,3,6-11]. …”

Section: Lidocainementioning

confidence: 99%

“…The dose ranged between 0.11 and 0.22 mg/kg of 2% solution [6,9,11]. Most adult cows required between 5 and 6 ml of the drug to achieve adequate surgical analgesia of the caudal regions of the body.…”

Section: Lidocainementioning

confidence: 99%

“…Tramadol has not been tested alone in any of the animal species as an analgesic agent, however, lidocaine in combination with tramadol (LT) has been used in camel calves and in adult Holstein cows and in buffalo calves [8,10,11]. LT in camel and buffalo calves produced complete analgesia in the tail, anus, and perineum in addition to a mild to moderate sedation [10,11].…”

Section: Tramadolmentioning

confidence: 99%

“…LT in camel and buffalo calves produced complete analgesia in the tail, anus, and perineum in addition to a mild to moderate sedation [10,11]. However, animals that received LT experienced much more ataxia than those that received lidocaine alone.…”

Section: Tramadolmentioning

confidence: 99%

“…In another study, the duration of analgesia produced by tramadol-lidocaine combination was significantly longer than lidocaine alone. Ataxia was mildly observed in LT and was moderate in lidocaine [11]. …”

Section: Tramadolmentioning

confidence: 99%

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Epidural analgesia in cattle, buffalo, and camels

Ismail¹

2016

Vet World

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Epidural analgesia is commonly used in large animals. It is an easy, cheap, and effective technique used to prevent or control pain during surgeries involving the tail, anus, vulva, perineum, caudal udder, scrotum, and upper hind limbs. The objectives of this article were to comprehensively review and summarize all scientific data available in the literature on new techniques and drugs or drug combinations used for epidural anesthesia in cattle, camel, and buffalo. Only articles published between 2006 and 2016 were included in the review. The most common sites for epidural administration in cattle, camels, and buffalos were the sacrococcygeal intervertebral space (S5-Co1) and first intercoccygeal intervertebral space (Co1-Co2). The most frequently used drugs and dosages were lidocaine (0.22-0.5 mg/kg), bupivacaine (0.125 mg/kg), ropivacaine (0.11 mg/kg), xylazine (0.05 mg/kg), medetomidine (15 µg/kg), romifidine (30-50 µg/kg), ketamine (0.3-2.5 mg/kg), tramadol (1 mg/kg), and neostigmine (10 µg/kg), and the clinical applications, clinical effects, recommendations, and side effects were discussed.

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Section: Lidocainementioning

confidence: 99%

Section: Lidocainementioning

confidence: 99%

Section: Tramadolmentioning

confidence: 99%

Section: Tramadolmentioning

confidence: 99%

Section: Tramadolmentioning

confidence: 99%

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Epidural analgesia in cattle, buffalo, and camels

Ismail¹

2016

Vet World

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Lumbosacral injection of lidocaine, detomidine and lidocaine–detomidine in goats: anti-nociceptive effects and changes on haematobiochemical parameters

Zayed

Mahmoud

Khalil

et al. 2020

Journal of Applied Animal Research

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2020) Lumbosacral injection of lidocaine, detomidine and lidocaine-detomidine in goats: anti-nociceptive effects and changes ABSTRACT This study was carried out to compare the analgesic effects and haematobiochemical changes produced by the administration of lidocaine, detomidine and lidocaine-detomidine combination in the epidural space of goats. All goats were assigned to all of the three different epidural treatments using a balanced crossover design with two-weeks washout period. Nociception was investigated by pinprick; times to the onset and duration of anti-nociception in the perineal region were demonstrated. Incoordination, ataxia and analgesic effects were carefully observed and recorded according to the scoring system. The blood samples for haematological and biochemical changes were collected at 0, 30, 60, 90 and 120 min post-treatment. Our results showed that detomidine treatment produced a highly significant (P < 0.01) and (P < 0.0001) earlier onset time than lidocaine and lidocaine-detomidine combination, respectively. Detomidine treatment had a significantly longer duration of analgesia than lidocaine (P < 0.01) and lidocaine-detomidine combination (P < 0.0001) treatments. Moreover, all treatments showed no effect on haematological or biochemical parameters, with no obvious systemic effects. In conclusion, administering a detomidine provided a longer duration of analgesia and a useful level of systemic sedation in goats. ARTICLE HISTORY

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Antinociceptive effect of lidocaine, tramadol, and their combination for lumbosacral epidural analgesia in rabbits undergoing experimental knee surgery

et al. 2022

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Aim The current study aimed to evaluate the antinociceptive effect of lidocaine, tramadol, and their combination for lumbosacral epidural analgesia in rabbits undergoing knee surgery. Materials and methods This study was performed on 24 male New Zealand white rabbits weighing 2.8 to 3.0 kg and was allocated into three groups. All groups were anaesthetized by intramuscular (IM) injection of 35 mg/kg ketamine and 5 mg/kg xylazine, 0.1 mg/kg butorphanol. Rabbits in Group A received epidural analgesia of 4 mg/kg lidocaine 2%; Group B rabbits received epidural analgesia of 4 mg/kg tramadol 5%, and Group C rabbits received epidural analgesia of a combination of 4 mg/kg lidocaine and 4 mg/kg tramadol. Prior to and during surgery, the following parameters were recorded in a regular pre-set time interval: onset time of analgesia (OT), duration of flaccid paralysis (DFP), duration of analgesia (DA), onset and duration of sensory blockade, onset and duration of motor blockade, heart rate (HR), respiratory rate (RR), and rectal temperature (RT). Results The mean OT demonstrated a significant decrease (P < 0.05) in Group C (46.5 ± 1.4 sec) compared to Group A and B (61.0 ± 2.4 and 54.5 ± 3.5 sec), respectively. DFP was significantly lower (P < 0.05) in Group C (35.5 ± 2.9 min) than in Group A and B (17.6 ± 1.4 and 21.8 ± 3.6), respectively. DA showed a significant increase (P < 0.05) in group C (45.8 ± 3.3 min) compared to groups A and B, respectively (23.3 ± 1.1 and 31.5 ± 2.3). Heart rate, RR, and RT significantly decreased in Group C compared to the other groups. Conclusion According to the current study findings, lumbosacral epidural administration of lidocaine combined with tramadol could be a better choice for potentiating the analgesia than administration of either drug separately and may be safely used in rabbits undergoing knee surgery.

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Evaluation of Analgesic Effect of Caudal Epidural Tramadol, Tramadol-Lidocaine, and Lidocaine in Water Buffalo Calves (Bubalus bubalis)

Cited by 7 publications

References 13 publications

Epidural analgesia in cattle, buffalo, and camels

Epidural analgesia in cattle, buffalo, and camels

Lumbosacral injection of lidocaine, detomidine and lidocaine–detomidine in goats: anti-nociceptive effects and changes on haematobiochemical parameters

Antinociceptive effect of lidocaine, tramadol, and their combination for lumbosacral epidural analgesia in rabbits undergoing experimental knee surgery

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