Evaluation of analgesic, anti-inflammatory, and antipyretic activity of piperine: An experimental study

Dhargawe, Nikhil; Mahakalkar, Sunil M; Mohod, Bhagyashree; Raj, Jeffrey Pradeep

doi:10.4103/pr.pr_94_19

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…Since the pattern of action of the aqueous extract of C. febrifuga is somewhat similar to that of morphine and pentazocine which are well known central and peripheral analgesic respectively, the plant leaf aqueous extract probably has bioactive constituents that are responsible for the perceived biphasic pain alleviation. Also noted was dose dependent action of the plant leaf extract which invariably was in line with those reported by Sabina et al (2013) and Nikhil et al (2020).…”

Section: Effect Of Aqueous Extract Of Crossopteryx Febrifuga On Hot P...supporting

confidence: 90%

Antinociceptive Properties of Leaf Aqueous Extract of Crossopteryx Febrifuga (Afzel. Ex G. Don) Benth

Isah¹,

Idu²,

Amaechina³

2022

FJS

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Nociceptive pain is a sensational discomfort that is usually associated with injury or illness found affecting the body either internally or externally. Crossopteryx febrifuga is one of the medicinal plants which are locally used in the management of pain especially in the North Central Region of Nigeria. Many conventional drugs which are being applied in managing pain aside being not affordable and readily accessible by the majority of people at rural areas have one side effect or the other. Therefore, this research was conducted to evaluate the potentiality of aqueous extract of C. febrifuga in alleviating pain in Wistar rats. The study was carried out using acetic acid induced writhing and Edson hot plate methods. On acetic acid induced pain, the aqueous extract at 50 and 100 mg/kg inhibited pain significantly by reducing the number of writhing by average of 3.9 per minute while at 200 mg/kg, the extract reduced pain by reducing the number of writhing by average of 4.2 per minute. Similarly, the extract at all doses administered in hot plate induced method inhibited pain by increasing the time the rats took to jump off the hot plate. The data obtained from the analgesic study of C. febrifuga aqueous extract suggests that it has anti-nociceptive property as evident in both models. This, therefore revealed that the plant leaf aqueous extract possessed both the peripherally and centrally mediated analgesic properties. For this reason, the plant leaf could be a potential antinociceptive agent if subjected to clinical trial and proved

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Section: Effect Of Aqueous Extract Of Crossopteryx Febrifuga On Hot P...supporting

confidence: 90%

Antinociceptive Properties of Leaf Aqueous Extract of Crossopteryx Febrifuga (Afzel. Ex G. Don) Benth

Isah¹,

Idu²,

Amaechina³

2022

FJS

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“…Piperine exhibits a range of pharmacological effects, including gastric ulcer treatment [173][174][175], hypolipidemic properties [176][177][178], and antioxidant activity [179][180][181]. Piperine can also act as an antidepressant by upregulating levels of 5-hydroxyamine or dopamine in the central nervous system [182][183][184], and has demonstrated analgesic [185][186][187] and anti-tumor effects [188][189][190][191]. Moreover, piperine has demonstrated broadspectrum bactericidal activity with no drug resistance [192][193][194][195], and has demonstrated potential as a hypnosis and anticonvulsant agent [196][197][198].…”

Section: Piperinementioning

confidence: 99%

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Qiu,

Zhang,

et al. 2023

J Nanobiotechnol

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Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability, and potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations. This review summarizes the recent advances in nanocarrier-based delivery systems for various types of active constituents of TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, and quinones, from different natural sources. This review covers the design and preparation of nanocarriers, their characterization, and in vitro/vivo evaluations. Additionally, this review highlights the challenges and opportunities in the field and suggests future directions for research. Nanocarrier-based delivery systems have shown great potential in improving the therapeutic efficacy of TCMs, and this review may serve as a comprehensive resource to researchers in this field. Graphical abstract

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“…Piperine is the major compound in the Piperacaeae plant, belonging to the group of alkaloid secondary metabolites [ 20 ]. Some research showed that piperine has many pharmacological effects such as anti-inflammatory, anti-osteoarthritis, anti-rheumatoid arthritis, and anti-cancer [ [21] , [22] , [23] , [24] ]. On the other hand, piperine has very low solubility in water, only about 40 mg/L [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Piperine-hydroxybenzoate as phytochemistry antiosteoarthritis combination: Structural, solubility, and in vivo antiinflammatory study

Sartinah,

Uekusa,

Abekura

et al. 2024

Heliyon

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Evaluation of analgesic, anti-inflammatory, and antipyretic activity of piperine: An experimental study

Cited by 10 publications

References 11 publications

Antinociceptive Properties of Leaf Aqueous Extract of Crossopteryx Febrifuga (Afzel. Ex G. Don) Benth

Antinociceptive Properties of Leaf Aqueous Extract of Crossopteryx Febrifuga (Afzel. Ex G. Don) Benth

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Piperine-hydroxybenzoate as phytochemistry antiosteoarthritis combination: Structural, solubility, and in vivo antiinflammatory study

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