Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of <i>Cordia sebestena</i> L.

Sunaryo, Hadi; Siska, Siska; Hanani, Endang; Anindita, Rs.; Yanti, Ni Komang Wijiani; Lisá,

doi:10.2478/afpuc-2019-0018

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Filtration was used to separate the plant material. A vacuum evaporator was used to concentrate the 70% ethanol extracts at lower pressure (12). The yield of the ethanol extract was 23.34 % w/w.…”

Section: Preparation Of Ethanol Extractmentioning

confidence: 99%

Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats

Siska,

Hanani,

Bariroh

et al. 2023

J Herbmed Pharmacol

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Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti-inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes; However, no scientific evaluation of its antihypertensive activity has been conducted. The purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE) on male rats’ blood pressure, urine volume, and sodium and potassium levels. Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension. A non-invasive tail method was used to measure blood pressure. The sodium and potassium concentrations as well as the total volume of urine were measured from the collected urine. Results: Hypertensive rats’ blood pressure was reduced by 250, 500, and 1000 mg/kg of PBE. Similar to the positive control group (captopril dose of 1.25 mg/kg BW), the most significant drop in blood pressure was occurred at the dose of 1000 mg/kg BW (P>0.05). All treatment groups saw an increase in urinary sodium and potassium levels. Conclusion: In NaCl-induced hypertensive rats, oral administration of P. bleo ethanolic extract decreased blood pressure to the standard value by increasing urinary sodium and potassium levels. Hence, it might be used as an anti-hypertensive agent.

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Section: Preparation Of Ethanol Extractmentioning

confidence: 99%

Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats

Siska,

Hanani,

Bariroh

et al. 2023

J Herbmed Pharmacol

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“…2 C. sebestena has pharmacological activity, such as hepatoprotective, 3 hypoglycaemic, hypolipidemic, antioxidant, 4 antidiabetic, antibacterial, 2 anti-inflammatory, and analgesic. 5,6 The antioxidant is a molecule that significantly inhibits the oxidation of the other substance, although it presents in low concentration. Antioxidants are responsible for defence mechanisms to protect the body from damage to oxidation reactions.…”

Section: Introductionmentioning

confidence: 99%

Total Phenolic Content and Antioxidant Activity of Different Extracts of Cordia sebestena L. Leaves

Lusiana¹,

Hanani²,

Sapitri³

et al. 2020

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Background: Cordia sebestena L. (Boraginaceae) wildly planted in Jakarta, Indonesia. The secondary metabolites of plants have biological and pharmacological activities, such as antioxidant. The antioxidant activity of plants might be due to their phenolic compounds. Objective: To determine the total phenolic content and evaluate the antioxidant activity of C. sebestena leaves extracts (n-hexane, dichloromethane, ethyl acetate, and 70% ethanol). Materials and Methods: The total phenolic content was determined using spectrophotometric methods with a Folin-Ciocalteu reagent. The antioxidant activity of the extracts was determined by its ability to inhibit DPPH radicals through IC 50 values (ppm). Results: The highest total phenolic content (167.61 ± 0.56 mg GAE/g) and best antioxidant activity (31.41 ppm) were found in 70% ethanol extract of C. sebestena compared to other extracts (ethyl acetate > dichloromethane > n-hexane). Conclusion: The C. sebestena leaves have a good potential as a source of natural antioxidant, and further research, is recommended to evaluate the antioxidant activity using another method.

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“…2 Daun Cordia juga mengandung senyawa volatil sebesar 0,05%. 3 Daun cordia memiliki beragam aktivitas farmakologi, antara lain antibakteri, 4 analgetik, antiinflamasi, 5 antioksidan, 6 dan lain sebagainya. Studi mengenai toksisitas subakut dari ekstrak etil asetat daun Cordia menunjukan bahwa ekstrak tersebut tidak toksik terhadap hati.…”

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Analisis Flavonoid pada Fraksi Hasil Hidrolisat Ekstrak Daun Cordia sebestena L.

Hikmawanti,

Hanani,

Mardiyanti

2024

IJPST

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Cordia sebestena L. (Boraginaceae) atau Cordia merupakan tanaman hias dengan kandungan flavonoid. Penelitian ini bertujuan menganalisis senyawa flavonoid pada fraksi hasil hidrolisat ekstrak etanol 70% daun Cordia. Penelitian terbagi menjadi 7 tahapan, yaitu (1) maserasi daun menggunakan etanol 70%, (2) hidrolisis asam pada ekstrak dengan HCl 2N pada 95 °C selama 2 jam, (3) fraksinasi hidrolisat dengan etil asetat, (4) penentuan kadar flavonoid total dengan kolorimetri, (5) pengujian aktivitas antiradikal terhadap 2,2’-difenil-1-pikrilhidrazil (DPPH), (6) pemisahan flavonoid menggunakan kromatografi lapis tipis (KLT), dan (7) identifikasi flavonoid menggunakan spektrofotometri UV-Vis dan infra merah. Hasil menunjukan kadar flavonoid total fraksi etil asetat sebesar 8,20 mgQE/g dengan nilai IC50 terhadap radikal DPPH sebesar 296,91 µg/mL. Kromatogram KLT menunjukkan keberadaan satu bercak senyawa pada fraksi etil asetat dengan nilai hRf adalah 85,5. Hasil spektrum UV-Vis pada bercak tersebut diperoleh serapan pada 340 nm (pita I) dan 240 nm (pita II). Sedangkan spektrum infra merah menunjukan adanya sinyal pada 3363 cm-1 (O-H ulur), 1727 cm-1 (C=O), 1459 cm-1 (cincin aromatik) dan 1060 cm-1 kuat (C-O). Dengan demikian, dapat disimpulkan bahwa fraksi etil asetat hidrolisat ekstrak etanol daun Cordia mengandung senyawa flavonoid yang mirip dengan kelompok kalkon.

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Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

Cited by 4 publications

References 9 publications

Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats

Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats

Total Phenolic Content and Antioxidant Activity of Different Extracts of Cordia sebestena L. Leaves

Analisis Flavonoid pada Fraksi Hasil Hidrolisat Ekstrak Daun Cordia sebestena L.

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