Evaluation of an outpatient department (OPD)-based prescribing pattern of fixed-dose combinations in a tertiary care institute in Central India

Chandel, Satish; Rai, Nitesh; Balakrishnan, Sadashivam; Jhaj, Ratinder; Vishwe, Akash; Gour, Pushpraj; Chenchula, Santenna; Sharma, Shweta

doi:10.1515/jbcpp-2019-0037

Cited by 5 publications

(9 citation statements)

References 12 publications

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“…Analgesic combinations are appropriate for pain management and have been recommended by the WHO, especially for the management of pain of moderate to severe intensity [ 30 ]. In this study, it was found that fewer than one-tenth of patients had dispensing of these pharmaceutical forms, which is consistent with that reported in Japan and India (6.7–13.9%) [ 31 , 32 ]. However, it is important to note that these medications can be used incorrectly and can be dangerous in overdose [ 29 ].…”

Section: Discussionsupporting

confidence: 91%

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Valladales‐Restrepo

Rubio-Londoño

Poveda-Martinez

et al. 2022

Drugs - Real World Outcomes

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Background Analgesics provide multiple clinical benefits but they are not without risks. Objective The aim of this study was to compare the outpatient prescribing pattern of analgesics between cities and municipalities in Colombia and to identify the variables associated with prescribing opioid analgesics. Methods This was a cross-sectional study that identified the prescription of analgesics for outpatient use from a population database of 8.5 million Colombians. A descriptive, bivariate, and multivariate analysis was performed. Results A total of 573,248 patients were identified who had received prescriptions for an analgesic. Mean age was 46.5 ± 23.6 years and 65.7% were females. The most commonly prescribed analgesics were non-opioid analgesics, antispasmodics, and opioid analgesics. The average milligram equivalent of morphine was higher in capital cities than in municipalities. Age ≥ 65 years (odds ratio [OR] 2.60, 95% confidence interval [CI] 2.54-2.67), male sex (OR 1.09, 95% CI 1.07-1.11), dispensing in cities (OR 2.25, 95% CI 2.20-2.30) and experiencing chronic pain (OR 13.25, were associated with an increased risk of receiving an opioid analgesic. Conclusions Differences were found in the prescription of analgesics between capital cities and municipalities. The use of opioids does not appear to be in line with the recommendations for clinical practice, and they were mainly prescribed for elderly males with chronic non-oncological pain and for residents of capital cities.

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Section: Discussionsupporting

confidence: 91%

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Valladales‐Restrepo

Rubio-Londoño

Poveda-Martinez

et al. 2022

Drugs - Real World Outcomes

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“…The overall percentage of prescriptions with FDC was slightly higher when compared to another study from central India (43% in the present study vs 38% reported in that study). 7 Overall, multivitamins and minerals constituted the most commonly used FDC category in this study, as against the results…”

Section: Discussionmentioning

confidence: 51%

“…Although there are a few studies from India which describe FDC usage patterns (especially concerning irrational FDCs), a majority of these were carried out either at a single center or at most by involving a few centers. [6][7][8] In order to fill this gap, we present the findings from prescription evaluation research regarding FDC usage conducted in 13 tertiary care hospitals across India. The main purpose was not only to analyze the pattern of commonly used FDCs but also to see whether the prescriptions included (1) any of the FDCs that were banned at some point in time or (2) any of the FDCs that were classified as irrational (by CDSCO).…”

Section: Primary Data Collectionmentioning

confidence: 99%

“…The potential harm due to the use of such irrational FDCs is difficult to measure and reported earlier. 7 This is to be expected considering the widely prevalent usage of multivitamins and minerals, and the tendency to combine these preparations for human consumption. From a rational use perspective, however, it is rare to have multiple deficiencies of vitamins and minerals concurrently.…”

Section: Five Commonly Used Fdcs In Each Centermentioning

confidence: 99%

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Usage Pattern of Fixed-dose Combinations at ICMR Network of Rational Use of Medicine Centres across India: Recommendations for Policymakers and Prescribers

Ranjalkar¹,

Jhaj²,

Chandy³

et al. 2023

JAPI

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Aim: Irrational use of medicines is a global problem. In India, one contributing factor is the availability of a large number of fixed-dose combinations (FDCs). To improve rational use and to strengthen policies, it is important to assess the usage patterns and rationality of FDCs. Methods: This study was conducted as part of a 1-year prospective cross-sectional analysis of prescriptions in the outpatient clinics of broad specialities from 13 tertiary care hospitals across India. Five most commonly prescribed FDCs in each center were analyzed. In addition, all the prescribed FDCs were classified as per the Kokate Committee classification and it was noted whether any of the FDCs were irrational or banned as per the reference lists released by regulatory authorities. Results: A total of 4,838 prescriptions were analyzed. Of these, 2,093 (43.3%) prescriptions had at least one FDC. These 2,093 prescriptions had 366 different FDCs. Of the 366 FDCs, 241 were rational; 10 were irrational; 14 required further data generation; and the remaining 96 FDCs could not be categorized into any of the above. Vitamins and minerals/supplements, antibacterial for systemic use, and drugs for gastroesophageal reflux disease (GERD) and peptic ulcer were the most used FDCs. Conclusion: Based on the finding that some prescriptions contained irrational FDCs, it is recommended that a rigorous, regular, and uniform method of evaluation be implemented to approve/ban FDCs and that prescribers be periodically notified about the status of the bans.

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“…Hence, awareness of physicians in prescribing rational FDCs was the need of the hour. [27,28] In the current study, all prescriptions contained the dosage form, dose frequency, and treatment duration. The limitation of this study was that it did not encompass the adverse effect of the drugs prescribed.…”

Section: Who Prescribing Indicators Total Drugs/ Encountersmentioning

confidence: 99%

Assessment of Prescription Pattern of Drugs Prescribed in the Outpatient Department of a Private Orthopedic Hospital – A Cross-sectional Study

Gujar

Gulecha

Zalte

2021

APJHS

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Background: Drug utilization research (DUR) is vital in the health sector as it offers insight into the efficacy of drug use. The findings of DUR studies can help set goals for the rational use of drugs and health-care funds distribution. Objective: The objective of this DUR study was to evaluate the prescription pattern of drugs prescribed in the outpatient department (OPD) of a private orthopedic hospital. Settings and Design: The study was a cross-sectional, prospective, and observational study conducted at the OPD of a private orthopedic hospital. Materials and Methods: The study was carried out over a 6-month duration (from October 2020 to March 2021) at the OPD of a private orthopedic hospital and studied 609 prescriptions using the World Health Organization (WHO) recommended prescribing indicators. Statistical Analysis Used: Microsoft Excel and SPSS version 26.0 were used to capture and analyze the data of the study. Results: A total of 3082 drugs were prescribed in 609 prescriptions. The average number of drugs prescribed per encounter was 5.1 (SD = 1.9). Drugs prescribed using generic name of the drug were 2.6%, the encounters with an antibiotic and an injection prescribed were 39.4% and 7.1%, respectively. The drugs prescribed from the essential drugs list were 38.9%. In addition, vitamins and supplements (32.1%) were prescribed the most followed by analgesics (24.2%) and antacids (16.6%). Conclusions: The study highlighted the inadequate compliance with the WHO recommended prescribing indicators and suggested a need to train physicians and spread awareness about writing rational prescriptions, benefitting the patient.

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Evaluation of an outpatient department (OPD)-based prescribing pattern of fixed-dose combinations in a tertiary care institute in Central India

Cited by 5 publications

References 12 publications

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Prescribing Pattern of Analgesics in Colombia. Are there Differences between Capital Cities and Municipalities? A Cross-Sectional Study

Usage Pattern of Fixed-dose Combinations at ICMR Network of Rational Use of Medicine Centres across India: Recommendations for Policymakers and Prescribers

Assessment of Prescription Pattern of Drugs Prescribed in the Outpatient Department of a Private Orthopedic Hospital – A Cross-sectional Study

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