Evaluation of an in vivo prompt gamma neutron activation facility for body composition studies in critically ill intensive care patients: Results on 41 normals

Beddoe, A H; Streat, Stephen; Hill, Graham L.

doi:10.1016/0026-0495(84)90050-7

Cited by 74 publications

(38 citation statements)

References 23 publications

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“…Body composition measurements will include gold-standard methods: dual-energy x-ray absorptiometry (DEXA) to determine fat mass [56, 57], total body potassium to assess body cell mass [58], in vivo neutron activation analysis for body nitrogen to determine total body protein [59], and deuterium dilution to determine total body water [60]. In addition, bioelectrical impedance assessment will be carried out as a surrogate measurement of total body water, extracellular water and fat mass [61].…”

Section: Methodsmentioning

confidence: 99%

The effect of intensive nutrition interventions on weight gain after kidney transplantation: protocol of a randomised controlled trial

et al. 2014

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BackgroundWeight gain and obesity are common after kidney transplantation, particularly during the first year. Obesity is a risk factor for the development of new-onset diabetes after transplantation, and is associated with reduced graft survival. There is a lack of evidence for effective interventions to prevent weight gain after kidney transplantation.Methods/DesignThe effect of INTEnsive Nutrition interventions on weight gain after kidney Transplantation (INTENT) trial is a single-blind (outcomes assessor), randomised controlled trial to assess the effect of intensive nutrition interventions, including exercise advice, on weight gain and metabolic parameters in the first year after transplantation. Participants will be randomised during the first post-transplant month to either standard care (four visits with a renal dietitian over twelve months) or intensive nutrition intervention (eight visits with a renal dietitian over the first six months, four visits over the second six months, and three visits over the first six months with an exercise physiologist). In the intensive intervention group, nutrition counselling will be provided using motivational interviewing techniques to encourage quality engagement. Collaborative goal setting will be used to develop personalised nutrition care plans. Individualised advice regarding physical activity will be provided by an exercise physiologist. The primary outcome of the study is weight at six months after transplant, adjusted for baseline (one month post-transplant) weight, obesity and gender. Secondary outcomes will include changes in weight and other anthropometric measures over 12 months, body composition (in vivo neutron activation analysis, total body potassium, dual-energy X-ray absorptiometry, and bioelectrical impedance), biochemistry (fasting glucose, lipids, haemoglobin A1c and insulin), dietary intake and nutritional status, quality of life, and physical function.DiscussionThere are currently few randomised clinical trials of nutrition interventions after kidney transplantation. The INTENT trial will thus provide important data on the effect of intensive nutrition interventions on weight gain after transplant and the associated metabolic consequences. Additionally, by assessing changes in glucose metabolism, the study will also provide data on the feasibility of undertaking larger multi-centre trials of nutrition interventions to reduce the incidence or severity of diabetes after transplantation.Trial registrationAustralian New Zealand Clinical Trials Registry Number: ACTRN12614000155695

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Section: Methodsmentioning

confidence: 99%

The effect of intensive nutrition interventions on weight gain after kidney transplantation: protocol of a randomised controlled trial

et al. 2014

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“…The ®rst component in this model, total body water, is quanti®ed using either tritiated water or deuterium dilution. Total body nitrogen is next measured with the technique referred to as prompt gamma neutron activation analysis (Beddoe et al, 1984;Dutton, 1991;Kyere et al, 1982;Mernagh et al, 1977;Pierson et al, 1990;Varstsky et al, 1984). Total body nitrogen is then used to calculate total body protein mass.…”

Section: Molecular Levelmentioning

confidence: 99%

Multi-component body composition models: recent advances and future directions

Pietrobelli

Heymsfield

et al. 2001

Eur J Clin Nutr

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Objective: This overview examines concepts related to a category of body composition methods generally referred to as multi-component models, that is, those models that include three or more components. We summarize the rationale for, applications, and types of multi-component models along with sources of error. Our review presents the strengths and limitations of available models and identi®es important future research directions.

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“…The only really satisfactory technique is neutron activation analysis, but that involves signi®cant amounts of radiation and is not widely available. In New Zealand a facility has been built for use in critically ill patients (Beddoe et al, 1984).…”

Section: Body Mass and Composition In Mofmentioning

confidence: 99%

Limitations of nutrient intake. The effect of stressors: trauma, sepsis and multiple organ failure

1999

Eur J Clin Nutr

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Evaluation of an in vivo prompt gamma neutron activation facility for body composition studies in critically ill intensive care patients: Results on 41 normals

Cited by 74 publications

References 23 publications

The effect of intensive nutrition interventions on weight gain after kidney transplantation: protocol of a randomised controlled trial

The effect of intensive nutrition interventions on weight gain after kidney transplantation: protocol of a randomised controlled trial

Multi-component body composition models: recent advances and future directions

Limitations of nutrient intake. The effect of stressors: trauma, sepsis and multiple organ failure

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