Evaluation of an HIV recent infection testing algorithm with serological assays among men who have sex with men in Mexico

Karatzas-Delgado, Eli F.; Ruiz-González, Verónica; García-Cisneros, Santa; Olamendi-Portugal, María; Herrera-Ortíz, Antonia; López‐Gatell, Hugo; González-Rodríguez, Andrea; Sánchez-Alemán, Miguel Ángel

doi:10.1016/j.jiph.2019.11.002

Cited by 12 publications

(17 citation statements)

References 14 publications

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“…A previous study showed that FRR was reduced from 4.9% to 0.4% when VL was incorporated into an algorithm initially consisting of the recency assay and CD4+ T cell count. (Karatzas-Delgado et al, 2020) This study conducted in Mexico also showed that the FRR could be largely reduced when combined with clinical information. (Karatzas-Delgado et al, 2020) This study showed that using the recency assay only, using the recency assay with CD4+ T cell count, using the recency assay with VL, and using the recency assay with both CD4+ T cell count and VL had different FRR of 5.4%, 4.9%, 0.4%, and 0%, respectively.…”

Section: Discussionmentioning

confidence: 76%

“…(Karatzas-Delgado et al, 2020) This study conducted in Mexico also showed that the FRR could be largely reduced when combined with clinical information. (Karatzas-Delgado et al, 2020) This study showed that using the recency assay only, using the recency assay with CD4+ T cell count, using the recency assay with VL, and using the recency assay with both CD4+ T cell count and VL had different FRR of 5.4%, 4.9%, 0.4%, and 0%, respectively. Therefore, among the four RITAs in our analysis, RITA 4, which combines the LAg-Avidity EIA assay with CD4+ T cell count and VL, will be the most accurate in classifying recent HIV infection cases.…”

Section: Discussionmentioning

confidence: 76%

“…It has been observed that FRR of the HIV recency assay is high in virally-suppressed patients, such as ART-treated patients who have suppressed viral replication or viral controllers who can spontaneously control viral replication and maintain high CD4+ T cell counts; this could be due to the impact of antiretroviral drugs or lack of viral exposure to induce production of antibodies with high avidity (Kassanjee et al, 2014). Therefore, the exclusion criteria of VL <1000 copies/mL is commonly used to exclude virally suppressed HIV cases and reduce FRR (Karatzas-Delgado et al, 2020). It is noteworthy that a small portion of HIV cases has clinical testing results of CD4+ T cells <200 cells/ml and VL <1000 copies/mL.…”

Section: Discussionmentioning

confidence: 99%

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Identifying major drivers of incident HIV infection using recent infection testing algorithms (RITAs) to precisely inform targeted prevention

Zhu¹,

Wang

Liu

et al. 2020

International Journal of Infectious Diseases

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Background: Recent infection testing algorithms (RITAs) incorporating clinical information with the HIV recency assay have been proven to accurately classify recent infection. However, little evidence exists on whether RITAs would help in precisely identifying major drivers of the ongoing HIV epidemic. Methods: HIV recency test results and clinical information were collected from 1152 newly diagnosed HIV cases between 2015 and 2017 in Dehong prefecture of Yunnan province, and the efficacy of four different RITAs in identifying risk factors for new HIV infection was compared. Results: RITA 1 uses the recency test only. RITA 2 and RITA 3 combine the recency test with CD4+ T cell count and viral load (VL), respectively. RITA 4 combines both CD4+ T cell count and VL. All RITAs identified the MSM group and young people between 15 and 24 years as risk factors for incident HIV infection. RITA 3 and RITA 4 further identified the Dai ethnic minority as a risk factor, which had not been identified before when only the HIV recency test was used. Conclusions: By comparing different RITAs, we determined that greater accuracy in classifying recent HIV infection could help elucidate major drivers impacting the ongoing epidemic and thus inform targeted interventions.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying major drivers of incident HIV infection using recent infection testing algorithms (RITAs) to precisely inform targeted prevention

Zhu¹,

Wang

Liu

et al. 2020

International Journal of Infectious Diseases

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“…The current study shows the HIV incidence from MSM at the national and regional levels, and this data was not collected only from local surveys or by only including the general population. For this work, we considered the use of the RITA algorithm and a specific FRR for correction, as recommended by the World Health Organization [ 5 , 12 ]. A publication by Hallett T. in 2011 showed that none of 39 studies analysed corrected the results or data obtained from other populations or regions by a specific FRR; consequently, the incidence estimations may contain errors [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…To classify recent infections, we first generated an algorithm that included the HIV Ag/Ab Combo assay, information about antiretroviral therapy (ART), and BED EIA HIV-1 test results. To estimate the incidence, we used recent HIV infections and the formula proposed by Hargrove et al with a 1.3% correction factor (FRR) previously obtained for MSM from Mexico City for DBS samples and the BED EIA HIV-1 test [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

Regional disparity of HIV incidence and prevalence among men who have sex with men

et al. 2021

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Background HIV incidence can be estimated with cross-sectional studies using clinical, serological, and molecular data. Worldwide, HIV incidence data in only men who have sex with men (MSM) are scarce and principally focus on those with healthcare or under treatment. However, better estimates can be obtained through studies with national representativeness. The objective was to estimate the prevalence, incidence, and factors associated with acquiring HIV in a national sample of MSM who attend meeting places, considering geographical regions. Methods A nationally representative survey of MSM attending meeting places was performed in Mexico. Participants answered a questionnaire, and a dried blood spot (DBS) was collected. Samples were classified as recent infections using an algorithm with HIV status, antiretroviral therapy, and the result of BED-EIA assay. Parameters were analysed considering regions and demographic and sexual behaviour characteristics. Results The national HIV prevalence was 17.4% with regional differences; the highest prevalence (20.7%) was found in Mexico City, and the lowest prevalence was found in the West region (11.5%). The incidence was 9.4 per 100 p/y, with regional values from 6.2 to 13.2 for the Northeast and the Centre regions, respectively. Age, age at sexual debut, low wealth index, and rewarded sex were associated with HIV prevalence. Centre region, use of private clinics as health services, and having sex exclusively with men were associated with recent HIV infections. Conclusions The incidence and prevalence showed regional differences, suggesting a difference in the dynamics of HIV transmission; some regions have a greater case accumulation, and others have a greater rate of new infections. Understanding this dynamic will allow developing health programs focused on HIV prevention or treating people already living with HIV.

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Development of a multiassay algorithm (MAA) to identify recent HIV infection in newly diagnosed individuals in Indonesia

Wulan,

Yunihastuti,

Arlinda

et al. 2023

iScience

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Evaluation of an HIV recent infection testing algorithm with serological assays among men who have sex with men in Mexico

Cited by 12 publications

References 14 publications

Identifying major drivers of incident HIV infection using recent infection testing algorithms (RITAs) to precisely inform targeted prevention

Identifying major drivers of incident HIV infection using recent infection testing algorithms (RITAs) to precisely inform targeted prevention

Regional disparity of HIV incidence and prevalence among men who have sex with men

Development of a multiassay algorithm (MAA) to identify recent HIV infection in newly diagnosed individuals in Indonesia

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