Evaluation of an Experimental Vaccine for Atrophic Rhinitis in Piglets

Gu, Shijiang; Fan, Yangyang; Hu, Dongbo; Li, Xiangdong

doi:10.4172/2157-7560.1000353

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many types of vaccines against AR have been developed with various combinations of whole cell bacterins and inactivated or recombinant forms of PMT (Liao et al, 2006;Kang et al, 2008;Hsuan et al, 2009;Gu et al, 2017). Among them, vaccine containing antigens from both pathogens is regarded as most effective based on the following facts; (1) Monovalent PMT vaccine showed inferior efficacy compared to RESEARCH ARTICLE bivalent B. bronchiseptica and P. multocida vaccine at challenge experiment.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Economic Impacts of a Commercial Vaccine Containing Recombinant Antigen against Atrophic Rhinitis in Field Conditions

Kim¹

2018

PVJ

View full text Add to dashboard Cite

Atrophic rhinitis (AR) is an important disease continuously causing economic losses to pig industry. Due to the detrimental effects on growth performance, antibiotics have been widely used to treat the bacterial diseases in the field. As the concerns about bacterial resistance to antibiotics increase, there is a growing need for the evaluation of AR vaccine that can reflect actual cost and benefits. However, until now, only limited research data have been available. Therefore, in this study, the systemic analyses of clinical and economic benefits by AR vaccination under field conditions were conducted. The trials were performed using a bivalent commercial vaccine containing Bordetella bronchiseptica bacterin and recombinant Type D Pasteurella multocida toxin in three different commercial pig farms endemic for AR. Significant higher levels of colostral antibodies and those passive transfer were detected from vaccinated sows to their offspring compared to non-vaccinated groups. As predicted on serological data, notably better clinical protection from the deleterious effects of AR was identified in piglets born to the vaccinated sows based on body weight, rearing period, and gross nasal scores. Moreover, vaccination on sows delivered a return on investment at least ten times the cost of vaccination. Collectively, these favorable clinical and economic effects in the commercial farms sufficiently support the necessity and significance of AR vaccination on sows.

show abstract

Section: Introductionmentioning

confidence: 99%