Evaluation of an automated fluorescence polarization immunoassay for vancomycin

Filburn, B H; Shull, V H; Tempera, Y M; Dick, James D.

doi:10.1128/aac.24.2.216

Cited by 40 publications

(18 citation statements)

References 5 publications

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“…The serum was stored at -20 °C and was analyzed by fluorescence polarization immunoassay (TDX, Abbott Diagnostics, Irving, Tex.) within 24 h [11], The coefficient of variation of this assay was < 7 %. The serum creatinine was also determined on the study day.…”

Section: Introductionmentioning

confidence: 96%

Vancomycin Pharmacokinetics in Infants: Relationship to Postconceptional Age and Serum Creatinine

Kildoo¹,

Lin²,

Gabriel³

et al. 1990

Dev Pharmacol Ther

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Multidose pharmacokinetics of vancomycin were studied in 15 infants with gestational age <36 weeks and suspected or confirmed Staphylococcus epidermidis infections. Postconceptional age (PCA) at the time of the study ranged from 26 to 44 weeks. Vancomycin individual doses ranged from 6.7 to 10.6 mg/kg and were infused over 60 min. Five postinfusion samples were obtained in 13 infants, while 4 samples were obtained in 2 patients. Vancomycin pharmacokinetic parameters were determined by fitting the data to a two-compartment model using a weighted least-squares nonlinear regression method. Mean vancomycin body clearance (CL), volume of distribution (V(dss)) and terminal elimination half-life were 1.37 ml/min, 0.58 liters and 5.6 h, respectively. When standardized for patient weight, the CL and V(dss) values were 1.07 ml/min/kg and 0.48 liters/kg, respectively. The CL (ml/min/kg) was strongly inversely correlated with the serum creatinine (r = -0.82), while a weaker but significant association was noted with PCA (r = 0.41). These data suggest that in sick infants, in addition to the PCA, serum creatinine should be considered when determining the initial vancomycin dosing regimen.

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Section: Introductionmentioning

confidence: 96%

Vancomycin Pharmacokinetics in Infants: Relationship to Postconceptional Age and Serum Creatinine

Kildoo¹,

Lin²,

Gabriel³

et al. 1990

Dev Pharmacol Ther

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“…2.5, 4.5, 6.5, 8.5 and 10 h after the start of drug administration and the serum was separated. All the dialysate was cooled on ice and collected every 2 h. Vancomycin was determined by fluorescence polarization immunoassay [10].…”

Section: Methodsmentioning

confidence: 99%

Effects of Slowly Performed Daytime Hemodialysis (Slow HD) on the Pharmacokinetics of Vancomycin in Hemodynamically Unstable Patients with Renal Failure

et al. 1996

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Effects of slowly performed daytime hemodialysis (slow HD) using a high-flux hemodialyzer on the pharmacokinetics of vancomycin were determined in 5 critically ill patients with renal failure. Following intravenous administration of 0.5 g of vancomycin, concentrations in the serum and dialysate were monitored. Pharmacokinetic parameters were calculated after fitting individual concentration-time curves to a two-compartment model. The volume of distribution at steady state was 0.58 ± 0.12 liters/kg. Total body clearance was 37.46 ± 3.20 ml/min with an elimination phase half-life of 8.72 ± 0.99 h. Slow HD clearance was 20.19 ± 2.30 ml/min. During a 10-hour session of slow HD, the serum vancomycin concentration decreased from 44.2 ± 3.8 to 10.0 ± 5.0mg/l and 30.10 ± 5.34% of the dose was eliminated. Dialyzer clearance of this drug and urea was 18.71 ± 1.40 and 28.77 ± 1.77 ml/min, respectively. Slow HD may effectively eliminate vancomycin by a diffusive mechanism and this elimination should be taken into consideration for designing the dosage schedule during the treatment.

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“…On day 2 or day 3 after the start of antimicrobial therapy, serum and CSF samples were obtained simultaneously, and vancomycin concentrations were determined using the fluorescent polarization immunoassay [16]. The susceptibility of S. pneumoniae isolates to b-lactam agents and vancomycin was determined for all patients from whom this organism was obtained by culture (12 patients).…”

Section: Methodsmentioning

confidence: 99%

Levels of Vancomycin in Cerebrospinal Fluid of Adult Patients Receiving Adjunctive Corticosteroids to Treat Pneumococcal Meningitis: A Prospective Multicenter Observational Study

Ricard

Wolff

Lachérade

et al. 2007

Clinical Infectious Diseases

120

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Evaluation of an automated fluorescence polarization immunoassay for vancomycin

Cited by 40 publications

References 5 publications

Vancomycin Pharmacokinetics in Infants: Relationship to Postconceptional Age and Serum Creatinine

Vancomycin Pharmacokinetics in Infants: Relationship to Postconceptional Age and Serum Creatinine

Effects of Slowly Performed Daytime Hemodialysis (Slow HD) on the Pharmacokinetics of Vancomycin in Hemodynamically Unstable Patients with Renal Failure

Levels of Vancomycin in Cerebrospinal Fluid of Adult Patients Receiving Adjunctive Corticosteroids to Treat Pneumococcal Meningitis: A Prospective Multicenter Observational Study

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