Evaluation of Amphetamine-Related Hospitalizations and Associated Clinical Outcomes and Costs in the United States

Abstract

Key Points Question What are the current trends in frequency and costs of amphetamine-related hospitalizations in the United States? Findings In this cross-sectional study of approximately 1.3 million amphetamine-related US hospitalizations between 2003 and 2015, hospitalizations increased substantially by 2015, with the highest frequency being in the western United States and the predominant payer being Medicaid. Meaning Amphetamine use may be an emerging public health issue; pharmacologic and nonpharmacologic therapies that effectively treat amphetamine use disorder are needed.

Comparison of Clinical Characteristics and Outcomes of Patients With Reversible Versus Persistent Methamphetamine-Associated Cardiomyopathy

“…The rMAC group's improvement of LVEF and other echocardiographic parameters leads to near normalization of the attendant morbidities and mortalities. As the methamphetamine epidemic 25 continues to exact heavy tolls on diverse communities and strains healthcare delivery systems in the United States, our findings provide clinicians and public health agencies with a powerful mandate to outreach, educate and care for patients with MAC. Intense efforts ought to be targeting the at-risk population to reduce the impact of this preventable, now proven reversible disease.…”

Inpatient Addiction Medicine Consultation and Post-Hospital Substance Use Disorder Treatment Engagement: a Propensity-Matched Analysis

“…Hospitals are increasingly filled with people suffering from medical complications of substance use disorders (SUD) (1,2). One in seven patients in general hospitals have a substance use disorder (3) and hospitalizations for opioid-and methamphetamine-related diagnoses are surging (4)(5)(6). Patients with SUD have longer lengths of stay, higher costs (6), and higher readmission rates (3).…”

The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse

“…Introduction Methamphetamine (METH) use disorder (MUD) has been increasing yearly since at least 2008 and its use as an illicit drug is second only to opioid abuse (Winkelman et al, 2018;Artigiani et al, 2019). Recovery from MUD is difficult, with rates of relapse over 60% within the first year of abstinence (Brecht and Herbeck, 2014).…”