Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients

Abstract

Although the recipient site in burn wounds is dressed with universally accepted materials, the ideal management of split-thickness skin donor sites remains controversial. The aim of our study is to compare two methods of wound dressing in donor sites of split-thickness skin graft in patients undergoing burn wound reconstructive surgery. Forty-two consecutive patients with second-and thirddegree burns with a total body surface area between 20 and 40 % were enrolled in this randomized clinical trial conducted in Motahari Burn Hospital in Tehran, Iran. In each patient, two anatomic areas with similar features were randomly selected as intervention and control donor sites. The intervention site was dressed with amniotic membrane, whereas the control site was treated with Vaselineimpregnated gauze. Wounds were examined daily by expert surgeons to measure the clinical outcomes including duration of healing, severity of pain, and infection rate. The

Successful treatment of painful chronic wounds with amniotic and umbilical cord tissue: A case series

“…39 AM tissue has been shown to improve burn and wound related pain and increase patient tolerance during wound dressing changes. 31,32,40,41 Several prospective, randomized controlled trials have also shown that AM significantly reduces postoperative pain and can even lower analgesic usage as soon as 24 h postop. [42][43][44] AM and UC are also valu able in especially providing biological factors to accelerate the healing process by managing the cellular and molecular environment.…”

Effect of the Use of the Human Amniotic Membrane in Healing of Surgically Induced Skin Defects in Rabbits (Histopathological Study)

“…Because suitable autografts for transplantation are very rarely present and the demand for allograft skin exceeds the supply, not to mention the high cost of tissue engineered skin substitutes, it has been a significant need to use the amniotic membrane as a biological dermal substitute that has low antigenicity, good adherence to the wound surface, potential antimicrobial activity, beside its abundant availability (12).…”

“…As it originates from ectoderm, its features are similar to human skin and hence it is an alternative dressing for skin graft. It provides significant benefits by increasing patients' comfort through decreasing pain sensation, prevent dehydration, trauma, associated infection and improving the process of wound healing with less scar tissue (12).…”

Human Amniotic Membrane Is Not Suitable for the Grafting of Colon Lesions and Prevention of Adhesions in a Xenograft Rat Model

“…cryopreservation method with interesting long-term storage possibilities, 17 HAMs have been broadly applied in a wide range of clinical studies as corneal replacement, skin graft donor-side dressing in burn patients, and graft for oropharyngeal fistula. [17][18][19][20][21] Currently, there is a growing interest in extending the application possibilities of HAMs because of their wide availability, low costs, and biological properties. The aim of our study was to assess the mechanical, inflammatory and allergenic properties of HAMs in a xenograft rat model in the hope that successful xenotransplantation might pave the way for clinical applications according to the IDEAL stages of surgical innovation.…”