Evaluation of ammonium lactate in the treatment of seborrheic keratoses

Klaus, Maria V.; Wehr, Richard F.; Rogers, Roy S.; Russell, Thomas J.; Krochmal, Lincoln

doi:10.1016/0190-9622(90)70023-b

Cited by 15 publications

(6 citation statements)

References 2 publications

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“…There was no significant variance between the study group and the control group's lesions' surface features or color. 49 Tazarotene 0.1% Cream, Calcipotriene 0.05% Ointment, Imiquimod 5% Cream. (NON-RCT)…”

Section: Topicalmentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause postprocedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.

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Section: Topicalmentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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“…42 Hyperkeratotic skin. Hyperkeratotic skin responds to the use of topical keratolytic agents such as ammonium lactate lotion 43 twice daily, and, if pruritic, lowpotency topical steroid creams. 12 Patients commonly develop benign papillomatous growths, presenting as 1-to 3-mm hyperkeratotic warty papules on the skin, which are easily treated with cryotherapy.…”

Section: Resultsmentioning

confidence: 99%

Management of skin adverse reactions in oncology

Silva

Gomes

Lobo

et al. 2020

J Oncol Pharm Pract

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Chemo and targeted anticancer therapies present significant skin adverse reactions, which impair the patients’ quality of life. Cutaneous toxicities lead to poor treatment adherence, drug cessation, and psychosocial distress. This review aims to summarize the current knowledge concerning the prevention and management of skin toxicity arising from these therapies. A systematic literature search on online databases was conducted. The categorization of the main preventive and treatment measures was performed according to the level of evidence. Management of skin adverse reactions of oncology treatments is very heterogeneous, which can be explained by the lack of sound evidence-based treatments. The most studied adverse effects are papulopustular eruption, xerosis, and hand–foot syndrome. Prevention of xerosis stands out as the strategy most supported by level II studies. With respect to treatment, the use of antibiotics in papulopustular eruption resulting from anti-epidermal growth factor receptor agents is the most evidence-based approach. In general, the number of studies published in the literature classified with a level II of evidence (52%) is similar to the ones classified as level IV (33%), making clear the need of more randomized controlled trials regarding the effectiveness of preventive and treatment measures of skin adverse reactions of chemo and targeted anticancer therapies.

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“…Treatment adverse events and recurrence of lesions were not evaluated. 9 Tazarotene 0.1% Cream, Calcipotriene 0.05% Ointment, Imiquimod 5% Cream In this study, topical tazarotene, calcipotriene, and imiquimod were compared with moisturizers and cryosurgery. Once a day application of each medication was compared with twice a day application.…”

Section: Ammonium Lactate 12% Lotionmentioning

confidence: 99%

Topical Treatments for Seborrheic Keratosis: A Systematic Review

Gonzalez¹,

Ramos²,

Ciriaco-Tan³

2020

Acta Med Philipp

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Background. Seborrheic keratosis is a benign skin tumor removed through electrodessication, cryotherapy, or surgery. Alternative options may be beneficial to patients with contraindications to standard treatment, or those who prefer a non-invasive approach. Objectives. To determine the effectiveness and safety of topical medications on seborrheic keratosis in the clearance of lesions, compared to placebo or standard therapy. Methods. Studies involving seborrheic keratosis treated with any topical medication, compared to cryotherapy, electrodessication or placebo were obtained from MEDLINE, HERDIN, and Cochrane electronic databases from 1990 to June 2018. Results. The search strategy yielded sixty articles. Nine publications (two randomized controlled trials, two non randomized controlled trials, three cohort studies, two case reports) covering twelve medications (hydrogen peroxide, tacalcitol, calcipotriol, maxacalcitol, ammonium lactate, tazarotene, imiquimod, trichloroacetic acid, urea, nitric-zinc oxide, potassium dobesilate, 5-fluorouracil) were identified. The analysis showed that hydrogen peroxide 40% presented the highest level of evidence and was significantly more effective in the clearance of lesions compared to placebo. Conclusion. Most of the treatments reviewed resulted in good to excellent lesion clearance, with a few well tolerated minor adverse events. Topical therapy is a viable option; however, the level of evidence is low. Standard invasive therapy remains to be the more acceptable modality.

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Evaluation of ammonium lactate in the treatment of seborrheic keratoses

Cited by 15 publications

References 2 publications

Update of pathophysiology and treatment options of seborrheic keratosis

Update of pathophysiology and treatment options of seborrheic keratosis

Management of skin adverse reactions in oncology

Topical Treatments for Seborrheic Keratosis: A Systematic Review

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